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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 3 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 4 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 5 | Assessment of the SARS-CoV-2 basic reproduction number,R0,based on the early phase of COVID-19 outbreak in Italy显示文摘As of March 12th Italy has the largest number of SARS-CoV-2 cases in Europe as well as outside China.The infections,first limited in Northern Italy,have eventually spread to all other regions.When controlling an emerging outbreak of an infectious disease it is essential to know the key epidemiological parameters,such as the basic reproduction number R0,i.e.the average number of secondary infections caused by one infected individual during his/her entire infectious period at the start of an outbreak.Previous work has been limited to the assessment of R0 analyzing data from the Wuhan region or China's Mainland.In the present study the R0 value for SARS-CoV-2 was assessed analyzing data derived from the early phase of the outbreak in Italy.In particular,the spread of SARS-CoV-2 was analyzed in 9 cities(those with the largest number of infections)fitting the well-established SIR-model to available data in the interval between February 25–March 12,2020.The findings of this study suggest that R0 values associated with the Italian outbreak may range from 2.43 to 3.10,confirming previous evidence in the literature reporting similar R0 values for SARS-CoV-2. | Marco D'Arienzo Angela Coniglio | 2020 | Biosafety and Health2020，2，2： | 6 |
| 6 | Smad3 knock-out mice as a useful model to study intestinal fibrogenesis显示文摘瞄准:为了在形态学和免疫评估可能的差别, CD3,转变生长因素 beta1 (TGF-beta1 ) , Smad7, alpha 光滑的肌肉肌动朊(alpha-Sma ) ,和骨胶原的组织化学的表示打 I-VII 小并且在 Smad3 空、野类型的老鼠的大肠。方法:十 0 和十只野类型的成年老鼠在年龄和机关的 4 瞬间被牺牲(食管,小、大的肠,输尿管) 为组织学被收集(苏木精和曙红,马森 thrichrome,染色的银) ,形态测定法和免疫组织化学分析。肠的织物 homogenates 的 TGF-beta1 层次被 ELISA 估计。结果:没有宏观的肠的损害在空、野类型的老鼠两个都被检测。组织学并且 morphometric 评估在肌肉层厚度揭示了重要减小小并且在空老鼠的大肠同样与野类型的老鼠相比。Immunohistochemistry 评估显示出染色在的 CD3+ T 房间, TGF-beta1 和 Smad7 的重要增加小并且 Smad3 空老鼠的大肠粘膜同样与野类型的老鼠相比。染色的 Alpha-Sma 和骨胶原 I-VII 小并且大肠没在二组老鼠之间不同。结肠的织物 homogenates 的 TGF-beta1 层次比在野类型的老鼠在空老鼠是显著地更高的。在初步的实验,导致 TNBS 的肠的纤维变性的重要减小作为与野类型的老鼠相比在空老鼠被观察。结论:Smad3 空老鼠是一个有用模型调查在肠的发炎和纤维变性表明小径的 TGF-beta/Smad 的在活体内角色。 | Giuliana Zanninelli Antonella Vetuschi Roberta Sferra Angela D'Angelo Amato Fratticci Maria Adelaide Continenza Maria Chiaramonte Eugenio Gaudio Renzo Caprilli Giovanni Latella | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 7 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 8 | Optimization of the magnetic properties of nanocrystalline Pr5Fe77-xCrxB18 alloys 显示文摘 | Angela D | 2001 | J Magn Magn Mater2001，，： | 2 |
| 9 | Clinical profile of diabetes at diagnosis among children and adolescents at an endocrine clinic in Ghana显示文摘AIM To determine the clinical features of diabetes in children and adolescents in Ghana.METHODS Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS One hundred and six subjects presented with diabetes. Ninety(84.9%) were diagnosed by clinical features and family history as type 1, and 16(15.1%) type 2. For type 1 subjects, age range at diagnosis was 0.9-19.9 year(y), peak age of onset 12-13 year, and 3.3% were < 5 year, 21.1% 5-< 10 year, 45.6% 10-< 15 year and 30.0% 15-< 20 year. Seventy-one point one percent were female. Common clinical features were polyuria(100%), polydipsia(98.9%), and weight loss(82.2%). Mean BMI SD was -0.54, range -3.84 to 2.47. 60.0% presented in diabetic ketoacidosis(DKA). Nine had infections at onset(skin, abscess, leg ulcer). Mean± SD HbA 1c at diagnosis was 12.7% ± 1.9%(115±21 mmol/mol). Four have since died: Hypoglycaemia(2), recurrent DKA(1), osteosarcoma(1). Two other type 1 cases died of DKA at presentation in emergency before being seen by the paediatric endocrinologist. Crude mortality rate including these 2 cases was 32.2/1000 patient years. Type 2 cases were 81% female, age of onset 9-19 year. Mean BMI SD was 1.49, range -0.87 to 2.61. Forty-three point eight percent presented in DKA. All type 2 cases had acanthosis nigricans. Overall, 9.8% did not have home refrigeration, most using clay pot evaporative cooling for insulin storage. CONCLUSION Type 1 occurs with a female preponderance and high DKA rates. Type 2 also occurs. Typology based on clinical features is difficult. Community and professional awareness is warranted. | Emmanuel Ameyaw Serwah B Asafo-Agyei Sumithira Thavapalan Angela C Middlehurst Graham D Ogle | 2017 | World Journal of Diabetes2017，8，9： | 2 |
| 10 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 11 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 12 | Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment显示文摘 | Elena De Mattia Giuseppe Toffoli Jerry Polesel Mario D’Andrea Giuseppe Corona Vittorina Zagonel Angela Buonadonna Eva Dreussi Erika Cecchin | 2013 | Pharmacogenetics and Genomics2013，，10： | 2 |
| 13 | From the archives of the AFIP gastrointestinal stromal tumors: radiologic features with pathologic correlation 显示文摘 | Angela D Helen E William M | 2003 | Radio Graphics2003，23，： | 1 |
| 14 | Periphral blood stem cell transplantation (PBSCT) in patients with POEMS syndrome显示文摘 | Angela D | | Autologous transplantation0，，： | 1 |
| 15 | Endoscopic ultrasound-guided fine needle aspiration with 22- and 25-gauge needles in solid pancreatic masses: A prospective comparative study with randomisation of needle sequence显示文摘 | Carlo Fabbri Anna Maria Polifemo Carmelo Luigiano Vincenzo Cennamo Paola Baccarini Guido Collina Adele Fornelli Sandro Macchia Nicola Zanini Elio Jovine Marta Fiscaletti Angela Alibrandi Nicola D’Imperio | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 16 | Rational Sirna Design for RNA Interference显示文摘 | ANGELA R LEAKE D BOESE Q | | 0，，03： | 1 |
| 17 | Chitosan/whey protein film as active coating to extend Rieotta cheese shelf-life 显示文摘 | Prospero D P Angela S Loredana M | 2011 | LWT-Food Science and Technology2011，44，： | 1 |
| 18 | A High Index of Suspicion: The Key to an Early Diagnosis of Wilson’s Disease in Childhood显示文摘 | Icíar Sánchez-Albisua Teresa Garde Loreto Hierro Carmen Camarena Esteban Frauca Angela de la Vega María Carmen Díaz Javier Larrauri Paloma Jara | 1999 | Journal of Pediatric Gastroenterology & Nutrition1999，，2： | 1 |
| 19 | Auditory Language Comprehension:An Event-Related fMRI Study on the Processing of Syntactic and Lexical Information显示文摘 | | 2000 | Brain and Language2000，74，： | 1 |
| 20 | Hypervelocity Impact Testing of Pressure Vessels to Simulate Spacecraft Failure 显示文摘 | Greory D O Angela M N | 2001 | Int J Impact Eng2001，26，： | 1 |
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