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| 1 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 2 | Galectin-3 and IL-33/ST2 axis roles and interplay in dietinduced steatohepatitis显示文摘Immune reactivity and chronic low-grade inflammation(metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease(NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis(NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death. Experimental models of dietary-induced NAFLD/NASH in mice on different genetic backgrounds or knockout mice with different immune reactivity are used for elucidating the pathogenesis of NASH and liver fibrosis. Galectin-3(Gal-3), a unique chimera-type β-galactoside-binding protein of the galectin family has a regulatory role in immunometabolism and fibrogenesis. Mice deficient in Gal-3 develop pronounced adiposity, hyperglycemia and hepatic steatosis, as well as attenuated liver inflammation and fibrosis when fed an obesogenic high-fat diet. Interleukin(IL)-33, a member of the IL-1 cytokine family, mediates its effects through the ST receptor, which is present on immune and nonimmune cells and participates in immunometabolic and fibrotic disorders. Recent evidence, including our own data, suggests a protective role for the IL-33/IL-33R(ST2) signaling pathway in obesity, adipose tissue inflammation and atherosclerosis, but a profibrotic role in NASH development. The link between Gal-3 and soluble ST2 in myocardial fibrosis and heart failure progression has been demonstrated and we have recently shown that Gal-3 and the IL-33/ST2 pathway interact and both have a profibrotic role in diet-induced NASH. This review discusses the current evidence on the roles of Gal-3 and the IL-33/ST2 pathway and their interplay in obesity-associated hepatic inflammation and fibrogenesis that may be of interest in the development of therapeutic interventions to prevent and/or reverse obesity-associated hepatic inflammation and fibrosis. | Nada Pejnovic Ilija Jeftic Nemanja Jovicic Nebojsa Arsenijevic Miodrag L Lukic | 2016 | World Journal of Gastroenterology2016，22，44： | 9 |
| 3 | Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension显示文摘AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension.METHODS:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the study.Liver di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler detection.Cross-section area,portal flow and index of vascular resistance were calculated.In collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were determined.Time-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) administration.RESULTS:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate level.Consequently O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid peroxidation.Increased blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood flow.CONCLUSION:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension. | Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric | 2012 | World Journal of Gastroenterology2012，18，4： | 7 |
| 4 | Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression显示文摘BACKGROUND Ulcerative colitis(UC)is a chronic disease characterized by inflammation of intestinal epithelium,primarily of the colon.An increasing prevalence of metabolic syndrome(MetS)in patients with UC has been documented recently.Still,there is no evidence that MetS alters the course of the UC.AIM To test the influence of the MetS on the severity of UC and the local and systemic immune status.METHODS Eighty nine patients with de novo histologically confirmed UC were divided in two groups,according to ATP III criteria:Group without MetS(no MetS)and group with MetS.RESULTS Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10(IL-10)and fecal content of Galectin-3(Gal-3)was observed in subjects with UC and MetS,compared to subjects suffering from UC only.This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factorα(TNF-α),interleukin-6(IL-6),and interleukin-17(IL-17)in the sera as well as Gal-3 over TNF-αand IL-17 in feces of UC patients with MetS.Further,the patients with both conditions(UC and MetS)had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina propria.CONCLUSION Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC. | Marina Jovanovic Bojana Simovic Markovic Nevena Gajovic Milena Jurisevic Aleksandar Djukic Ivan Jovanovic Nebojsa Arsenijevic Aleksandra Lukic Natasa Zdravkovic | 2019 | World Journal of Gastroenterology2019，25，43： | 5 |
| 5 | Effect of heat treatment on structure and magnetic properties of Fe65.5Cr4Mo4Ga4P12C5B5.5 bulk amorphous alloy显示文摘This study deals with the Fe65.5Cr4Mo4Ga4P12C5B5.5 ferromagnetic bulk amorphous alloy. XRD analysis showed an amorphous structure of the as-cast sample. The same method revealed that, after annealing at 973 K for τ=10 min, the sample displayed a crystalline structure with crystalline phases formed. The crystallization process of the alloy was examined by DTA analysis. It was shown that crystallization took place in the temperature range between 810 K and 860 K with the exo-maximum peak temperature at 846 K with a heating rate of 20 K·min-1. The method also showed that, at temperatures ranging from 753 K to 810 K, the alloy exhibited the properties of supercooled liquids. A correlation between heat-induced structural changes and magnetic properties of the alloy was determined by thermomagnetic measurements. Maximum magnetization M=3.7 Am2·kg-1 of the alloy was reached after its annealing at 733 K for τ=10 min. Upon annealing, the alloy exhibited a relaxed amorphous structure. Annealing the alloy above the crystallization temperature led to a decrease in bulk magnetization. After annealing at 973 K for τ=10 min, the bulk magnetization of the alloy was M'=0.45 Am2·kg-1. Accordingly, after crystallization and formation of new compounds, the magnetization of the alloy was decreased by a factor of about 7.7. The strength of the magnetic field applied during the measurements was H=10 k A·m-1. The samples were tested for changes in the microstructure and hardness of both the amorphous phase and the resulting crystalline phase. | Bratislav Cukic Nebojsa Mitrovic Aleksa Maricic | 2017 | China Foundry2017，14，1： | 4 |
| 6 | 恒电位电沉积银纳米枝晶晶体结构与形貌的关系(英文)显示文摘采用恒电位电解法用不同电解质、在不同过电位下获得银枝晶纳米结构,并用扫描电镜(SEM)技术和X射线衍射分析对所得粉末进行表征。采用硝酸盐电解质在极限扩散电流密度的平台范围内外,分别形成了银针状和蕨状枝晶。采用氨盐电解质时,在极限扩散电流密度的平台范围内外均形成了由近球形晶粒构成的银三维松树状枝晶。在半量子化水平上,银枝晶的形貌与其晶体结构相关。在极限扩散电流密度平台范围外的过电位条件下形成的松树状枝晶,其晶体取向从针状枝晶的强(111)面择优取向转变为球形晶粒的几乎随机取向,同时,所得粉末的比表面积显著增加。形成的银颗粒的平均晶粒尺寸在38~50 nm之间,证明了其纳米结构特征。 | Ljiljana AVRAMOVIC Evica R.IVANOVIC Vesna M.MAKSIMOVIC Miroslav M.PAVLOVIC Marina VUKOVIC Jasmina S.STEVANOVIC Nebojsa D.NIKOLIC | 2018 | Transactions of Nonferrous Metals Society of China2018，28，9： | 2 |
| 7 | Interleukin‐33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells显示文摘 | Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Jelena M. Pantic Marija Z. Milovanovic Nebojsa N. Arsenijevic Miodrag L. Lukic | 2014 | Int. J. Cancer2014，，： | 2 |
| 8 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 9 | 不同电解条件下制备铜粉的形貌及结晶学比较分析(英文)显示文摘研究不同析氢条件下恒电位电解法制备铜粉的过程。采用扫描电镜(SEM)、X射线衍射(XRD)、粒度分布(PSD)和比表面积测定(SSA)对铜粉进行表征。根据电解过程析氢量的大小,形成树枝状和菜花状两种类型的颗粒。当析氢量大到足以对近电极层中的流体动力学条件产生强烈影响时,形成菜花状颗粒,否则形成树枝状颗粒。虽然颗粒的宏观结构差异很大,但他们的微观结构却相似,也就是说,这两种颗粒在微观层面上都是由近似球形的Cu颗粒小团聚体组成;球状形貌的存在是造成两种颗粒中Cu晶粒随机取向的原因。菜花样颗粒的比表面积是树枝状颗粒的3倍以上,其粒径则比树枝状颗粒的小很多。由此可见,强析氢条件对于铜粉制备是有益的。 | Nebojsa D. NIKOLIC Ljiljana AVRAMOVIC Evica R. IVANOVIC Vesna M. MAKSIMOVIC Zvezdana BASCAREVIC Nenad IGNJATOVIC | 2019 | Transactions of Nonferrous Metals Society of China2019，29，6： | 2 |
| 10 | ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma显示文摘 | Ivan Jovanovic Gordana Radosavljevic Maja Mitrovic Vanda Lisnic Juranic Andrew N. J. McKenzie Nebojsa Arsenijevic Stipan Jonjic Miodrag L. Lukic | 2011 | Eur. J. Immunol2011，，： | 2 |
| 11 | Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma显示文摘AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed.RESULTS: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P<0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P>0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings. | Rajko Milosevic Milena Todorovic Bela Balint Miodrag Jevtic Miodrag Krstic Elizabeta Ristanovic Nebojsa Antonijevic Mirjana Pavlovic Maja Perunicic Milan Petrovic Biljana Mihaljevic | 2009 | World Journal of Gastroenterology2009，15，32： | 2 |
| 12 | IL-33/ST2 axis in innate and acquired immunity to tumors显示文摘 | Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Nebojsa N. Arsenijevic Miodrag L. Lukic | 2012 | OncoImmunology2012，，： | 2 |
| 13 | The roles of Galectin-3 in autoimmunity and tumor progression显示文摘 | Gordana Radosavljevic Vladislav Volarevic Ivan Jovanovic Marija Milovanovic Nada Pejnovic Nebojsa Arsenijevic Daniel Hsu Miodrag Lukic | 2012 | Immunologic Research2012，，1： | 2 |
| 14 | The Role of Potassium Channels in the VasodilatationInducedby Resvera- trol and Naringenin in Isolated Human Umbilical Vein 显示文摘 | Protic Dragana R Nebojsa S Svetlana | 2015 | Drug Development Research2015，76，1： | 1 |
| 15 | Fractal and nonfractal properties of triadic Koch curve 显示文摘 | Milosevic Nebojsa T Ristanovic Dusan | 2007 | Chaos Solitons and Fractals2007，34，4： | 1 |
| 16 | Geominer: A system prototype for spatial data mining description of geominer system显示文摘 | Han Jiawei Stefanovic Nebojsa | 1997 | Communications of ACM1997，4，9： | 1 |
| 17 | Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis显示文摘 | Vladislav Volarevic Ahmed Al-Qahtani Nebojsa Arsenijevic Sladjana Pajovic Miodrag L. Lukic | 2009 | Autoimmunity2009，，4： | 1 |
| 18 | Le- thal outcome after intravenous administration of amio- darone in patient with atrial fibrillation and ventricular preexeitation显示文摘 | NEBOJSA M DRAGAN S NEBOJSA A | 2011 | J Cardiovase Electrophysiol2011，22，： | 1 |
| 19 | Fetal and maternal plasma endothelin levels during the second half pregnancy显示文摘 | Charles J Lockwood Manny Alvarez | 1995 | Am Obstet Gynecol1995，172，1： | 1 |
| 20 | Modeling Uncertainty of Induced Technological Change显示文摘 | Nebojsa Nakicenovic | 2000 | Energy Policy2000，，28： | 1 |
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