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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | RF thermal and new cold part design studies on a TTF-Ⅲ input coupler for Project-X显示文摘An RF power coupler is one of the key components in a superconducting (SC) linac. It provides RF power to the SC cavity and interconnects different temperature layers (1.8 K, 4.2 K, 70 K and 300 K). The TTF-Ⅲ coupler is one of the most promising candidates for the High Energy (HE) linac of Project X, but it cannot meet the average power requirements because of the relatively high temperature rise on the warm inner conductor, so some design modifications will be required. In this paper, we describe our simulation studies on the copper coating thickness on the warm inner conductor with RRR values of 10 and 100. Our purpose is to rebalance the dynamic and static loads, and finally lower the temperature rise along the warm inner conductor. In addition, to get stronger coupling, better power handling and less multipacting probability, one new cold part design was proposed using a 60 mm coaxial line; the corresponding multipacting simulation studies have also been investigated. | 裴士伦 Chris E Adolphsen 李增海 Nikolay A Solyak Ivan V Gonin | 2012 | Chinese Physics C2012，36，2： | 2 |
| 3 | Source Separation From Single Channel Recordings by Combining Empirical-Mode Decomposition and Independent Component Analysis显示文摘 | BOGDAN M MAARTEN D V IVAN G | | 0，，09： | 1 |
| 4 | Activated liver stellate cells in chronic viral C hepatitis:histopathological and immunohistochemical study 显示文摘 | Nada R T Ivan V B Dimitrije C B | 2009 | J Gastrointestin Liver Dis2009，18，2： | 1 |
| 5 | Modelling of residual stress relaxation around cold expanded holes in carbon steel显示文摘 | JORDAN T M GALYA V D IVAN N M | 2009 | Journal of Constructional Steel Research2009，65，： | 1 |
| 6 | Correlations between fractional flow reserve and intravascular ultrasound in patients with an ambigu- ous left main coronary artery stenosis 显示文摘 | Jasti V Ivan E Yalarnanchili V | 2004 | Circulation2004，110，18： | 1 |
| 7 | Laser doppler velocimeter for laboratory training 显示文摘 | IVAN V F BORIS L D ALEXEY S K | 2002 | Seventh international conference on education and training in optics and photonics New York Proceedings of SPIE2002，4588，： | 1 |
| 8 | Convenient,rapid synthesis of rare earth orthochromites LnCrO3by self-propagating high-temperature synthesis显示文摘 | Ivan P Parkin | 1998 | Polyhedron1998，17，2526： | 1 |
| 9 | The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors 显示文摘 | L'ubos D Ivan V Radoslav Z | 2012 | Exper Biol Med2012，237，1： | 1 |
| 10 | Epizootic occurrence of haemorrhagic nephritis enteritis virus infection of geese显示文摘 | Palya V Ivanics E Glavits R | 2004 | Avain Pathol2004，33，： | 1 |
| 11 | Correlations betweenfractional flow reserve and intravascular ultrasound in patientswith an ambigu- ous left main coronary artery stenosis 显示文摘 | Jasti V Ivan E Yalamanchili V | 2004 | Circulation2004，110，： | 1 |
| 12 | Correlations be- tween fractional flow reserve and intravascular ultrasound in patients with an ambiguous left main coronary artery stenosis 显示文摘 | JASTI V IVAN E YALAMANCHILI V | 2004 | Circulation2004，110，18： | 1 |
| 13 | Analysis of heat transfer in a vessel with helical pipe coil and multistage impeller 显示文摘 | Martin Dostál Marcela Vě?í?ová Karel Petera Tomá? Jirout Ivan Fo?t | 2014 | The Canadian Journal of Chemical Engineering2014，92，： | 1 |
| 14 | Cor- relations between fractional flow reserve and intravascularultrasound in patients with an ambiguous left main coronary artery显示文摘 | JASTI S V IVAN E YALAMANCHILI V | 2004 | Circulation2004，110，： | 1 |
| 15 | Photoinitiation of acrylamide polymerization by Fe2O3 nanoparticles 显示文摘 | Alexander L S Ivan V S Stephan Y K | 2007 | Journal of Photochemistry and Photobiology A: Chemistry2007，，： | 1 |
| 16 | Wire X--pinch in a high-current diode显示文摘 | Zakharov S M Ivan enkov G V Kolomenskii A A | 1982 | Soy Tech Phys Lett1982，8，9： | 1 |
| 17 | Correlations between fractional flow re- serve and intravascular ultrasound in patients with an ambiguous left main coro- nary artery stenosis 显示文摘 | Jasti V Ivan E Yalamanchili V | 2004 | Circulation2004，110，： | 1 |
| 18 | Anticoagulant rodenticide intoxication in animals显示文摘 | Ivan V Rumen B | 2008 | Turk J Vet Anim Sci2008，32，4： | 1 |
| 19 | Gold compound as ionic liquid synthesis, structure, and thermal properties of N,N'-dialkylimidazolium tetrachloroaurate salts显示文摘 | Masihul H Ivan V K Rafiq M H S | 1999 | Inorg Chem1999，38，25： | 1 |
| 20 | Identification of positive real models in subspace identification by using regularization显示文摘 | Ivan G Tony V G Johan S | 2003 | IEEE Transactions on Automatic Control2003，48，10： | 1 |
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