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| 1 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 2 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 3 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 4 | Microchimerism in recurrent miscarriage显示文摘在怀孕期间,在 microchimerism 的获得的结果,它经久地装在两个接受者坚持的母亲胎儿的房间交换。自然地获得的 microchimerism 可以在怀孕影响母亲胎儿的相互作用。我们进行了研究问一个女人从她的自己的母亲获得了的 microchimerism 是否是可检测的在前或在在有周期性的流产的女人的怀孕期间。胎儿的 microchimerism 也是 assayed。有主要自发的周期性的流产的女人(n= 23 ) 并且控制(n= 31 ) 被学习。Genotyping 为 probands,他们的母亲和胎儿,被进行识别的非分享的多型性和量的聚合酶链反应表现了测量 microchimerismin 外设血 mononuclear 房间。预想比较在周期性的流产题目和控制之间被做,用逻辑回归和 Wilcoxon 等级和。在周期性的流产题目的随后的怀孕的纵的 microchimerism 被描述。向在周期性的流产对控制的 microchimerism 的更低的预想察觉有一个趋势, 6 %对 19 %(1/16 对 6/31, P= 0.2 ) 。在怀孕期间, 3/11 (27 %) 继续了有的周期性的流产题目,出生从他们的自己的母亲有 microchimerism 的察觉,而任何一个继续了流产的二个题目都没有察觉(0/2 ) 。这个起始的数据当可检测时,与周期性的流产在女人从一个女人的自己的母亲建议那 microchimerism,可以不同于控制并且根据随后的怀孕结果。进一步的研究被需要在周期性的流产决定房间类型,数量和 microchimerism 的任何潜在的功能的角色。 | Hilary S Gammill Mary D Stephenson Tessa M Aydelotte J Lee Nelson | 2014 | Cellular & Molecular Immunology2014，11，6： | 2 |
| 5 | Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews显示文摘 | Paul K Nelson Bradley M Mathers Benjamin Cowie Holly Hagan Don Des Jarlais Danielle Horyniak Louisa Degenhardt | 2011 | The Lancet . 2011 (9791)2011，，： | 2 |
| 6 | Lead distribution in a simulated aquatic environment:effects of bacterial biofilms and iron oxide显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Water Research1995，29，8： | 2 |
| 7 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 8 | Adsorption of Pb and Cd onto metal oxides and organic material in natural surface coatings as determined by selective extractions:New evidence for the Importance of Mn and Fe Oxides显示文摘 | Dong D Nelson Y M Lion L W | 2000 | Water Research2000，34，2： | 2 |
| 9 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 10 | Microstructural investigation of friction stir welded 7050-T651 aluminium显示文摘 | J.-Q Su T.W Nelson R Mishra M Mahoney | 2002 | Acta Materialia2002，，3： | 2 |
| 11 | Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment显示文摘 | Rowena McBeath Dana M Pirone Celeste M Nelson Kiran Bhadriraju Christopher S Chen | 2004 | Developmental Cell2004，，4： | 2 |
| 12 | Diaspore weight,dispersal,growth form and central Australian plants显示文摘 | Jurado E M Westoby Nelson D | 1991 | J Ecology1991，79，： | 2 |
| 13 | Soil moisture: A central and unifying theme in physical geography显示文摘 | Legates David R Mahmood Rezaul Levia Delphis F DeLiberty Tracy L Quiring Steven M Houser Chris Nelson Frederick E | 2011 | Progress in Physical Geography2011，，1： | 2 |
| 14 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 15 | Microstructural investigation of friction stir welded 7050-T651 aluminium显示文摘 | J.-Q Su T.W Nelson R Mishra M Mahoney | 2002 | Acta Materialia2002，，3： | 2 |
| 16 | On CMP of silicon nitride (Si3N4) work material with various abrasives显示文摘 | Jiang M Nelson O | 1998 | Wear1998，22，1： | 2 |
| 17 | Janus kinases and their role in growth and disease显示文摘 | Aringer M Cheng A Nelson JW | 1999 | Life Sci1999，64，24： | 1 |
| 18 | Techniques for the isolation, culture and preservation of the Fusaria显示文摘 | Tio M Burgess L W Nelson P E | 1977 | Australian Plant Pathology Society Newsletter1977，6，： | 1 |
| 19 | The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog 显示文摘 | Putnam R A Nelson J O Clark J M | 2003 | Agric Food Chem2003，51，： | 1 |
| 20 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
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