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| 1 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 2 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 3 | Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bagchi Sidney J Stohs Dipak K Das Sidhartha D Ray Charles A Kuszynski Shantaram S Joshi Harry G Pruess | 2000 | Toxicology2000，，2： | 3 |
| 4 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 5 | An observer-based compensator for distributed delays显示文摘 | Luck R Ray A | | 0，，： | 2 |
| 6 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 7 | Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract显示文摘 | Debasis Bagchi Chandan K Sen Sidhartha D Ray Dipak K Das Manashi Bagchi Harry G Preuss Joe A Vinson | 2003 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2003，，： | 2 |
| 8 | Long-range atmospheric transport of soil dust from Asia to the Tropical North Pacific: Temporal variability显示文摘 | Duce R A Unni C K Ray B J | 1980 | Science1980，209，26： | 2 |
| 9 | Integrated communication and control systems:Part Ⅰ --Analysis显示文摘 | Halevi Y Ray A | 1988 | ASME J of Dynamic Systems Measurement and Control1988，110，4： | 1 |
| 10 | Experimental verification of a delay compensation algorithm for integrated communication and control systems 显示文摘 | LUCK R RAY A | 1994 | International Journal of Control1994，59，： | 1 |
| 11 | Bressan 2005 Abiotic Stress and Plant Genome Evolution显示文摘 | HANS J BOHNERT RAY A | 2005 | Search for New Models Plant Physiology2005，138，5： | 1 |
| 12 | Phytase-producing bacteria in the digestive tracts of some freshwater fish显示文摘 | Roy T Mondal S Ray A K | 2009 | Aquaculture Research2009，40，： | 1 |
| 13 | Multiobjective optimiza-tion of SMB and Varicol process for chiral separation显示文摘 | Zhang Z Y Hidajat K Ray A K | 2002 | AIChE Journal2002，48，12： | 1 |
| 14 | Phenolic constituents of Rhus semialata leaves显示文摘 | Bagchi A Sahai M Ray AB | 1985 | Planta Medica1985，5，： | 1 |
| 15 | Using antisense RNA to study gene function: inhibition of carotenoid biosynthesis in transgenic tomatoes显示文摘 | Bird C R Ray J A Fletcher J D | 1991 | Biotechnology1991，9，： | 1 |
| 16 | Sin 1,amutation affecting female fertility in Arabidopsis,interacts with modl,its recessive modifier显示文摘 | LANG J D RAY S RAY A | 1994 | Genetics1994，137，4： | 1 |
| 17 | Integrated communication and control systems:part Ⅰ analysis显示文摘 | Halevi Y Ray A | 2003 | ASME Journal of Dynamic Sytems Measurement and Control2003，110，4： | 1 |
| 18 | Improvement of quality of sesame (Seasamum indicum) seed meal protein with supplemental amino acids in feeds for rohu, Labeo rohita (Hamilton) fingerlings 显示文摘 | Mukhopadhyay N Ray A K | 1999 | Aquaculture Research1999，30，8： | 1 |
| 19 | Measurements and correlations of the physical of CO_Wheavy crude oil mixtures显示文摘 | Chung Frank T H Jones Ray A Nguyen Hai T | 1988 | SPE Reservoir Engi- neering1988，40，8： | 1 |
| 20 | Association between percutaneous coronary intervention and long-term (2-reactive protein levels in patients with acute coronary syndromes显示文摘 | Ray K K Nazer B Cairns R ct a| | 2010 | J Thromb Thrombolysis2010，30，1： | 1 |
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