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| 1 | Current trends in laparoscopic groin hernia repair: A review显示文摘Hernia is a common problem of the modern world with its incidence more in developing countries. Inguinal hernia is the most common groin hernia repaired worldwide. With advancement in technology operative techniques of repair have also evolved. A Pub Med and COCHRANE database search was accomplished in this regard to establish the current status of laparoscopic inguinal hernia repair in view of recent published literature. Published literature support that laparoscopic hernia repair is best suited for recurrent and bilateral inguinal hernia although it may be offered for primary inguinal hernia if expertise is available. | Harvinder Singh Pahwa Awanish Kumar Prerit Agarwal Akshay Anand Agarwal | 2015 | World Journal of Clinical Cases2015，3，9： | 12 |
| 2 | Urinary Bladder Paraganglioma—A Case Series with Proposed Treating Algorithm Based on Our Experience and Review of Literature显示文摘 | Harvinder S. Pahwa Awanish Kumar Rohit Srivastava Sanjeev Misra Madhu Mati Goel | 2013 | Indian Journal of Surgical Oncology2013，，： | 1 |
| 3 | Antibiotic resistome of Salmonella typhi:molecular determinants for the emergence of drug resistance显示文摘Resistome is a cluster of microbial genes encoding proteins with necessary functions to resist the action of antibiotics.Resistome governs essential and separate biological functions to develop resistance against antibiotics.The widespread clinical and nonclinical uses of antibiotics over the years have combined to select antibiotic-resistant determinants and develop resistome in bacteria.At present,the emergence of drug resistance because of resistome is a significant problem faced by clinicians for the treatment of Salmonella infection.Antibiotic resistome is a dynamic and ever-expanding component in Salmonella.The foundation of resistome in Salmonella is laid long before;therefore,the antibiotic resistome of Salmonella is reviewed,discussed,and summarized.We have searched the literature using PubMed,MEDLINE,and Google Scholar with related key terms(resistome,Salmonella,antibiotics,drug resistance)and prepared this review.In this review,we summarize the status of resistance against antibiotics in S.typhi,highlight the seminal work in the resistome of S.typhi and the genes involved in the antibiotic resistance,and discuss the various methods to identify S.typhi resistome for the proactive identification of this infection and quick diagnosis of the disease. | Awanish Kumar Anil Kumar | 2021 | Frontiers of Medicine2021，15，5： | 1 |
| 4 | Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis显示文摘 | Nasib Singh Awanish Kumar Prasoon Gupta | 2008 | Parasitol Res2008，，56： | 1 |
| 5 | Improved Case Based Reasoning(ICBR) Tool显示文摘 | Mythili Thirugnanam Bivash Kumar Awanish Kumar Gupta | 2012 | International Journal of Advanced Research in Computer Science and Software Engineering2012，2，4： | 1 |
| 6 | Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology显示文摘Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care. | Rashmi Sahu Prashant Kumar Gupta Amit Mishra Awanish Kumar | 2023 | Chinese Journal of Integrative Medicine2023，29，5： | 0 |
| 7 | Inhibitory Interaction and Pharmacological Analyses of Berries Phenolics Against Listeria monocytogenes Virulent Protein Internalin B显示文摘Background: Traditional plants, their parts, and phytochemicals obtained from them are beneficial for human beings. They are used as potent antimicrobials, but very little research is conducted on the use of traditional medicine against food-borne infection. Different berry plants are rich in phenolic compounds and conventionally known to have many properties such as antioxidants, anti-carcinogenic, anti-inflammatory, anti-bacterial, and anti-diabetics. However, only limited polyphenols are known for their antilisterial effect. The present study aimed to explore the antimicrobial efficacy of phenolic compounds of berries for the treatment of food-borne infection caused by the bacteria Listeria monocytogenes. Materials and Methods: Molecular docking studies employing the Swiss DOCK server were performed to evaluate the antimicrobial activity of phenolic compounds obtained from different varieties of berries. Internalin B(Inl B), a virulence protein of L. monocytogenes was selected as a target. The absorption, distribution, metabolism, excretion, and toxicity profiling of each test ligand was done through the Swiss ADME tool. Results: Among all the test ligands, p-coumaric acid, epicatechins, chlorogenic acid, and quercetin showed better binding efficiency with the target protein Inl B. The binding energy obtained for quercetin, p-coumaric acid, chlorogenic acid, and epicatechins was-8.93,-8.23,-8.18,-7.58, kcal/mol, respectively. Quercetin and p-coumaric acid were forming 4 H-bonds, whereas chlorogenic acid and epicatechins were forming 3-H bonds inside the binding pocket. Conclusion: In a nutshell, analyses indicated that identified ligands have the potential to block the virulent protein Inl B of L. monocytogenes and help combat Listeria infection. These phenolic compounds could be a substitute for synthetic antimicrobials and can be used in food preservation and combat food-borne diseases. However, future in-depth in vitro and in vivo analysis is needed to get more information on these four phenolic ligands of berries. | Abhishek Kumar Archana Vimal Awanish Kumar | 2023 | World Journal of Traditional Chinese Medicine2023，9，1： | 0 |
| 8 | Identification of SARS-CoV-2 Spike Protein Inhibitors from Urtica dioica to Develop Herbal-Based Therapeutics Against COVID-19显示文摘Objective: The high transmission rate and mutations of SARS-Co V-2 have made it a global pandemic, and the shortage of any effective clinical treatment has created such a commotion. There are some synthetic antiviral drugs, such as remdesivir and lopinavir that are being repurposed to treat SARS-Co V-2, but all of these demonstrate extreme side effects in humans. Hence, promoting herbal-based drug development has become crucial as they are cost-effective and have lesser or no side effects. Urtica dioica is abundant in the Himalayan region and the compounds present in it have shown significant antiviral and anti-SARS activity. Therefore, molecular docking studies were performed to identify SARS-Co V-2 spike protein inhibitors from U. dioica to combat the COVID-19 disease. Materials and Methods: Compounds from U. dioica were screened using the bioinformatic approach, and subsequently, these compounds were docked with the S1 subunit of the COVID-19 spike protein(PDB ID: 6YOR). Molecular docking was carried out using the Py Rx software(0.8 version) and further examined by employing the Discovery Studio Visualizer. Results: About all the selected compounds showed significant binding energy(e.g., beta-sitosterol:-10.3 kcal/mol) in contrast to the control chloroquine phosphate. This binding was observed with the spike protein residues that were common in the old strain and the more contagious newly modified B.1.1.7 strain of SARS-Co V-2. Conclusions: Thus, our study can be used in effective drug development against SARS-Co V-2 and its mutant strains also. | Shobha Upreti Jyoti Sankar Prusty Awanish Kumar Mukesh Samant | 2023 | World Journal of Traditional Chinese Medicine2023，9，1： | 0 |
| 9 | Biomonitoring of endosulfan toxicity in human显示文摘Chemicals are comprehensively used worldwide to control herbs,weeds,pests,and other competing agents with various growing crops.The consumption of crops grown with these chemicals(even in small quantities)can upshot into accumulation in the human body.People can accidentally inhale these hazardous chemicals if they are in an area where they were applied.These chemicals can be ingested in a human with contaminated food and drinks.Ultimately it causes various adverse effects(chronic toxicity,teratogenic,mutagenic,carcinogenic effect,reproductive,and organ toxicity)on human health.Among the pool of these chemicals used as pesticides in the environment,exposure of endosulfan to humans has a potential health risk throughout the globe.The poisoning of endosulfan is reported frequently in society,therefore,this article highlights the toxicological and other harmful properties of endosulfan to humans and emphasized its essential biomonitoring.Its quick monitoring and effective hazard evaluation are possible with multiomics technologies and some other analytical approaches.This review summarizes the introduction and mechanism of action of endosulfan along with some other toxic chemicals used in the agriculture work,the toxicity of endosulfan in human/environment,and importantly its biomonitoring(detection of chemicals and their metabolites in a biological sample)in human because biomonitoring is often considered as the most preferred method.Biomonitoring could be easily done in human samples(blood,hair,milk,and urine)with a multi-omics approach,which is a quick,reliable,and state-of-the-art technique. | SANTOSH KUMAR KARN ADITYA UPADHYAY AWANISH KUMAR | 2022 | BIOCELL2022，46，7： | 0 |
| 10 | Promising Antiviral Molecules from Ayurvedic Herbs and Spices against COVID-19显示文摘COVID-19 is caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and smashed our society severely.Many efforts/measures have been taken worldwide to control coronavirus disease 2019(COVID-19)but it is spreading ceaselessly across the globe.Interestingly,Chinese medicine was used to treat COVID-19 and they found better recovery results.This has also drawn the attention of the scientific community to Ayurveda where traditional knowledge of this domain can be explored for finding COVID-19 a cure or prevention. | Mariappan Rajan Prashant Gupta Awanish Kumar | 2021 | Chinese Journal of Integrative Medicine2021，27，4： | 0 |
| 11 | Pharmacological, Ethnomedicinal, and Evidence-Based Comparative Review of Moringa oleifera Lam.(Shigru) and Its Potential Role in the Management of Malnutrition in Tribal Regions of India, Especially Chhattisgarh显示文摘Moringa oleifera Lam.(Shigru)(Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac,liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya(nourishing) as well as Medohara(antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry,botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books(Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic,anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry,pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities,clinical efficacy, and safety. | Kishor Sonewane Sharda Swaroop Chouhan Mariappan Rajan Nagendra Singh Chauhan Om Prakash Rout Awanish Kumar Gyanendra Singh Baghel Prashant Kumar Gupta | 2022 | World Journal of Traditional Chinese Medicine2022，8，3： | 0 |
| 12 | Frequently Used Allopathic and Traditional Medicine for COVID-19 Treatment and Feasibility of Their Integration显示文摘To date,no satisfactory treatment for COVID-19 is available.This review reported few recent updates regarding the drugs(allopathy/traditional medicines)used for the treatment of COVID-19 concerning clinical studies.Content of the article spotlight the contribution of allopathic and Ayurvedic drugs to the scientific basis for utilization as a potential therapy against COVID-19 infection and provide new insights on the integration of allopathy and traditional medicine.It advocated the combination of these two systems of treatment will ascertain their integrations,and there would be a good possibility and scope for developing a model of integration in the management of COVID-19.Provided discussion may help researchers,physicians,and healthcare policymakers to encourage for effective and integrated use of allopathic and Ayurvedic medicines to control the COVID-19 pandemic more effectively. | Aditya Upadhayay Gopal Patel Dharm Pal Awanish Kumar | 2022 | Chinese Journal of Integrative Medicine2022，28，11： | 0 |
| 13 | Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates显示文摘Persistent gastritis induced by Helicobacter pylori(H.pylori)is the strongest known risk factor for gastric cancer(GC).H.pylori is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that H.pylori infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression. | Budhadev Baral Dharmendra Kashyap Nidhi Varshney Tarun Prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem Chandra Jha | 2024 | Genes & Diseases2024，11，1： | 0 |
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