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| 1 | 集合系统CT三维重建精准指导经皮肾镜手术目标肾盏选择和穿刺的临床研究显示文摘目的探讨集合系统CT三维重建帮助经皮肾镜手术(PCNL)精准进行目标肾盏选择和目标肾盏穿刺的可行性和安全性。方法肾结石PCNL患者196例,均行术前腹部泌尿系平片(KUB)、静脉肾盂造影(IVU)、CT平扫和增强扫描,分别获取肾结石、集合系统及肾脏周围器官的CT三维影像,在集合系统三维重建后面观影像上确定最佳PCNL目标肾盏,将确定的目标肾盏通过影像转化技术标识在IVU影像上,C臂机引导下穿刺该目标肾盏建立手术通道。结果所有PCNL手术均按术前的规划实现了精准穿刺目标肾盏建立手术通道,196例患者术中、术后无严重出血、邻近器官损伤等并发症,均未输血。鹿角形肾结石手术无石率为88%,肾盂肾盏结石94.1%。结论通过对影像的技术转化,将CT集合系统三维重建确定的目标肾盏准确标识在IVU影像上,指导PCNL术中对目标肾盏进行精准选择和精准穿刺,建立更加安全的手术通道,最大程度降低PCNL出血和器官损伤等并发症。 | 李炯明 王光 刘建和 姜永明 张劲松 方克伟 石鑫 Prashant Mishra | 2017 | 临床外科杂志2017，25，2： | 12 |
| 2 | Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice显示文摘Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. | Deepti SRIVASTAVA Md SHAMIM Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH | 2017 | Rice science2017，24，6： | 8 |
| 3 | 640层CT动态评估压力性尿失禁及盆腔脏器脱垂的研究显示文摘目的:女性压力性尿失禁(FSUI)和盆腔脏器脱垂(POP)是中老年女性常见的问题,本研究为了探讨640层螺旋CT(640-MSCT)诊断FSUI和POP的可能性。方法:本研究招募了62例FSUI患者(SUI组)、96例POP患者(POP组)和50例健康女性志愿者(对照组)进行640-MSCT骨盆扫描。所有志愿者和患者在排尿前、排尿时和排尿后进行扫描,然后用640-MSCT扫描图像重建3D和4D图像,由2名放射科医师进行复查。通过观察这些图像,我们测量并比较了每个时期的耻骨尾骨线(PCL)、H线、M线、PCL到膀胱颈(PCL-BN)、PCL到宫颈(PCL-c)、尿道倾斜角(UIA)和膀胱尿道后角(PUVA)。结果:本研究比较了志愿者和患者(SUI患者和POP患者)的结果。实验组和对照组中的生育状况和BMI比较差异无统计学意义(P>0.05)。结果表明,各组H线、M线排尿前、排尿及排尿后比较差异均有统计学(P<0.01,P<0.05)。各组排尿时PCL-BN和PCL-C均降低。SUI组和POP组中部分受试者排尿前PCL-BN在PCL线以下,排尿时更加明显。排尿时,POP组中PCL-C明显下降。对照组的UIA和PUVA对比SUI组和POP组在排尿时差异有统计学意义(P<0.05)。结论:采用640-MSCT的3D和4DCT图像进行SUI和POP诊断是一种敏感且具体可行的方法。 | 赵永先 杨博伟 苏云杉 Prashant Mishra 陈韬 毛崇文 刘建和 张海燕 郭海翔 王家平 刘攀 方克伟 | 2020 | 临床泌尿外科杂志2020，，5： | 7 |
| 4 | Assessment of performance,combustion and emissions characteristics of methanol-diesel dual-fuel compression ignition engine:A review显示文摘The energy security concern and rapidly diminishing fossil fuel resources demand the development of renewable and economically attractive fuel for reciprocating engines.Methanol is a promising renewable alternative fuel.Numerous studies have been carried out to explore the various aspects of the utilization of methanol in compression ignition(CI)engine.This review paper presents a detailed analysis of the effect of methanol on performance,combustion,and emission(NOx,CO,HC,and soot)characteristics of conventional CI-engine along with dual-fuel combustion mode.This study focuses on methanol utilization in dual-fuel mode,which is an advanced engine combustion mode.First,methanol production and solubility issues of methanol in diesel are briefly discussed.This study discusses the soot and nano-particle emission from the methanol fueled CI-engine,which is one of the main concerns in the current emission legislation.It was found that the utilization of methanol in CI-engine has the potential to improve the performance and simultaneously with a significant reduction in NOx,CO,soot,and nano-particle emissions in comparison to neat diesel operation.However,unburnt HC emission reduces for methanol-diesel blended fuel operation whereas HC emissions are higher for methanoldiesel dual-fuel operation. | Mohit Raj Saxena Rakesh Kumar Maurya Prashant Mishra | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 4 |
| 5 | 554例部分无管化mPCNL临床分析显示文摘目的总结部分无管化mPCNL经验.方法回顾性分析2010年1月至2016年12月多中心部分无管化mPCNL手术经验.7 a间共完成1 320例mPCNL手术,其中部分无管化mPCNL554例,标准化mPCNL766例.除外手术时间大于2 h及各种原因被迫中止手术的85例,共681例标准化mPCNL与部分无管化mPCNL进行比较.结果随着部分无管化手术指征逐渐放宽,部分无管化手术率增加,并发症并无增加,2016年部分无管化mPCNL率达84%.与标准化mPCNL比较,二者手术净石率、平均血红蛋白下降、输血率、术后发热率无显著差异.术后止痛剂应用率、术后住院天数有显著差异,分别为5%:21%(P=0.001)和2.5:4.5 d(P=0.001).术后出血相关并发症发生率无管化与标准组分别为1.1%和2.5%,无显著性差异.部分无管化组发生1例尿外渗,1例胸膜损伤出血,分别予肾周引流、抗生素治疗及开放探查、胸腔引流后顺利出院.结论与标准mPCNL相比,部分无管化mPCNL明显增加患者术后的舒适性,缩短住院时间,术后相关并发症无增加,是安全可行的手术方式. | 姜永明 郭海翔 Mishra Prashant 陈戬 李炯明 王剑松 | 2018 | 昆明医科大学学报2018，39，5： | 3 |
| 6 | 压力性尿失禁大鼠中环氧合酶2表达的变化及意义显示文摘目的压力性尿失禁(SUI)的发病机制研究较少。文中旨在检测环氧合酶2(COX?2)在SUI大鼠模型中的尿道、阴道、尿道平滑肌中的表达变化。方法健康雌性未育SD大鼠60只,雄性SD大鼠15只,合拢自然妊娠,取分娩后雌性大鼠分别行扩张阴道(单纯扩张组)、扩张阴道+切除卵巢(扩张+切除组)建立SUI大鼠模型,另使用正常妊娠分娩后大鼠为对照组,每组6只。通过喷嚏实验及尿动力学检查最大膀胱容量(MBC)和腹压漏尿点压(ALPP),荧光定量PCR、Western blot检测COX?2 mRNA及蛋白水平的表达,免疫组化检测COX?2在尿道、阴道、尿道平滑肌的表达。结果扩张+切除组、单纯扩张组ALPP较对照组明显下降,扩张+切除组较单纯扩张组明显下降(P<0.05)。单纯扩张组、扩张+切除组COX?2mRNA表达量[(1.40±0.07)、(1.75±0.10)]、蛋白的相对表达量[(1.64±0.05)、(1.95±0.08)]较对照组[(1.00±0.16)、(0.77±0.26)]均明显升高(P<0.001);扩张+切除组较单纯扩张组明显升高(P<0.05)。免疫组化结果显示,对照组、单纯扩张组、扩张+切除组阴道组织中COX2的染色强度表达积分依次为0.50±0.54、5.55±0.54、9.33±0.81,组间两两比较差异有统计学意义(P<0.05);尿道平滑肌组织中染色强度表达依次为0.66±0.51、5.33±0.51、8.50±0.54,组间两两比较差异有统计学差异(P<0.05)。结论切除卵巢后的雌激素下降可致COX?2表达的升高,COX?2与SUI的发病机制相关。 | 李江 杨智明 柯建 Prashant Mishra 罗伟 刘上 刘建和 袁志伟 孙浩 杨昭庆 方克伟 | 2019 | 医学研究生学报2019，32，2： | 3 |
| 7 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 8 | Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits显示文摘 | Bhanu Prakash Priyanka Singh Prashant Kumar Mishra N.K. Dubey | 2011 | International Journal of Food Microbiology2011，，1： | 1 |
| 9 | Development of a PCR-based assay for rapid and reliable identification of pathogenic Fusaria 显示文摘 | Prashant K Mishra R T V Culham F L | 2003 | FEMS Microbiology Letters2003，218，2： | 1 |
| 10 | Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation显示文摘 | Prashant Mishra Valerio Carelli Giovanni Manfredi David C. Chan | 2014 | Cell Metabolism2014，，5： | 1 |
| 11 | Dynamic Scaffolding in a G Protein-Coupled Signaling System显示文摘 | Prashant Mishra Michael Socolich Mark A. Wall Jennifer Graves ZiFen Wang Rama Ranganathan | 2007 | Cell2007，，1： | 1 |
| 12 | Multiple sclerosis: an overview 显示文摘 | Arin Bhattacharya Rahul Mishra Prashant Tiwari | 2012 | Asian Pacific Journal of Tropical Bi- omedicine2012，2，3： | 1 |
| 13 | Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits显示文摘 | Bhanu Prakash Priyanka Singh Prashant Kumar Mishra N.K. Dubey | 2011 | International Journal of Food Microbiology2011，，1： | 1 |
| 14 | Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology显示文摘Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care. | Rashmi Sahu Prashant Kumar Gupta Amit Mishra Awanish Kumar | 2023 | Chinese Journal of Integrative Medicine2023，29，5： | 0 |
| 15 | 腹腔镜和机器人辅助回肠代输尿管术在临床应用中的可行性和治疗效果(英文)显示文摘回肠代输尿管术是治疗患者长段输尿管狭窄的恰当方式.微创手术技术已被证明和开放手术具有相同的安全性,且在减少手术创伤、出血和术后康复周期方面明显优于开放手术.为了研究腹腔镜下回肠代输尿管术的可行性和临床疗效,对相关文献中该手术方案的手术指征、禁忌症、手术方法和术后结果进行了综述,并结合昆明医科大学第二附属医院对该手术的实践经验进行综合分析.共有20例腹腔镜下回肠代输尿管术报道纳入综述,其手术时间在195~480 min之间,出血量在50~375 mL之间;共有7例机器人辅助的回肠代输尿管术报道纳入综述,其手术时长在320~720 min之间,出血量少于10~100 mL.该手术的并发症包括腹腔内尿瘘、小肠梗阻、吻合口瘘、暂时性氮质血症和泌尿系感染等.术后所有患者的肾功能都得到不同程度恢复.综上,腹腔镜或机器人辅助回肠代输尿管术是治疗长段输尿管狭窄的一种可行且有效的手术方案,尽管其疗效和传统开放手术相当,但腹腔镜和机器人辅助方法因其微创特点仍具有相对优势,它们均可有效降低手术创伤、术中出血量、术后并发症、手术瘢痕形成和术后康复时间.由于现有报道的病例数量有限,故还需对回肠代输尿管的微创手术方案进行更多和长期的研究,以便建立和完善该术式的标准手术步骤和手术技巧. | Mishra Prashant 李炯明 | 2018 | 昆明医科大学学报2018，39，3： | 0 |
| 16 | A new species of Scytonema isolated from Bilaspur, Chhattisgarh, India显示文摘从 Bilaspur 的新鲜的水身体孤立的细丝状的 cyanobacterium (种类 10C-PS ) , Chhattisgarh,印度正在被描述为 polyphyletic 类 Scytonema 的新种类。Phenotypic,分子、种系发生的描述被执行,联合结果作为新种验证了种类。细丝,在整个毛状体的长度的显然粗糙的鞘的存在,在植物的房间的形状和尺寸的差别,和种类不同于的提供的可靠词法信号密切相关的种类放松的 heterocytes 的小心的观察。当定序的 rbcl 和 psbA 与 Scytonema hofmanni PCC 7110 和 Nostoc sp 显示出 95% 和 92% 类似时, 16S rRNA 基因定序与 Scytonema hofmanni PCC 7110 显示出 96.89% 顺序类似。PCC 7524 分别地当 nifD 基因顺序类似被发现与 Scytonema hofmanni PCC 7110 是 96% 时。PC-IGS 区域被定序并且并置显示的 cpcB, IGS 和 cpcA 区域有 Scytonema sp 的 97% 最靠近的类似。PCC 7110 和 Scytonema bohnerii Ind24。随后的种系发生的分析给了在所有分子的标记的情况下的不同聚类的一个强壮的模式。phenotypic,基因、种系发生的观察决定性地证明种类 10C-PS 是在类 Scytonema 的新种,名字求婚了是 Scytonema bilaspurensis。 | Prashant Singh Robin Anigo Minj Kikku Kunui Zaid Muneef Shaikh Archana Suradkar Yogesh S Shouche Arun Kumar Mishra Satya Shila Singh | 2016 | Journal of Systematics and Evolution2016，54，5： | 0 |
| 17 | Atropine eye-drop-induced acute delirium:a case report显示文摘Atropine is an anticholinergic drug which is used in both parental and topical routes.Topical eye-drops of atropine sulfate are used as mydriatic and cycloplegics.Parental atropine-induced delirium is well known but topical atropine eye-drop-induced delirium cases are very limited in literature.In this case report,an elderly man underwent cataract surgery and developed delirium after the use of 1%atropine sulfate eye-drops as prescribed.This case supports the notion that even atropine eye-drops can cause delirium in patients at therapeutic doses in elderly. | Prashant Maravi Dheerendra Kumar Mishra Amrendra Singh Vijay Niranjan | 2020 | General Psychiatry2020，33，3： | 0 |
| 18 | Advanced microemulsion synthesis and characterization of wollastonite (CaSiO3)fpolystyrene one-dimensional nanorods with core-shell structures显示文摘 | Aniruddha Chatterjee Prashant Khobragade, Satyendra Mishra Jitendra Naik | 2017 | Particuology2017，15，1： | 0 |
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