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| 1 | Incidence, clinical impact and risk of bleeding during oral anticoagulation therapy显示文摘Bleeding is the most important complication of oral anticoagulation (OAC) with vitamin K-antagonists. Whilst bleeding is unavoidably related to OAC, it may have a great impact on the prognosis of treated subjects by leading to discontinuation of treatment, permanent disability or death. The yearly incidence of bleeding during OAC is 2%-5% for major bleeding, 0.5%-1% for fatal bleeding, and 0.2%-0.4% for intracranial bleeding. While OAC interruption and/or antagonism, as well as administration of coagulation factors, represent the necessary measures for the management of bleeding, proper stratification of the individual risk of bleeding prior to start OAC is of paramount importance. Several factors, including advanced age, female gender, poor control and higher intensity of OAC, associated diseases and medications, as well as genetic factors, have been proven to be associated with an increased risk of bleeding. Most of these factors have been included in the development of bleeding prediction scores, which should now be used by clinicians when prescribing and monitoring OAC. Owing to the many limitations of OAC, including a narrow therapeutic window, cumber-some management, and wide interand intra-individual variability, novel oral anticoagulants, such as factor Xa inhibitors and direct thrombin inhibitors, have been recently developed. These agents can be given in f ixed doses, have little interaction with foods and drugs, and do not require regular monitoring of anticoagulation. While the novel oral anticoagulants show promise for effective thromboprophylaxis in atrial f ibrillation and venous thromboembolism, def initive data on their safety and eff icacy are awaited. | Andrea Rubboli Cecilia Becattini Freek WA Verheugt | 2011 | World Journal of Cardiology2011，3，11： | 3 |
| 2 | To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta‐analysis显示文摘 | F. Rondelli W. Bugiantella M. C. Vedovati R. Balzarotti N. Avenia E. Mariani G. Agnelli C. Becattini | 2014 | Colorectal Dis2014，，2： | 2 |
| 3 | NMR based techniques in the hit identification and optimisation processes显示文摘 | Pellecchia M Becattini B Crowell K J | 2004 | Expert Opin Therapeutic Targets2004，8，： | 1 |
| 4 | Aspirin for pre-venting the recurrence of venous thromboembolism显示文摘 | Becattini C Agnelli G Schenone A | 2012 | N En-gl J Med2012，366，21： | 1 |
| 5 | Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid显示文摘 | Becattini B Culmsee C Leone M | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，12： | 1 |
| 6 | Thrombolysis or heparin in the treatment of pulmonary embolism 显示文摘 | AGNELLI G BECATTINI C KIRSCHSTEIN T | 2002 | Arch Intern Med2002，162，： | 1 |
| 7 | Treatment of DVT: how long is enoughand how do you predict recurrence 显示文摘 | Agnelli G Becattini C | 2008 | J Thromb Thrombolysis2008，25，1： | 1 |
| 8 | Aspirin for preventing the recurrence of venous thromboembolism 显示文摘 | Becattini C Agnelli G Schenone A | 2012 | N Engl J Med2012，366，： | 1 |
| 9 | Cardiovascular risk factors and venous thromboembolism: a meta -analysis显示文摘 | Ageno W Becattini C Brighton T | 2008 | Circulation2008，117，1： | 1 |
| 10 | Pathogenesis of venous thromboem-bolism 显示文摘 | Becattini C Agnelli G | 2002 | Curr Opin Pulm Med2002，8，5： | 1 |
| 11 | Acute pulmonary embolism显示文摘 | AGNELLI G BECATTINI C | 2010 | N EnglJ Med2010，363，3： | 1 |
| 12 | Acute pulmonary embolism 显示文摘 | Agnelli G Becattini C | 2010 | N Engl J Med2010，363，3： | 1 |
| 13 | D-dimer for risk stratifica- tion in patients with acute pulmonary embolism 显示文摘 | Becattini C Lignani A Masotti L | 2012 | J Thromb Thrombolysis2012，33，1： | 1 |
| 14 | Prognostic value of tro- ponins in acute pulmonary embolism: a meta-analysis显示文摘 | Becattini C Vedovati MC Agnelli G | 2007 | Circu- lation2007，116，4： | 1 |
| 15 | A Randomized Study on 1-Week Versus 4-Week Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer显示文摘 | Maria Cristina Vedovati Cecilia Becattini Fabio Rondelli Michela Boncompagni Giuseppe Camporese Ruben Balzarotti Enrico Mariani Otello Flamini Salvatore Pucciarelli Annibale Donini Giancarlo Agnelli | 2014 | Annals of Surgery2014，，： | 1 |
| 16 | Prognostic value of troponins in acute pul- mortarT embolism: a recta-analysis 显示文摘 | Becattini C Vedovafi MC Agnelli G | 2007 | Circulation2007，116，4： | 1 |
| 17 | Long-term Treatment of Venous Thromboembolism显示文摘 | Cecilia Becattini Giorgia Manina | 2014 | Current Vascular Pharmacology2014，，3： | 1 |
| 18 | , a meta-analysis显示文摘 | BECATTINI C VEDOVATI M C AGNELLI G Prognostic value of troponins in acute pulmonary em bolism | 2007 | Circulation2007，116，： | 1 |
| 19 | Cardiovascular risk factors and venous thromboembolism:a meta-analysis显示文摘 | Ageno W Becattini C Brighton T | 2008 | Circulation2008，117，1： | 1 |
| 20 | Prognostic value of troponins in acute pulmonary embolism: a meta-analysis 显示文摘 | Becattini C Vedovati MC Agnelli G | 2007 | Circulation2007，116，4： | 1 |
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