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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 3 | Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes显示文摘光力学的治疗(太平洋夏季时间) 是 tumorlocalized photosensitizer 与光是激动的一种肿瘤治疗在形式,它导致反应的氧种类,肿瘤 vasculature 的破坏,肿瘤组织缺氧,肿瘤房间死亡,和反肿瘤免疫者回答的正式就职的本地生产。然而,先存在肿瘤组织缺氧可以减少肿瘤到由激活组织缺氧可诱导的因素的太平洋夏季时间 1 (HIF-1 ) 幸存小径。因此,我们与吖啶黄(ACF ) 假设了 HIF-1 的那抑制将在人的表皮状的癌(A431 ) 加重房间死亡房间。A431 肿瘤房间的太平洋夏季时间用包含 photosensitizer 锌酞毒(ZnPC ) 的最新发达并且优化的 PEGylated cationic liposomes 被执行。分子的停靠表明 ACF 绑在 HIF-1 的 dimerization 领域,并且共焦的显微镜学在组织缺氧下面从 cytosol 证实了 ACF 的 translocation 到原子核。HIF-1 在 hypoxic,然而并非 normoxic 被稳定, A431 房间列在后面太平洋夏季时间。有 ACF 的 HIF-1 的抑制在 hypoxic 条件下面增加了导致太平洋夏季时间的房间死亡的程度并且减少了 HIF-1 目标基因 VEGF, PTGS2,和 EDN1 的表示。而且,在包含 ZnPC liposomes 的水的核心的 ACF 的合作封装在比得上非包含的 ACF 的太平洋夏季时间功效上产出辅助效果。在结论, HIF-1 与 liposomal ZnPC 贡献 A431 肿瘤房间幸存追随者太平洋夏季时间。HIF-1 与的抑制免费或 liposomal ACF 改进太平洋夏季时间功效。 | Mans Broekgaarden Ruud Weijer Massis Krekorian Bas van den IJssel Milan Kos Lindy K. Alles Albert C. van Wijk1 Zsolt Bikadi Eszter Hazai Thomas M. van Gulik Michal Heger | 2016 | Nano Research2016，9，6： | 4 |
| 4 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 5 | Advances in scalable gas-phase manufacturing and processing of nanostructured solids: A review显示文摘 | Samir Salameh Jesus Gomez-Hernandez Aristeidis Goulas Hao Van Bui J. Ruud van Ommen | 2017 | Particuology2017，15，1： | 3 |
| 6 | Model for end-stage liver disease (MELD) and allocation of donor livers显示文摘 | Russell Wiesner Erick Edwards Richard Freeman Ann Harper Ray Kim Patrick Kamath Walter Kremers John Lake Todd Howard Robert M. Merion Robert A. Wolfe Ruud Krom | 2003 | Gastroenterology2003，，1： | 2 |
| 7 | 广泛经皮针刀筋膜切断术联合脂肪移植术:一种治疗掌腱膜挛缩的新疗法显示文摘背景手术切除治疗掌腱膜挛缩症复发率高且康复时间延长。本文将介绍一种新型微创手术替代治疗掌腱膜挛缩症的方法及其成果。方法过程包括采用广泛经皮针刀筋膜切断术将束带完全松解,并与真皮分离。随后,由此产生的松弛组织用以自体脂肪填充。术后伸直位制动1周,然后,建议术后3~6个月患者白天可以正常用手,夜间伸直位固定。本组患者共91例(99只手),手术在迈阿密和鹿特丹进行;对50例患者的手部伸展角度进行测量(平均随访44周)。结果近端指间关节挛缩的治疗效果显著,伸展角度由61°改善至27°,掌指关节挛缩的伸展角度由37°改善至-5°。94%患者在2~4周内手部恢复正常功能,95%患者对结果非常满意。无新的瘢痕生成,大部分恢复了柔软的手掌脂肪垫。发生了1例神经损伤的并发症,1例术后切口感染,4例复杂区域疼痛综合征。结论这一新的微创技术缩短了康复时间,增加了缺损的皮下脂肪组织,产生了柔软无痕的皮肤。并且有能力处理多个掌指纹,可解决整只手的异常情况。治疗过程安全有效,尤其对首次治疗者。目前,前瞻性随机对照研究过程充分确定了其治疗掌腱膜挛缩症的作用。(循证医学证据等级:Ⅳ级,疗法) | Steven E. R. Hovius Hester J. Kan Xander Smit Ruud Wf Selles Eufimiano Cardoso Roger K. Khouri 李可竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) | 2013 | 中国美容整形外科杂志2013，24，1： | 2 |
| 8 | Anxiety enhances the detrimental effect of depressive symptoms on health status following percutaneous coronary intervention显示文摘 | Susanne S. Pedersen Johan Denollet Helle Spindler Andrew T.L. Ong Patrick W. Serruys Ruud A.M. Erdman Ron T. van Domburg | 2006 | Journal of Psychosomatic Research2006，，6： | 2 |
| 9 | Pressure ulcer prevalence and incidence in intensive care patients: a literature review显示文摘 | Eman SMShahin TheoDassen Ruud JGHalfens | 2008 | Nursing in Critical Care2008，，2： | 2 |
| 10 | T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression. | Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens | 2014 | World Journal of Nephrology2014，3，4： | 2 |
| 11 | Environmental tax reform and endogenous growth显示文摘 | A Lans Bovenberg Ruud A de Mooij | 1997 | Journal of Public Economics1997，，2： | 2 |
| 12 | 2-D finite-difference elastic wave modeling including surface topography显示文摘 | Hestholm S O Ruud B O | 1994 | Geophys Prosp1994，42，2： | 2 |
| 13 | Optical Rotation Studied by Density-functional and Coupled-cluster Methods显示文摘 | RUUD K HELGAKER T | 2002 | Chemical Physics Letters2002，352，： | 1 |
| 14 | Movements and Media: Selection Processes and Evolutionary Dynamics in the Public Sphere 显示文摘 | Koopmans Ruud | 2004 | Theory and Society2004，33，3： | 1 |
| 15 | 2D finite-difference elastic wave modeling including surface topograph显示文摘 | Hestholm S Ruud B | 1994 | Geophysical Prospecting1994，42，： | 1 |
| 16 | Segmental testicular infarction due to sickle cell disease显示文摘 | Gofrit ON Ruud D Shapiro A | 1998 | J Urol1998，160，31： | 1 |
| 17 | Simple Heuristics for Push and Pull Remanufacturing Policies 显示文摘 | Erwin A Vander Laan Ruud H Teunter | 2006 | European Journal of Operational Research2006，，175： | 1 |
| 18 | Development and validation of ultrasound speckle tracking to quantify tendon displacement 显示文摘 | Jan W H K Ruud W S Henk J S | 2012 | Journal of Biomechanics2012，43，7： | 1 |
| 19 | The newsboy problem with resalable returns: a single period model and case study显示文摘 | Mostard Julien Teunter Ruud | 2006 | European Journal of Operational Research2006，169，1： | 1 |
| 20 | Heterogeneous growth of microcrystalline silicon germanium显示文摘 | Rath Jatindra K Tichelaar F D Schropp Ruud E I | 2002 | Solar Energy Materials & Solar Cells2002，74，14： | 1 |
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