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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 3 | 100%RAP的温拌再生沥青混合料的路用性能研究显示文摘沥青路面施工行业一直存在较大的节能减排的压力。一方面可以通过降低沥青混合料的拌和、摊铺温度来实现;另一方面,废旧沥青路面材料(RAP)的回收也是一个可行方案,既可减少废物的生产,同时又有利于减少资源的消耗。该文开展了一项温拌沥青配合使用RAP集料的研究:在低于常规热拌混合料工艺温度的条件下,生产含有100%RAP温拌再生沥青混合料。使用100%RAP和不同乳化沥青含量制备几种温拌再生沥青混合料(WMRA),并通过室内试验对它们的性能进行了评估,如水敏感性、劲度模量、抗疲劳性能和抗车辙性能。结果表明:这些WMRA可替代常规热拌沥青混合料用于公路路面。 | 肖庆一 张靖洁 李宁利 张萌骐 Marisa Dinis-Almeida Joo CastroGomes Cesare Sangiorgi Salah E.Zoorob Márcia Lopes Afonso | 2017 | 中外公路2017，37，3： | 6 |
| 4 | Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review显示文摘Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk patients.Pre-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse events.Several studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage time.This review was designed to provide an update on the current scientific evidence regarding PEP available in the literature. | Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo Lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
| 5 | Cardiovascular risk prediction in the elderly显示文摘Heart failure(HF)in the elderly,besides being a leading cause of mortality and morbidity,is rapidly increasing in prevalence with patients aged 65 and older accounting for more than 75%of heart failure hospitalizations.Elderly patients have historically been unrepresented in clinical HF trials and often present with multiple comorbidities,including frailty,depression,nutritional,functional and cognitive impairments.Additionally,pharmacologic challenges such as adherence to therapy,polypharmacy,altered drug pharmacokinetics and/or renal derangements make them less likely to receive guideline-directed medical therapies for HF.Recognition of these various interrelated domains is key and should prompt a multidisciplinary,holistic management approach so as to optimize prognosis in this vulnerable subset of the population. | Kartik Kumar Luis Afonso | 2019 | Journal of Geriatric Cardiology2019，16，5： | 4 |
| 6 | Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells显示文摘 | A. M. Madec R. Mallone G. Afonso E. Abou Mrad A. Mesnier A. Eljaafari C. Thivolet | 2009 | Diabetologia2009，，7： | 3 |
| 7 | Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the SWAT model显示文摘Land use and land cover(LULC)changes strongly affect local hydrology and sediment yields.The current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1)to perform an effective diagnosis of flow and sediment yield,(2)to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and(3)to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield series.The Soil and Water Assessment Tool(SWAT)model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow seasonality.Furthermore,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric tests.It was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment yield.According to trend and homogeneity tests,these sub-basins had break points in the time series of these variables.On the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and trendless.The current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water supply.Thus,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources. | Edivaldo Afonso de Oliveira Serrao Madson Tavares Silva Thomas Rocha Ferreira Lorena Conceiçao Paiva de Ataide Cleber Assis dos Santos Aline Maria Meiguins de Lima Vicente de Paulo Rodrigues da Silva Francisco de Assis Salviano de Sousa Denis Jose Cardoso Gomes | 2022 | International Journal of Sediment Research2022，37，1： | 3 |
| 8 | 用生物质谱方法研究抗肿瘤双β-咔啉与DNA及核苷酸的非共价结合显示文摘利用电喷雾傅里叶变换离子回旋共振质谱研究一系列双β-咔啉化合物与DNA的非共价结合。发现化合物1—5与5种不同序列的12-mer双链DNA均有明显的非共价结合,并且有两个β-咔啉环之间连接碳链的长度对此类化合物与双链DNA的非共价结合活性有明显影响.同时对此类化合物对于DNA非共价结合的序列选择性进行了讨论.另外还利用电喷雾离子阱质谱研究了双β-咔啉化合物2和4与4种单核苷酸的非共价结合. | 董肖椿 胥颖 Carlos AFONSO 蒋为群 Jean-Claude TABET 闻韧 | 2008 | 高等学校化学学报2008，29，8： | 3 |
| 9 | EUS visualization and direct celiac ganglia neurolysis predicts better pain relief in patients with pancreatic malignancy (with video)显示文摘 | Gil Ascunce Afonso Ribeiro Isildinha Reis Caio Rocha-Lima Danny Sleeman Jaime Merchan Joe Levi | 2011 | Gastrointestinal Endoscopy2011，，2： | 2 |
| 10 | Dexmedetomidine: Current Role in Anesthesia and Intensive Care显示文摘 | Joana Afonso Flávio Reis | 2012 | Brazilian Journal of Anesthesiology2012，，1： | 2 |
| 11 | Hepatocellular Carcinoma Is Associated With an Increased Risk of Hepatitis B Virus Recurrence After Liver Transplantation显示文摘 | Luciana C. Faria Michelle Gigou Anne M. Roque–Afonso Mylene Sebagh Bruno Roche Guillaume Fallot Teresa C.A. Ferrari Catherine Guettier Elisabeth Dussaix Denis Castaing Christian Brechot Didier Samuel | 2008 | Gastroenterology2008，，7： | 2 |
| 12 | Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease显示文摘 | Brian A. Ference Wonsuk Yoo Issa Alesh Nitin Mahajan Karolina K. Mirowska Abhishek Mewada Joel Kahn Luis Afonso Kim Allan Williams John M. Flack | 2012 | Journal of the American College of Cardiology2012，，25： | 2 |
| 13 | 激光表面熔化对Ti-30Nb-4Sn合金晶体织构、显微组织、弹性模量和硬度的影响显示文摘骨科植入物的生物相容性与其弹性模量和表面性能密切相关。本研究的目的是阐明冷轧、再结晶和表面激光熔化(LSM)对双相(α″+β)Ti-30Nb-4Sn合金显微组织和力学性能的影响。对冷轧态基体进行X射线衍射织构分析(XRD)显示有[302]α″//ND织构成分,而对再结晶态基体的分析显示有[302]α″//ND和[110]α″//ND织构成分。XRD不能直接检测出β相织构,但是通过考虑α′′相和β相之间的位向关系可成功预测出[111]β||ND织构的存在。纳米压痕测试结果表明,冷轧态基体的弹性模量(63 GPa)低于再结晶态基体(74 GPa)。根据已有文献和本文研究结果,认为这种差异是由冷变形过程中晶体缺陷的引入造成的。纳米压痕/EBSD分析表明,纳米压痕结果不受晶体取向的影响。LSM对变形合金硬度、弹性模量和晶体织构产生的变化类似于再结晶热处理产生的变化,均在表面和基体之间产生刚度梯度。 | Leonardo FANTON Nelson Batista de LIMA Emilio Rayon ENCINAS Vicente Amigo BORRAS Conrado Ramos Moreira AFONSO Joao Batista FOGAGNOLO | 2020 | Transactions of Nonferrous Metals Society of China2020，30，2： | 2 |
| 14 | Absence of Lymph Nodes in the Resected Specimen After Radical Surgery for Distal Rectal Cancer and Neoadjuvant Chemoradiation Therapy: What does it Mean?显示文摘 | Angelita Habr-Gama M.D. Ph.D. Rodrigo O. Perez M.D. Ph.D. Igor Proscurshim M.S. Viviane Rawet M.D. Ph.D. Diego D. Pereira M.S. Afonso H. S. Sousa M.D. Ph.D. Desiderio Kiss M.D. Ph.D. Ivan Cecconello M.D. Ph.D | 2008 | Diseases of the Colon & Rectum2008，，3： | 2 |
| 15 | Antioxidant, antimicrobial activities and characterization of phenolic compounds from buriti ( Mauritia flexuosa L. f.) by UPLC–ESI-MS/MS显示文摘 | Hector H.F. Koolen Felipe M.A. da Silva Fábio C. Gozzo Antonia Q.L. de Souza Afonso D.L. de Souza | 2013 | Food Research International2013，，2： | 2 |
| 16 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 17 | 青少年乒乓运动员的焦虑和运动成绩关系(英文)显示文摘多维焦虑理论认为认知和躯体焦虑对运动成绩会产生不同的影响。根据这个理论,运动员在赛前具有较高的认知焦虑水平或躯体焦虑水平出现极端值(过高或过低)或自信心较低时,他们将取得较差的运动成绩。先前的研究还认为焦虑与运动成绩间的关系还取决于所要完成动作的特点。不同的运动技能有各自最佳的焦虑水平。总的来说,焦虑水平较高有利于完成体力消耗较大的运动项目。而焦虑水平较低时,则有利于完成精确类项目。就乒乓球项目而言,它既需要体力又需要精确性,因此,本研究调查分析了乒乓球运动员赛前焦虑水平与运动成绩间的关系。研究对象:36 名青少年乒乓球运动员,男、女运动员各18 名,平均年龄为12.28±0.74岁。研究方法:采用运动竞赛状态焦虑量表(CSAI-2C)。让运动员在参加地区赛第一场比赛的赛前30分填写问卷。研究结果:认知状态焦虑水平不能用来预测运动员的成绩。获胜运动员和失利运动员赛前的躯体状态焦虑和自信心没有差异。这表明本研究没有支持多维焦虑理论的假设,或许是乒乓球运动的特点和运动员的个体差异比运动员的焦虑水平对运动成绩的影响更大。因此,如果运动员的个人特点与他们的技术风格相适应,不同焦虑水平的运动员都可能取得好成绩。 | Cristina Akiko Iizuka Welber Marinovic Afonso Antonio Machado Luiz Henrique Porto Vilani | 2005 | 体育科研2005，26，3： | 2 |
| 18 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 19 | Recovery of valuable elements from spent Li-batteries显示文摘 | Paulino J F Busnardo N G Afonso J C | 2008 | Journal of Hazardous Materials2008，150，： | 1 |
| 20 | Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam显示文摘 | Nabors GS Afonso LC Farrell JP | 1995 | Proc Natl Acad Sci U S A1995，92，： | 1 |
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