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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | Alcohol-induced hypertension: Mechanism and prevention显示文摘Epidemiological, preclinical and clinical studies es-tablished the association between high alcohol con-sumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been pro-posed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angio-tensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracel-lular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflamma-tion and oxidative injury of the endothelium by angio-tensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise trainingis one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme(ACE) inhibitors or angiotensin Ⅱ type 1 receptor blockers(ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the | Kazim Husain Rais A Ansari Leon Ferder | 2014 | World Journal of Cardiology2014，6，5： | 8 |
| 3 | Simulation model for electron irradiated IGZO thin film transistors显示文摘An efficient drain current simulation model for the electron irradiation effect on the electrical parameters of amorphous In–Ga–Zn–O(IGZO) thin-film transistors is developed. The model is developed based on the specifications such as gate capacitance, channel length, channel width, flat band voltage etc. Electrical parameters of un-irradiated IGZO samples were simulated and compared with the experimental parameters and 1 kGy electron irradiated parameters. The effect of electron irradiation on the IGZO sample was analysed by developing a mathematical model. | G K Dayananda C Shantharama Rai A Jayarama Hyun Jae Kim | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 4 | Nonlinear control of U-tube steam generators via H∞ control显示文摘 | PARLOS A G RAIS O T | 2000 | Control Engineering Practice2000，29，8： | 1 |
| 5 | Effect of fluid loading with saline or colloids on pulmonary permeability,oedema and lung injury score after cardiac and major vascular surgery显示文摘 | Verhei J Van Lingen A Rai jmakers PG | 2006 | Br J Anaesth2006，96，1： | 1 |
| 6 | Tenascin is differentially expressed in endometrium and endometriosis显示文摘 | Harrington D J lessey B A Rai V | 1999 | J pathol1999，187，2： | 1 |
| 7 | Characterization of microstructures in Inconel 625 using X-ray diffraction peak broad- ening and lattice parameter measurements显示文摘 | RAI S K KUMAR A SHANKAR V | 2004 | Scripta Materialia2004，51，1： | 1 |
| 8 | Positive growth responses of the medicinal plants Spilanthes calva and Withania somnifera to inoculation by Piriformospora indica in a field trial显示文摘 | Rai M Acharya D Singh A | 2001 | Myeorrhiza2001，11，： | 1 |
| 9 | Importance of phase change of aluminum in oxidation of aluminum particles 显示文摘 | Rai A Lee D Park K | 2004 | Journal of Physical Chemistry2004，108，14： | 1 |
| 10 | Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings显示文摘 | RAI A PRABHUNE A PERRY C C | 2010 | Journal of Materials Chemistry2010，20，32： | 1 |
| 11 | Identification of genes involved in bamboo fiber development显示文摘 | Rai V Ghosh J S Pal A | | 0，，1： | 1 |
| 12 | Effect of coherent to incoherent structural transition on magnetic anisotropy in Co/Pt muhilayers 显示文摘 | Chowdhury P Kulkkarni P D Krishnan M Barshilia H C Sagdeo A Rai S K Lodha G S Rao D V S | 2012 | Journal of Applied Physics2012，112，02： | 1 |
| 13 | Remifentanil targetcon- trolled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded random- ized controlled trial显示文摘 | Rai MR Parry TM Dombrovskis A | 2008 | Br J Anaesth2008，100，1： | 1 |
| 14 | How software project risk affects project performance: An investigation of the di- mensions of risk and an exploratory model显示文摘 | Wallace L Keil M Rai A | 2004 | Decision Sciences2004，35，2： | 1 |
| 15 | Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain,optic nerve and retina显示文摘 | Rai N K Ashok A Rai A Tripathi S Nagar G K Mitra K | 2013 | Toxicology and Applied Pharmacology2013，273，2： | 1 |
| 16 | Pyonephro is and treatment:report of 14 cases显示文摘 | Joual A Rais H | 2000 | Ann Urol2000，34，： | 1 |
| 17 | Understanding Software Project Risk:A Cluster Analysis显示文摘 | KEIL M RAI A | 2004 | Information and Management2004，42，1： | 1 |
| 18 | Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds显示文摘 | Rai S Wahile A Mukherjee K | 2006 | J Ethnopharmacology2006，104，： | 1 |
| 19 | Comparison of single vs double noncompression mini- plates in the management of subeondylar fracture of the mandi- ble显示文摘 | Rai A | 2012 | Ann Maxillofae Surg2012，2，2： | 1 |
| 20 | An objective assess- ment of demography of gallbladder cancer显示文摘 | Kumar JR Tewari M Rai A | 2006 | J Surg On- col2006，93，8： | 1 |
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