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| 1 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 2 | Impact of friction stir welding on recrystallization of oxide dispersion strengthened ferritic steel显示文摘Oxide dispersion strengthened(ODS) steels can be used as the structural materials in the future fusion reactors and the fuel cladding materials in the advanced fission reactors. However, the weldability of ODS steels is a severe problem. In the present study, defect-free joints of the 15Cr-ODS ferritic steel were achieved by friction stir welding at different rotation speeds. The recrystallization, hardness and tensile properties are highly related with the rotation speed of the stir tool. The higher rotation speed results in coarser grains in the top SZ, while the grain size exhibits more complicated relation with the rotation speed in the SZ center. The joint welded at 250 rpm exhibits a maximum tensile strength of 974 MPa that reaches about 84% of that of the base metal. | Wentuo Han Pingping Liu Xiaoou Yi Qian Zhan Farong Wan Kiyohiro Yabuuchi Hisashi Serizawa Akihiko Kimura | 2018 | Journal of Materials Science & Technology2018，34，1： | 4 |
| 3 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 4 | Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT显示文摘Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation.FPC included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance.Subsequently,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT scan.Functional parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were analyzed.Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT. | Yuming Zheng Chaoling Jin Huijuan Cui Haojie Dai Jue Yan Pingping Han Bailing Hsu | 2020 | The Journal of Biomedical Research2020，34，4： | 2 |
| 5 | Au-catalysed free-standing wurtzite structured InAs nanosheets grown by molecular beam epitaxy显示文摘In this study,we report the growth of free-standing InAs nanosheets using Au catalysts in molecular beam epitaxy.Detailed structural characterizations suggest that wurtzite structured InAs nanosheets,with features of extensive{1120}surfaces,grown along the<1102>direction and adopted{0001}nanosheet/catalyst interfaces,are initiated from wurtzite structured[0001]nanowires as the inclined epitaxial growth due to relatively higher In concentrations in Au catalysts,and grown from these inclined nanostructures through catalyst-induced axial growth and their enhanced lateral growth under the high growth temperature.Based on the facts that the nanosheets contain large low energy{1120}surfaces and{0001}nanosheet/catalyst interfaces,the growth of our nanosheets is a thermodynamically driven process.This study provides new insights into fabricating free-standing Ⅲ-Ⅴ nanosheets for their applications in future nanoscale devices. | Qiang Sun Han Gao Xiaomei Yao Kun Zheng Pingping Chen Wei Lu Jin Zou | 2019 | Nano Research2019，12，11： | 2 |
| 6 | Facilitation of cascade biocatalysis by artificial multi-enzyme complexes——A review显示文摘Multi-enzyme complexes are the results of natural evolution to facilitate cascade biocatalysis.Through enzyme colocalization within a complex,the transfer efficiency of reaction intermediates between adjacent cascade enzymes can be promoted,resulting in enhanced overall reaction efficiency.Inspired by nature,a variety of approaches have been developed for the assembly of artificial multi-enzyme complexes with different spatial organizations,aiming at improving the catalytic efficiency of enzyme cascade.A recent trend of this research area is the creation of enzyme complexes with a controllable spatial organization which helps with the mechanistic studies and bears the potential to further increase metabolic productivity.In this review,we summarize versatile strategies for the assembly of artificial multi-enzyme complexes,followed by an inspection of the mechanistic studies of artificial multi-enzyme complexes for their enhancement of catalytic efficiency.Furthermore,we provide some highlighted in vivo,ex vivo,and in vitro examples that demonstrate the ability of artificial multi-enzyme complexes for enhancing the overall production efficiency of value-added compounds.Recent research progress has revealed the great biotechnological potential of artificial multi-enzyme complexes as a powerful tool for biomanufacturing. | Xinlei Wei Pingping Han Chun You | 2020 | Chinese Journal of Chemical Engineering2020，28，11： | 2 |
| 7 | Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway显示文摘 | Huanlong Liu Xueyan Chen Yu Han Chaoyi Li Pingping Chen Yongjian Zhang Zhenhua Pan | 2013 | Biomedicine & Pharmacotherapy2013，，： | 2 |
| 8 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 9 | Poly(benzobisoxazole divinylene):synthesis,photophysical properties,and electron paramagnetic resonance studies显示文摘 | Guo Peiying Wang Shanfeng Wu Pingping Han Zhewen | 2004 | Polymer2004，45，6： | 1 |
| 10 | Supramolecular regulation of photophysical properties and electron paramagnetic resonance studies of novel rod-coil ordered copolymers based on poly (p-phenylene benzobisoxazole)显示文摘 | Wang Shanfeng Guo Peiying Wu Pingping Han Zhewen | 2004 | Macromolecules2004，37，10： | 1 |
| 11 | Effect of heat treatment on the structure and properties of poly(2,6-benzothiazole) (ABPBT) and poly (2,5-benzoxazole) (ABPBO)显示文摘 | Wang Shan-feng Bao Gao-bin Lu Zhi-bao Wu Pingping Han Zhe-wen | 2000 | Journal of Materials Science2000，35，： | 1 |
| 12 | Prepatation and surface properties of fluorine-containing diblock copolymers显示文摘 | Wu Pingping Han Zhewen | 2002 | Polymer2002，43，： | 1 |
| 13 | Electron paramagnetic resonance of poly(benzazole)s and conducting properties of N^+- implanted poly (benzazole) s 显示文摘 | Wang Shanfeng Wu Pingping Han Zhewen | 2001 | Polymer2001，42，1： | 1 |
| 14 | D-Galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress显示文摘 | Xu Cui Luning Wang Pingping Zuo Zhitao Han Zhengyu Fang Wenbin Li Jiankang Liu | 2004 | Biogerontology2004，，5： | 1 |
| 15 | A novel waste water scale-derived solid base catalyst for biodiesel production显示文摘 | Pingbo Zhang Qiuju Han Mingming Fan Pingping Jiang | 2014 | Fuel2014，，： | 1 |
| 16 | D-Galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress显示文摘 | Xu Cui Luning Wang Pingping Zuo Zhitao Han Zhengyu Fang Wenbin Li Jiankang Liu | 2004 | Biogerontology2004，，5： | 1 |
| 17 | An in vitro synthetic biology platform for emerging industrial biomanufacturing:Bottom-up pathway design显示文摘Although most in vitro(cell-free)synthetic biology projects are usually used for the purposes of fundamental research or the formation of high-value products,in vitro synthetic biology platform,which can implement complicated biochemical reactions by the in vitro assembly of numerous enzymes and coenzymes,has been proposed for low-cost biomanufacturing of bioenergy,food,biochemicals,and nutraceuticals.In addition to the most important advantage-high product yield,in vitro synthetic biology platform features several other biomanufacturing advantages,such as fast reaction rate,easy product separation,open process control,broad reaction condition,tolerance to toxic substrates or products,and so on.In this article,we present the basic bottom-up design principles of in vitro synthetic pathway from basic building blocks-BioBricks(thermoenzymes and/or immobilized enzymes)to building modules(e.g.,enzyme complexes or multiple enzymes as a module)with specific functions.With development in thermostable building blocks-BioBricks and modules,the in vitro synthetic biology platform would open a new biomanufacturing age for the cost-competitive production of biocommodities. | Ting Shi Pingping Han Chun You Yi-Heng P.Job Zhang | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 1 |
| 18 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 19 | The Combination of Mycophenolate Mofetil with Corticosteroids Induces Remission of Henoch-Schonlein Purpura Nephritis显示文摘 | Ren Pingping Han Fei Chen Liangliang Xu Yu Wang Ying Chen Jianghua | 2012 | American Journal of Nephrology2012，，3： | 1 |
| 20 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
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