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| 1 | Systemic inflammation and immune response after laparotomy vs laparoscopy in patients with acute cholecystitis, complicated by peritonitis显示文摘AIM: To evaluate acute cholecystitis, complicated by peritonitis, acute phase response and immunological status in patients treated by laparoscopic or open approach. METHODS: From January 2002 to May 2012, we conducted a prospective randomized study on 45 consecutive patients (27 women, 18 men; mean age 58 years). These subjects were taken from a total of 681 patients who were hospitalised presenting similar preoperative findings: acute upper abdominal pain with tenderness, involuntary guarding under the right hypochondrium and/or in the flank; fever higher than 38 ℃, leukocytosis greater than 10 × 10 9 /L or both, and ultrasonographic evidence of calculous cholecystitis possibly complicated by peritonitis. These patients had undergone cholecystectomy for acute calculous cholecystitis,complicated by bile peritonitis. Randomly, 23 patients were assigned to laparoscopic cholecystectomy (LC), and 22 patients to open cholecystectomy (OC). Blood samples were collected from all patients before operation and at days 1, 3 and 6 after surgery. Serum bacteraemia, endotoxaemia, white blood cells (WBCs), WBC subpopulations, human leukocyte antigen-DR (HLA-DR), neutrophil elastase, interleukin-1 (IL-1) and IL-6, and C-reactive protein (CRP) were measured at 0, 30, 60, 90, 120 and 180 min, at 4, 6, 12, 24 h, and then daily (8 A.M.) until post-operative day 6.RESULTS: The two groups were comparable in the severity of peritoneal contamination as indicated by the viable bacterial count (open group = 90% of positive cultures vs laparoscopic group = 87%) and endotoxin level (open group = 33.21 ± 6.32 pg/mL vs laparoscopic group = 35.02 ± 7.23 pg/mL). Four subjects in the OC group (18.1%) and 1 subject (4.3%) in the LC group (P < 0.05) developed intra-abdominal abscess. Severe leukocytosis (range 15.8-19.6/mL) was observed only after OC but not after LC, mostly due to an increase in neutrophils (days 1 and 3, P < 0.05). This value returned to the normal range within 3-4 d after LC and 5-7 d after OC. Other WBC types and lymphocyte subpopulations showed no significant variation. On the first day after surgery, a statistically significant difference was observed in HLA-DR expression between LC (13.0 ± 5.2) and OC (6.0 ± 4.2) (P < 0.05). A statistically significant change in plasma elastase concentration was recorded post-operatively at days 1, 3, and 6 in patients from the OC group when compared to the LC group (P < 0.05). In the OC group, the serum levels of IL-1 and IL-6 began to increase considerably from the first to the sixth hour after surgery. In the LC group, the increase of serum IL-1 and IL-6 levels was delayed and the peak values were notably lower than those in the OC group. Significant differences between the groups, for these two cytokines, were observed from the second to the twenty-fourth hour (P < 0.05) after surgery. The mean values of serum CRP in the LC group on post-operative days (1 and 3) were also lower than those in the OC group (P < 0.05). Systemic concentration of endotoxin was higher in the OC group at all intra-operative sampling times, but reached significance only when the gallbladder was removed (OC group = 36.81 ± 6.4 ρg/mLvs LC group = 16.74 ± 4.1 ρg/mL, P < 0.05). One hour after surgery, microbiological analysis of blood cultures detected 7 different bacterial species after laparotomy, and 4 species after laparoscopy (P < 0.05). CONCLUSION: OC increased the incidence of bacteraemia, endotoxaemia and systemic inflammation compared with LC and caused lower transient immunological defense, leading to enhanced sepsis in the patients examined. | Federico Sista Mario Schietroma Giuseppe De Santis Antonella Mattei Emanuela Marina Cecilia Federica Piccione Sergio Leardi Francesco Carlei Gianfranco Amicucci | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 23 |
| 2 | Peritonitis from Perforated Appendicitis: Stress Response after Laparoscopic or Open Treatment显示文摘 | Schietroma Mario Piccione Federica Carlei Francesco Clementi Marco Bianchi Zuleyka de Vita Fabiola Amicucci Gianfranco | 2012 | EN2012，，5： | 2 |
| 3 | Colorectal Infraperitoneal Anastomosis: The Effects of Perioperative Supplemental Oxygen Administration on the Anastomotic Dehiscence显示文摘 | Mario Schietroma Francesco Carlei Emanuela Marina Cecilia Federica Piccione Zuleyka Bianchi Gianfranco Amicucci | 2012 | Journal of Gastrointestinal Surgery2012，，2： | 2 |
| 4 | 第三十二指肠的部分的腺癌: 案例报告和文学的评论显示文摘We focus on the diagnostic and therapeutic problemsof duodenal adenocarcinoma,reporting a case and reviewing the literature.A 65-year old man with adenocarcinoma in the third duodenal portion was successfully treated with a segmental resection of the third part of the duodenum,avoiding a duodeno-cephalo-pancreatectomy.This tumor is very rare and frequently affects the Ⅲ and Ⅳduodenal portion.A precocious diagnosis and the exact localization of this neoplasia are crucial factors in order to decide the surgical strategy.Given a non-specificity of symptoms,endoscopy with biopsy is the diagnostic gold standard.Duodeno-ceph-alo-pancreatectomy(DCP) and segmental resection of the duodenum(SRD) are the two surgical options,with overlapping morbidity(27% vs 18%) and post operative mortality(3% vs 1%).The average incidence of postoperative long-term survival is 100%,73.3% and31.6% of cases after 1,3 and 5 years from surgery,respectively.Long-term survival is made worse by two factors:the presence of metastatic lymph nodes and tumor localization in the proximal duodenum.The two surgical options are radical:DCP should be used only for proximal localizations while SRD should be chosen for distal | Federico Sista Giuseppe De Santis Antonio Giuliani Emanuela Marina Cecilia Federica Piccione Laura Lancione Sergio Leardi Gianfranco Amicucci | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 2 |
| 5 | Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma 显示文摘 | Amicucci P Gennarelli M Novelli G | 2000 | Clini Chem2000，46，2： | 1 |
| 6 | Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma 显示文摘 | Amicucci P Gennarelli M Novelli G | 2000 | Clin Chem2000，46，2： | 1 |
| 7 | Supporting evidence for using biomarkers in the diagnosis of MCI due to AD显示文摘 | Galluzzi S Geroldi C Amicucci G | 2013 | J Neurol2013，260，2： | 1 |
| 8 | Low incidence of neutralizing antibody formation to interferon α2b in uman recipients显示文摘 | Dianzani F Antonelli G Amicucci p | 1989 | Interferon RES1989，9，： | 1 |
| 9 | Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery显示文摘 | C. R. Asteria G. Gagliardi S. Pucciarelli G. Romano A. Infantino F. Torre F. Tonelli F. Martin C. Pulica V. Ripetti G. Diana G. Amicucci M. Carlini A. Sommariva G. Vinciguerra D. B. Poddie A. Amato R. Bassi R. Galleano E. Veronese S. Mancini G. Pescio G. | 2008 | Techniques in Coloproctology2008，，2： | 1 |
| 10 | The respiratory burst and electrolyte leakage induced by sulfhydryl blockers in egria densa leaves are assoceated with H2O2 production and are dependent with on Ca^2+ influx显示文摘 | MARREM T AMICUCCI E ZINGARELLI L | 1998 | Plant Physiol1998，118，： | 1 |
| 11 | Identification of ectomycorrhizal fungi of the genus Tuber 显示文摘 | Amicucci A Zambonelli A Giomaro G | 1998 | Mol Ecol1998，7，3： | 1 |
| 12 | 基于物联网的预测性维护如何削减成本显示文摘前言采用智能方式部署的连网传感器能够在影响流程或生产之前检测到故障,从而节省维护成本并避免停机。为了避免低效的维护程序和随之而来的成本,制造商和网络运营商可以使用智能传感器和数据科学原理来优化维护过程。根据这份麦肯锡发表的报告,基于物联网的预测性维护,有助于将工厂设备的维护成本降低多达40%。它还可以“通过延长机器的使用寿命,将设备停机时间减少50%,并将设备资本投资减少3%至5%”。 | Lorenzo Amicucci | 2019 | 中国集成电路2019，28，7： | 1 |
| 13 | Identification of ectomy- eorrhizal fungi of the genus tuber 显示文摘 | AMICUCCI A ZAMBONELLI A GIOMARO G | 1998 | Mol Ecol1998，7，3： | 1 |
| 14 | Gastric metastases of breast carcinoma显示文摘 | Amicucci G Sozio ML Szio A | 1999 | Am J Gastroenterol1999，94，3： | 1 |
| 15 | Hyphal and cy-toskeleton polarization in Tuber melanosporum:agenomic and ce-llular analysis显示文摘 | Amicucci A Balestrini R Kohler A Barbieri E Saltarelli R Faccio A Roberson RW BonfanteP StocchiV | 2011 | Fungal Genet Biol2011，48，6： | 1 |
| 16 | Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma显示文摘 | Amicucci P Gennarelli M Novelli G | 2000 | Clin Chern2000，46，2： | 1 |
| 17 | Prental diagnosis of myotonicdy strophy using fetal DNA obtained from maternal plasma显示文摘 | Amicucci P Gennarelli M Novelli G | 2000 | Clin Chem2000，46，： | 1 |
| 18 | Cultivation of edible eetomyeorrhizal mushrooms显示文摘 | Wang Yun Antonella Amicucci | 2003 | Trends in Biotechnology2003，21，10： | 1 |
| 19 | Cultivation of edible ectomycorrhizalmushrooms 显示文摘 | Hall IR Yun W Amicucci A | 2003 | Trends in Biotechnology2003，21，10： | 1 |
| 20 | Identification of ectomycorrhizal fungi of the genus tuber 显示文摘 | Amicucci A Zambonelli A Giomaro G | 1998 | Mol Ecol1998，7，3： | 1 |
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