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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | Perianal Crohn's disease: Is there something new?显示文摘Perianal lesions are common in patients with Crohn's disease, and display aggressive behavior in some cases. An accurate diagnosis is necessary for the optimal management of perianal lesions. Treatment of perianal Crohn's disease includes medical and/or surgical options. Recent discoveries in the pathogenesis of this disease have led to advances in medical and surgical therapy with good results. Perianal lesions in Crohn's disease remain a challenging aspect for both gastroenterologists and surgeons and lead to a greatly impaired quality of life for all patients affected by this disease. A multidisciplinary approach is mandatory to obtain the best results. | Cesare Ruffolo Marilisa Citton Marco Scarpa Imerio Angriman Marco Massani Ezio Caratozzolo Nicolò Bassi | 2011 | World Journal of Gastroenterology2011，17，15： | 3 |
| 3 | PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis显示文摘 | Kathrin Ludwig Matteo Fassan Claudia Mescoli Marco Pizzi Mariangela Balistreri Laura Albertoni Salvatore Pucciarelli Marco Scarpa Giacomo Carlo Sturniolo Imerio Angriman Massimo Rugge | 2013 | Virchows Archiv2013，，1： | 3 |
| 4 | B1a lymphocytes in the rectal mucosa of ulcerative colitis patients显示文摘AIM:To assess B1a cell expression in the rectal mucosa of ulcerative colitis (UC) patients in comparison with healthy controls.METHODS:Rectal mucosa biopsies were collected from 15 UC patients and 17 healthy controls.CD5 + B cells were analysed by three colour flow cytometry from rectal mucosal samples after mechanical disaggregation by Medimachine.Immunohistochemical analysis of B and T lymphocytes was also performed.Correlations between,on the one hand,rectal B1a cell concentrations and,on the other,erythrocyte sedimentation rate and C-reactive protein levels and clinical,endoscopic and histological disease activity indices were evaluated.RESULTS:Rectal B-lymphocyte (CD19 + /CD45 +) rate and concentration were higher in UC patients compared with those in healthy controls (47.85% ± 3.12% vs 26.10% ± 3.40%,P=0.001 and 501 ± 91 cells/mm 2 vs 117 ± 18 cells/mm 2,P < 0.001);Rectal B1a cell density (CD5 + CD19 +) was higher in UC patients than in healthy controls (85 ± 15 cells/mm 2 vs 31 ± 6.7 cells/mm 2,P=0.009).Rectal B1a cell (CD5/CD19 +) rate correlated inversely with endoscopic classification (Rs=-0.637,P < 0.05).CONCLUSION:B1a lymphocytes seem to be involved in the pathogenesis of UC,however,the role they play in its early phases and in disease activity,have yet to be defined. | Lino Polese Riccardo Boetto Giuseppe De Franchis Imerio Angriman Andrea Porzionato Lorenzo Norberto Giacomo Carlo Sturniolo Veronica Macchi Raffaele De Caro Stefano Merigliano | 2012 | World Journal of Gastroenterology2012，18，2： | 2 |
| 5 | Relevance of fecal calprotectin and lactoferrin in the postoperative management of inflammatory bowel diseases显示文摘The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease(IBD) patients' management. The postoperative setting in both Crohn's disease(CD) and ulcerative colitis(UC) patients has been less investigated although few promising results come from small, crosssectional studies. Therefore, the current post-operative management still requires endoscopy 6-12 mo after intestinal resection for CD in order to exclude endoscopic recurrence and plan the therapeutic strategy. In patients who underwent restorative proctocolectomy, endoscopy is required whenever symptoms includes the possibility of pouchitis. There is emerging evidence that fecal calprotectin and lactoferrin are useful surrogate markers of inflammation in the post-operative setting, they correlate with the presence and severity of endoscopic recurrence according to Rutgeerts' score and possibly predict the subsequent clinical recurrence and response to therapy in CD patients. Similarly, fecal markers show a good correlation with the presence of pouchitis, as confirmed by endoscopy in operated UC patients. Fecal calprotectin seems to be able to predict the short-term development of pouchitis in asymptomatic patients and to vary according to response to medical treatment. The possibility of both fecal markers to used in the routine clinical practice for monitoring IBD patients in the postoperative setting should be confirmed in multicentric clinical trial with large sample set. An algorithm that can predict the optimal use and timing of fecal markers testing, the effective need and timing of endoscopy and the cost-effectiveness of these as a strategy of care would be of great interest. | Roberta Caccaro Imerio Angriman Renata D'Incà | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 2 |
| 6 | Ovarian metastasis from colorectal cancer: prognostic value of radical oophorectomy显示文摘 | Erroi F Scarpa M Angriman I | 2007 | J Surg Oncol2007，96，2： | 1 |
| 7 | Laser photoablation of colorectal adenomas: a 12 -year experience显示文摘 | Norberto L Polese L Angriman I | 2005 | Surg Endosc2005，19，8： | 1 |
| 8 | Abdominal aortic aneurysm with coexistent horseshoe kidney显示文摘 | Frego M Bianchera G Angriman I | 2007 | Surg Today2007，37，7： | 1 |
| 9 | Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis显示文摘AIM: To focus on the role of CD40 and CD40L in their pathogenesis.METHODS: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls.RESULTS: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.CONCLUSION: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations. | Lino Polese Imerio Angriman Giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa Cesare Ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 10 | Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature显示文摘 | Cortese S Angriman M Maffeis C | 2008 | Crit Rev Food Sci Nutr2008，48，6： | 1 |
| 11 | Ovarian metastasis f-rom colorectal cancer:prognostic value of radical oophorectomy显示文摘 | Erroi F M Scarpa I Angriman | | 0，，02： | 1 |
| 12 | Diode laser treatment of Barrett's esophagus:long-term results显示文摘 | Polese L Angriman I Scarpa M | 2011 | Laser Medical Science2011，26，2： | 1 |
| 13 | Role of stapled and hand-sewn anastomoses in recurrence of Crohn' s disease 显示文摘 | Scarpa M Angriman I Barollo M | 2004 | Hepatogastroenterology2004，51，58： | 1 |
| 14 | Ruptured aneurysms of the abdominal aortic: from the First Aid to the Operating Room 显示文摘 | Frego M Bianchera G Angriman I | 2007 | Ann Ital Chir2007，78，4： | 1 |
| 15 | Ovarian metastasis from colorectal cancer:prognostic value of radical oophorectomy显示文摘 | Erroi F Scarpa M Angriman I | | 0，，02： | 1 |
| 16 | Enzymes in feces:Useful markers of chronic inflammatory bowel disease显示文摘 | Angriman I Searpa M DInca R | 2007 | Clin Chim Acta2007，381，： | 1 |
| 17 | Enzymes in feces: useful markers of chronic inflammatory bowel disease显示文摘 | Angriman I Scarpa M D'Inca R | 2007 | Clin Chim Acta2007，381，1： | 1 |
| 18 | Helicob&cter pylori &rid g&stroesoph&ge&l reflux dise&se:& cross section&l study显示文摘 | Scarp& M Angriman I Pr&ndo D et &l | | Hep&tog&stroenterology 20 10，58，： | 1 |
| 19 | Yttrium-alumi-num-garnet laser therapy of esophageal granular cell tumor显示文摘 | Norberto L Urso E Angriman I | 2002 | Surg Endosc2002，，2： | 1 |
| 20 | Ruptured aneurysms of the abdominal aorta : from the first aid to the operating room 显示文摘 | Frego M Biancheras G Angriman I | 2007 | Ann hal chir2007，78，4： | 1 |
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