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| 1 | 在直肠的癌症的磁性的回声成像调查结果的临床的意义显示文摘 Staging of rectal cancer is essential to help guide clini-cians to decide upon the correct type of surgery and determine whether or not neoadjuvant therapy is indicated. Magnetic resonance imaging (MRI) is currently one of the most accurate modalities on which to base treatment decisions for patients with rectal cancer. MRI can accurately detect the mesorectal fascia, assess the invasion of the mesorectum or surrounding organs and predict the circumferential resection margin. Although nodal disease remains a difficult radiological diagnosis, new lymphographic agents and diffusion weighted imaging may allow identification of metastatic nodes by criteria other then size. In light of this, we have reviewed the literature on the accuracy of specific MRI findings for staging the local extent of primary rectal cancer. The aim of this review is to establish a correlation between MRI findings, prognosis, and available treatment options. | Charles F Bellows Bernard Jaffe Lorenzo Bacigalupo Salvatore Pucciarelli Guiseppe Gagliardi | 2011 | World Journal of Radiology2011，3，4： | 19 |
| 2 | Telomeres,telomerase and colorectal cancer显示文摘Colorectal cancer(CRC)is the third most common cancer worldwide and,despite improved treatments,is still an important cause of cancer-related deaths.CRC encompasses a complex of diseases arising from a multistep process of genetic and epigenetic events.Besides heterogeneity in the molecular and biological features of CRC,chromosomal instability is a hallmark of cancer and cancer cells may also circumvent replicative senescence and acquire the ability to sustain unlimited proliferation.Telomere/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential,and its dysfunction plays a key role in the oncogenetic process.The erosion of telomeres,mainly because of cell proliferation,may be accelerated by specific alterations in the genes involved in CRC,such as APC and MSH2.Although there is general agreement that the shortening of telomeres plays a role in the early steps of CRC carcinogenesis by promoting chromosomal instability,the prognostic role of telomere length in CRC is still under debate.The activation of telomerase reverse transcriptase(TERT),the catalytic component of the telomerase complex,allows cancer cells to grow indefinitely by maintaining the length of the telomeres,thus favouring tumour formation/progression.Several studies indicate that TERT increases with disease progression,and most studies suggest that telomerase is a useful prognostic factor.Plasma TERT mRNA may also be a promising marker for the minimally invasive monitoring of disease progression and response to therapy. | Roberta Bertorelle Enrica Rampazzo Salvatore Pucciarelli Donato Nitti Anita De Rossi | 2014 | World Journal of Gastroenterology2014，20，8： | 5 |
| 3 | PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis显示文摘 | Kathrin Ludwig Matteo Fassan Claudia Mescoli Marco Pizzi Mariangela Balistreri Laura Albertoni Salvatore Pucciarelli Marco Scarpa Giacomo Carlo Sturniolo Imerio Angriman Massimo Rugge | 2013 | Virchows Archiv2013，，1： | 3 |
| 4 | Telomere-Specific Reverse Transcriptase (hTERT) and Cell-free RNA in Plasma as Predictors of Pathologic Tumor Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy显示文摘 | Salvatore Pucciarelli Enrica Rampazzo Marta Briarava Isacco Maretto Marco Agostini Maura Digito Sonia Keppel Maria Friso Sara Lonardi Antonino Paoli Claudia Mescoli Donato Nitti Anita Rossi | 2012 | Annals of Surgical Oncology2012，，9： | 2 |
| 5 | A phase I-II study of weekly oxaliplatin,5-fluorouracil continuous infusion and preoperative radio- therapy in locally advanced rectal cancer显示文摘 | Aschele C Friso ML Pucciarelli S | 2005 | Ann Oncol2005，16，7： | 1 |
| 6 | Preoperative combined radiocherapy and chemotherapy for middle and lower rectal cancer: preliminary results显示文摘 | Pucciarelli S Friso ML Toppea P | 2000 | Ann Surg Oncol2000，7，1： | 1 |
| 7 | Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery显示文摘 | Asteria CR Gagliardi G Pucciarelli S | 2008 | Tech Coloproctol2008，12，2： | 1 |
| 8 | APC I1307K mutations and forkhead box gene (FOXO1A):another piece of an interesting correlation显示文摘 | Agostini M Bedin C Pucciarelli S | 2012 | Int J Biol Markers2012，，： | 1 |
| 9 | A Randomized Study on 1-Week Versus 4-Week Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer显示文摘 | Maria Cristina Vedovati Cecilia Becattini Fabio Rondelli Michela Boncompagni Giuseppe Camporese Ruben Balzarotti Enrico Mariani Otello Flamini Salvatore Pucciarelli Annibale Donini Giancarlo Agnelli | 2014 | Annals of Surgery2014，，： | 1 |
| 10 | Prediction of rectal lymph node metastasis by pelvic computed tomography measure- ment显示文摘 | Pomerri F Maretto I Pucciarelli S | 2009 | Eur J Surg Oncol2009，35，2： | 1 |
| 11 | Circulating cell-free DNA: A promising marker of pathologic tumor response in rectal cancer pa- tients receiving preoperative chemoradiotherapy 显示文摘 | Agostini M Pucciarelli S Enzo MV | 2011 | Ann Surg On- cot2011，18，9： | 1 |
| 12 | Characteriza- tion of the cytoplasmic chaperonin containing TCP-1 from the Antarctic fish Notothenia coriiceps 显示文摘 | Pucciarelli S Parker S K Detrich H W | 2006 | Extremophiles2006，10，6： | 1 |
| 13 | Patient-reported outcomes after neoadjuvantchemoradiotherapy for rectal cancer: a multi-center prospective observational study 显示文摘 | Pucciarelli S Del Bianco P Efficace F | 2011 | Ann Surg2011，253，1： | 1 |
| 14 | Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery显示文摘 | C. R. Asteria G. Gagliardi S. Pucciarelli G. Romano A. Infantino F. Torre F. Tonelli F. Martin C. Pulica V. Ripetti G. Diana G. Amicucci M. Carlini A. Sommariva G. Vinciguerra D. B. Poddie A. Amato R. Bassi R. Galleano E. Veronese S. Mancini G. Pescio G. | 2008 | Techniques in Coloproctology2008，，2： | 1 |
| 15 | A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation 显示文摘 | TERRAZZINO S AGOSTINI M PUCCIARELLI S | 2006 | Pharmacogenet Genomics2006，16，11： | 1 |
| 16 | Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer显示文摘 | Pomerri F Pucciarelli I Maretto M | 2011 | Surgery2011，149，1： | 1 |
| 17 | 5-Fluorouracil and weekly oxaliplatin combined with radiotherapy for locally advanced rectal cancer:surgical complications and long-term results显示文摘 | Pucciarelli S Urso E Desalvo GL | 2006 | Arch Med Res2006，37，8： | 1 |
| 18 | Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease显示文摘 | Terrin L Rampazzo E Pucciarelli S | 2008 | Clin Cancer Res2008，14，22： | 1 |
| 19 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 20 | Complete pathologic response following preoperativechemoradiation therapy for middle to lower rectal canceris not a prognostic factor for a better outcome 显示文摘 | PUCCIARELLI S TOPPAN P FRISO ML | 2004 | DisColon Rectum2004，47，11： | 1 |
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