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| 1 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 2 | Lobe-Specific Heterogeneity and Matrix Metalloproteinase Activation after Ischemia/Reperfusion Injury in Rat Livers显示文摘 | Giuseppina Palladini Andrea Ferrigno Vittoria Rizzo Eleonora Boncompagni Plinio Richelmi Isabel Freitas Stefano Perlini Mariapia Vairetti | 2012 | Toxicologic Pathology2012，，5： | 2 |
| 3 | Long -term denervation in humans causes degeneration of both contractile and excitation -contraction coupling apparatus, which is reversible by functional electrical stimulation (FES): a role for myofiber regeneration 显示文摘 | Kern H Boncompagni S Rossini K | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 4 | Microturbine and trigeneration:optimization strategies and multiple engine configuration effects显示文摘 | CAMPANARI S BONCOMPAGNI L MACCHI E | 2004 | Transactions of the ASME:Journal of Engineering for Gas Turbine and Power2004，126，： | 1 |
| 5 | Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias显示文摘 | Denegri M Avelino-Cruz J E Boncompagni S | 2012 | Circ Res2012，110，5： | 1 |
| 6 | Simultaneous analysis of classical neurolep-tics,atypical antipsychotics and their metabolites in hu-man plasma 显示文摘 | Mercolini L Grillo M Bartoletti C Boncompagni G Raggi M A | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 7 | A Randomized Study on 1-Week Versus 4-Week Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer显示文摘 | Maria Cristina Vedovati Cecilia Becattini Fabio Rondelli Michela Boncompagni Giuseppe Camporese Ruben Balzarotti Enrico Mariani Otello Flamini Salvatore Pucciarelli Annibale Donini Giancarlo Agnelli | 2014 | Annals of Surgery2014，，： | 1 |
| 8 | Clinical signiifcance of thyroid nodule calciifcation显示文摘 | Consorti F Benvenuti C Boncompagni A | | 0，，03： | 1 |
| 9 | Viral gene transferrescues arrhythmogenic phenotype and ultrastructural abnormalitiesin adult calsequestrin-null mice with inherited arrhythmias 显示文摘 | Denegri M Avelino-Cruz JE Boncompagni S | 2012 | CircRes2012，110，： | 1 |
| 10 | Machine perfusion at 20 ~C reduces preservation damage to livers from non-heart beating donors 显示文摘 | Ferrigno A Rizzo V Boncompagni E | 2011 | Cryobiology2011，62，2： | 1 |
| 11 | Progressive disorganization of the excitation-contraction coupling apparatus in aging human skeletal muscle as revealed by electron microscopy:a possible role in the decline of muscle performance显示文摘 | Boncompagni S Amelio L Ful e S | | 0，，10： | 1 |
| 12 | Long-term denervation in humans causes degeneration of both contractile and excitation-contraction coupling appara- tus, which is reversible by functional electrical stimulation (FES) : a role for myofiber regeneration? 显示文摘 | Kern H Boncompagni S Rossini K | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 13 | Egrets as moni- tors of trace-metal contamination in wetlands of Pakistan显示文摘 | Boncompagni E Muhammad A Jabeen R | 2003 | Ar- chives of Environmental Contamination and Toxicology2003，450，： | 1 |
| 14 | Characterization and temporal development of cores in a mouse model of malignant hyperthermia显示文摘 | Boncompagni S Rossi AE Micaroni M | 2009 | Proc Natl Acad Sci USA2009，106，21： | 1 |
| 15 | Egrets as monitors of tracemetal contamination in wetland of Pakistan显示文摘 | Boncompagni E Muhammad A Jabeen R Orvini E Gandini C Sanpera C Ruiz X Fasola M | | 0，，： | 1 |
| 16 | Microturbines and trigeneration: optimization strategies and multiple engine configuration effects显示文摘 | Campanari S Boncompagni L Macchi E | 2004 | Journal of Engineering for Gas Turbines and Power2004，126，1： | 1 |
| 17 | Decreased apoptosis in fatty livers submitted to subnormothermic machine perfusion re- spect to cold storage 显示文摘 | Boncompagni E Gini E Ferrigno A | 2011 | Eur J Histochem2011，55，4： | 1 |
| 18 | Machine perfusion at 20℃ reduces preservation damage to livers fron non-heart beating donors 显示文摘 | Ferrigno A Rizzo V Boncompagni E | 2011 | Cryobiology2011，62，2： | 1 |
| 19 | Clinical significance of thyroid nodule calcification显示文摘 | CONSORTI F BENVENUTI C BONCOMPAGNI A | 2003 | G Chir2003，24，3： | 1 |
| 20 | Clinical significance of thyroid nodule calcification显示文摘 | Comom F Benvenuti C Boncompagni A | 2003 | C Chir2003，24，3： | 1 |
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