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| 1 | Parental transmission of type 2 diabetes mellitus in a highly endogamous population显示文摘AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes. | Abdulbari Bener Mohammad T Yousafzai Abdulla OAA Al-Hamaq Abdul-Ghani Mohammad Ralph A DeFronzo | 2013 | World Journal of Diabetes2013，4，2： | 28 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 4 | 气相多环芳烃的吸附净化技术研究进展显示文摘多环芳烃(PAHs)是近年来在大气污染问题中逐渐受到关注的一类污染物,不仅其自身严重威胁着人体健康,还可作为低挥发性物质促进二次颗粒物的生长.世界多国开始不断通过各种技术手段对废气中PAHs的排放进行控制,PHAs已成为大气环境领域共同关注的热点问题.吸附法是最具潜力且已被工业应用认可的一类PAHs控制净化关键技术,吸附剂对PAHs的吸、脱附性能是其中的关键.目前国内外学者无论是基于传统碳类吸附剂,还是新型的介孔吸附剂,都针对此类特殊低挥发性气体的吸附相平衡、动力学以及脱附特性做了相关研究,探悉了获取PAHs吸脱附最优平衡的关键因素以及最适吸附剂.本文针对这些结果及相关应用进行了综述,对比分析了介孔吸附剂较传统吸附剂在PAHs吸脱附特性上呈现的优势,旨在为PAHs及其他低挥发性气体吸附净化的相关工作提供有效参考. | 李子宜 刘应书 姜理俊 孟苗苗 杨雄 Ralph T Yang | 2018 | 工程科学学报2018，40，2： | 2 |
| 5 | The formation and early differentiation of sea urchin gonads显示文摘 | Houk Margaret S Hingardner Ralph T | 1980 | Biological Bulletin1980，159，： | 1 |
| 6 | The fusarium wilt resistance locus Fom-2 of melon contains a single resistance gene with complex features显示文摘 | TAREK J JOSEPH J K SHELLY J N CLAUDE E T RALPH A D | 2004 | The Plant Journal2004，39，： | 1 |
| 7 | Proton Exchange Membrane Fuel Cell显示文摘 | Ralph T R | 1997 | Platinum Metals Review1997，41，3： | 1 |
| 8 | Desulfurization of jet fuel by π-complexation adsorption with metal halides supported on MCM-41 and SBA-15 mesoporous materials显示文摘 | Yuhe W Ralph T Y John M | 2007 | Chemical engineering science2007，52，3： | 1 |
| 9 | Denitrogenation of transportation fuels by zeolites at ambient temperature and pressure 显示文摘 | Hemndez-Maldonado J Ralph T Yang | 2004 | Angew Chem Int Ed2004，43，： | 1 |
| 10 | Adsorption of gases on coals and heattreated coals at elevated temperature andpressure 显示文摘 | Ralph T Yang John T Saunders | 1985 | Fuel1985，64，： | 1 |
| 11 | Riociguat for the treatment of pulmonary hypertension显示文摘 | Ralph T Schermuly Wiebke Janssen Norbert Weissmann Johannes-Peter Stasch Friedrich Grimminger Hossein Ardeschir Ghofrani | 2011 | Expert Opinion on Investigational Drugs2011，，4： | 1 |
| 12 | Heralded noiseless linear am- plification and distillation of entanglement 显示文摘 | Xiang G Y Ralph T C | 2010 | Nature Photonics2010，4，5： | 1 |
| 13 | Tailored clinoptilolites for nitrogen/methane separation显示文摘 | Jayaraman Ambalavanan Yang Ralph T | 2005 | Ind Eng Chem Res2005，44，14： | 1 |
| 14 | Low cost electrodes for proton exchange membrane fuel cells 显示文摘 | Ralph T R Hards G A Keating J E | 1997 | J Electrochem Soc1997，144，11： | 1 |
| 15 | Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer显示文摘 | Ralph P Nadine W Thomas T | 2008 | In Vivo2008，22，1： | 1 |
| 16 | 显示文摘 | Ralph T R Hogarth M P | 2002 | Platinum Metals Rev2002，46，1： | 1 |
| 17 | 显示文摘 | Salil U Rege Ralph T | 1998 | AIChE Journal1998，44，7： | 1 |
| 18 | Hydrogen storage in graphite nanofibers:Effect of synthesis catalyst and pretreatment conditions显示文摘 | Angela D Ralph T Nelly M | 2004 | Langmuir2004，20，3： | 1 |
| 19 | MnOx-CeO2 mixed oxides prepared by co-precipitation for selective catalytic reduction of NO with NH3 at low temperatures显示文摘 | Qi Gongshin Yang Ralph T Ramsay Chang | 2004 | Applied Catalysis B:Environmental2004，51，2： | 1 |
| 20 | MN0x-Ce02mixed oxides prepared by co-precipitation for selective cat-alytic reduction of NO with NH3 at low temperatures 显示文摘 | Qi Gongshin Yang Ralph T Chang Ramsay | 2004 | Applied Catalysis B : Environmental2004，51，： | 1 |
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