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| 1 | Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness. | Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 8 |
| 2 | Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes显示文摘The asparagine-X-serine/threonine (NXS/T) motif, where X is any amino acid except proline, is the consensus motif for N-linked glycosylation. Significant numbers of high-resolution crystal structures of glycosylated proteins allow us to carry out structural analysis of the N-linked glycosylation sites (NGS). Our analysis shows that there is enough structural information from diverse glycoproteins to allow the development of rules which can be used to predict NGS. A Python-based tool was developed to investigate asparagines implicated in N-glycosylation in five species: Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana and Saccharomyces cerevisiae. Our analysis shows that 78% of all asparagines of NXS/T motif involved in N-glycosylation are localized in the loop/turn conformation in the human proteome. Similar distribution was revealed for all the other species examined. Comparative analysis of the occurrence of NXS/T motifs not known to be glycosylated and their reverse sequence (S/TXN) shows a similar distribution across the secondary structural elements, indicating that the NXS/T motif in itself is not biologically relevant. Based on our analysis, we have defined rules to determine NGS. Using machine learning methods based on these rules we can predict with 93% accuracy if a particular site will be glycosylated. If structural information is not available the tool uses structural prediction results resulting in 74% accuracy. The tool was used to identify glycosylation sites in 108 human proteins with structures and 2247 proteins without structures that have acquired NXS/T site/s due to non-synonymous variation. The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://gffzzd6cb8b41b64c4e07h5nxquxxv9w556kn6.ffgz.tsg.suse.edu.cn/tools/sfat. | Phuc Vinh Nguyen Lam Radoslav Goldman Konstantinos Karagiannis Tejas Narsule Vahan Simonyan Valerii Soika Raja Mazumder | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 8 |
| 3 | Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | Habtom W. Ressom Jun Feng Xiao Leepika Tuli Rency S. Varghese Bin Zhou Tsung-Heng Tsai Mohammad R. Nezami Ranjbar Yi Zhao Jinlian Wang Cristina Di Poto Amrita K. Cheema Mahlet G. Tadesse Radoslav Goldman Kirti Shetty | 2012 | Analytica Chimica Acta2012，，： | 2 |
| 4 | Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib显示文摘 | Anja Lachenmayer Clara Alsinet Radoslav Savic Laia Cabellos Sara Toffanin Yujin Hoshida Augusto Villanueva Beatriz Minguez Philippa Newell Hung-Wen Tsai Jordi Barretina Swan Thung Stephen C. Ward Jordi Bruix Vincenzo Mazzaferro Myron Schwartz Scott L. Fri | 2012 | Clinical Cancer Research2012，，18： | 2 |
| 5 | 初级保健中恶性肿瘤早期诊断的预警症状:运用全科医疗机构研究数据库进行的队列研究显示文摘目的根据初级保健中的研究,评价在大规模人群中预警症状与随后的恶性肿瘤诊断之间的关系。设计队列研究。地点英国全科医疗机构研究数据库。患者 1994至2000年间在英国128家全科医疗机构注册的762325名年龄在15岁及以上的患者。既往无恶性肿瘤病史,首次出现血尿、咯血、吞咽困难或直肠出血症状。结局评估指标首次出现的血尿、咯血、吞咽困难或直肠出血症状,自症状出现3年内,在泌尿道、呼吸道、食管、结肠以及直肠等部位恶性肿瘤诊断中的阳性预测值。同时评价其似然比和敏感性。结果在11108名首发血尿患者中,有472名男性和162名女性新近诊断泌尿道恶性肿瘤,总的3年阳性预测值男性为7.4%(95%可信区间为6.8%~8.1%),女性为3.4%(2.9%~4.0%)。在4812名首发咯血患者中,有220名男性(阳性预测值7.5%,6.6%~8.5%)和81名女性(4.3%,3.4%~5.3%)诊断呼吸道恶性肿瘤。5999名首次出现吞咽困难的患者中,食管恶性肿瘤诊断在男性有150人(阳性预测值5.7%,4.9%~6.7%),女性有81人(2.4%,1.9%~3.0%)。在15289名首发直肠出血症状的患者中,则有184名男性(阳性预测值2.4%,2.1%~2.8%)和154名女性(2.0%,1.7%~2.3%)诊断结直肠恶性肿瘤。预测值随着患者年龄的增加而增加,而且值非常高,例如,年龄在75~84岁的男性咯血患者(17.1%,13.5%~21.1%)和年龄在65~74岁的男性吞咽困难患者(9.0%,6.8%~11.7%)。结论首次出现预警症状时恶性肿瘤诊断可能性增加,尤其在男性及年龄大于65岁的患者人群中。这些数据显示,对于预警症状进行早期评价有助于在早期或易于处理的阶段发现或鉴别恶性肿瘤。 | Roger Jones Radoslav Latinovi Judith Charlton Martin C Gulliford 张国庆 | 2007 | 英国医学杂志中文版2007，10，5： | 2 |
| 6 | In fluence of hydraulic oil on the hydraulic system failures 显示文摘 | Rakic Radoslav | 2000 | Tribologia2000，19，1： | 1 |
| 7 | Order bispeetrum:a new tool for re-ciprocated machine condition monitoring 显示文摘 | Dusan Kocur Radoslav Stanko | 2000 | Mechmlical Systemsand Signal Processing2000，14，6： | 1 |
| 8 | Ultrasoundassisted extraction in the fractionation analysis of gravitation dust sediments 显示文摘 | Dagmar Remeteiova Silvia Ruzickova Radoslav Rusnak | 2008 | Microchim Acta2008，163，34： | 1 |
| 9 | The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors 显示文摘 | L'ubos D Ivan V Radoslav Z | 2012 | Exper Biol Med2012，237，1： | 1 |
| 10 | Order bispectrum: a new tool for reciprocated machine condition monitoring显示文摘 | Dusan Kocur Radoslav Stanko | 2000 | Mechanical Systems and Signal Processing2000，14，6： | 1 |
| 11 | Hydrogen‐Evolution Catalysts Based on Non‐Noble Metal Nickel–Molybdenum Nitride Nanosheets显示文摘 | Wei‐Fu Chen Kotaro Sasaki Chao Ma Anatoly I. Frenkel Nebojsa Marinkovic James T. Muckerman Yimei Zhu Radoslav R. Adzic | 2012 | Angew Chem Int Ed2012，，25： | 1 |
| 12 | Aluminothermic powder bofiding of steel显示文摘 | Nikolay U Radoslav I | 2004 | Applied Surface Science2004，225，： | 1 |
| 13 | Micellar nanocotainers distribute to defined cytoplasmic organelles 显示文摘 | Radoslav S Luo L B Eisenberg A | 2003 | Science2003，300，25： | 1 |
| 14 | Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib显示文摘 | Anja Lachenmayer Clara Alsinet Radoslav Savic Laia Cabellos Sara Toffanin Yujin Hoshida Augusto Villanueva Beatriz Minguez Philippa Newell Hung-Wen Tsai Jordi Barretina Swan Thung Stephen C. Ward Jordi Bruix Vincenzo Mazzaferro Myron Schwartz Scott L. Fri | 2012 | Clinical Cancer Research2012，，18： | 1 |
| 15 | Immunological monitoring in patients with end-stage renal disease显示文摘 | Wayne C. Waltzer Radoslav J. Bachvaroff Audrey P. Raisbeck Bjorg Egelandsdal Christopher Pullis Liling Shen Felix T. Rapaport | 1984 | Journal of Clinical Immunology1984，，5： | 1 |
| 16 | Order bispeetrum: a new tool for re- ciprocated machine condition monitoring显示文摘 | Dusan K Radoslav S | 2000 | Mechanical Systems and Signal Processing2000，14，6： | 1 |
| 17 | Study of Biofilm Formed by Lactic Acid Bacteria on the Surface of Mild Steel显示文摘 | Tsveteslava Veselinova Ignatova-Ivanova Radoslav Iliev Ivanov | 2014 | Journal of Life Sciences2014，8，10： | 1 |
| 18 | Order bispectrum: a new tool for reciprocated machine condition monitoring 显示文摘 | K Dusan S Radoslav | 2000 | Mechanical Systems and Signal Processing2000，14，6： | 1 |
| 19 | Influence of formation conditions and precursor viscosity on mean fiber diameter formod using the rota- ting disk meathod 显示文摘 | Radmila Jancic Radoslav Aleksic | 2000 | Materials Letters2000，，42： | 1 |
| 20 | ORDER BISPECTRUM: A NEW TOOL FOR RECIPROCATED MACHINE CONDITION MONITORING显示文摘 | DU?AN KOCUR RADOSLAV STANKO | 2000 | Mechanical Systems and Signal Processing2000，，6： | 1 |
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