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| 1 | “癌症”的诊断对患者及其亲属的影响调查显示文摘目的 研究“癌症”诊断对居澳华裔患者及其亲属的影响。方法 采用定性研究策略 ,对象在悉尼 3所主要教学医院和 1个华裔肿瘤病人支持机构随机选择、并不断补充直至没有新信息出现为止 ,完成了 4个聚焦小组和 2 6个个别电话会谈 ,共调查了 36位癌症患者和 12位亲属。结果 结果发现“癌症”诊断对患者及其亲属的情绪、日常生活、事业、家庭与社会关系、患者的自身形象及亲属的心身健康均造成负面影响。大部分人的心理调节存在一定问题。结论 提示肿瘤医学应注重将生物 -心理 -社会医学模式切实应用于临床 ,各专业机构和社区应帮助该人群进行有效的心理调节。 | 黄雪薇 Phyllis Butow David Goldstein | 2001 | 中国公共卫生2001，17，10： | 32 |
| 2 | 血浆儿茶酚胺肾素醛固酮与血压的昼夜节律显示文摘目的 探讨昼夜血压呈非杓型、杓型、超杓型分布的高血压病患者中血浆儿茶酚胺、肾素与醛固酮水平的昼夜波动特征及其与血压时间生物学特征的关系。方法 入选新近诊断未经治疗的高血压病患者 10 4例 ,据其昼夜血压分布特征分为三组 :非杓型组 ;杓型组 ;超杓型组。分别测定各组患者的血浆肾上腺素、去甲肾上腺素、肾素、醛固酮水平 (每 4h 1次 ,连续测 6次 ) ,并应用余弦拟合法分析其时间生物学特征。结果 各组患者的上述 4种检测指标均表现为昼夜节律。非杓型组与超杓型组的肾上腺素和去甲肾上腺素昼夜平均水平及超杓型组的波动振幅均高于杓型组 ,非杓型组患者儿茶酚胺的振幅低于杓型组。超杓型组醛固酮的振幅明显高于杓型组 ,三组间肾素时间生物学特征无显著区别。结论 不同昼夜血压分布特征的高血压病患者 ,其血浆儿茶酚胺的时间生物学特征明显不同 。 | 郭艺芳 Phyllis K.Stein 姚丽霞 宋光耀 Peter P.Domitrovich | 2004 | 中华心血管病杂志2004，32，1： | 31 |
| 3 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 4 | 癌症与精神病人亲属心身状况及改善对策的跨文化探讨显示文摘目的研究居澳华裔及国内癌症及精神病人亲属的健康状况。方法以深层面谈和电话会谈、问卷法调查居澳华裔、居国内的癌症和精神病患者及其亲属共288人。结果绝大部分亲属有不同程度的焦虑、抑郁,伴有失眠、疲劳、衰弱等症状。2.78%~11.11‰被诊断为焦虑症、抑郁症或各种心身疾病。癌症病人亲属的健康状况随病人病情的波动而变化;精神病人亲属的健康状况随病人病情的进展和时间的推移趋向稳定。国内组与澳洲组表现有一定的差别。他们希望有完善的机构与设施帮助照顾其患病的亲人。结论建立完善的机构为癌症及精神病患者提供照顾等服务,帮助其亲属进行有效的心理调节,保持心身健康,是21世纪的国际性课题之一。 | 黄雪薇 郭宝江 Phyllis Butow James Telfer David Goldstein | 2006 | 中国健康心理学杂志2006，14，2： | 13 |
| 5 | β-受体阻滞剂对血小板凝聚性近日节律的影响显示文摘目的 探讨冠心病患者血小板凝聚力的昼夜变化节律以及 β 受体阻滞剂对其的影响。方法 共入选 4 6例冠心病患者 ,其中男性 33例 ,女性 13例 ;年龄 32~ 6 7(49± 9)岁。在常规基础治疗2周后 ,抽采血样 (4h一次 ,2 4h内共 6次 )测定其血小板聚集力。然后给患者服用美托洛尔 (2 5mg ,每日 2次 ) ,2周后重复测定血小板聚集功能。应用余弦拟合法分析其昼夜分布曲线的近日节律。结果 统计分析表明 ,美托洛尔治疗前后患者血小板凝聚力的昼夜分布均表现为近日节律。美托洛尔治疗对血小板凝聚力的 2 4h中值 (6 4 0 6 5 3对 6 1 6 6 3 0 ,P >0 0 5 )与峰值相位 (10 1° 98°对 115° 116°,P >0 0 5 )无显著影响 ,但显著降低了其峰值水平 (振幅 10 0 9 9对 4 0 5 2 ,P <0 0 0 1)。结论 冠心病患者血小板凝聚力存在近日节律 ,美托洛尔治疗对其昼夜平均水平无显著影响 ,但可有效抑制清晨觉醒后数小时内血小板凝聚性的迅速升高现象 ,可能有助于降低这一时段内缺血性心脏事件发作的危险性。 | 郭艺芳 Phyllis K.Stein 宋光耀 Peter P.Domitrovich | 2002 | 中华心血管病杂志2002，30，9： | 8 |
| 6 | Auditors’ Organizational Form, Legal Liability, and Reporting Conservatism: Evidence from China*显示文摘 | MICHAELFIRTH PHYLLIS L. L.MO RAYMOND M. K.WONG | 2012 | Contemporary Accounting Research2012，，1： | 6 |
| 7 | Oxygen administration in the care of neonates: a double-edged sword显示文摘在过去在出生不满一月的婴儿评估氧的使用的目的,现在和数据主要从有从1940年代的相关出版文章的 Pubmed 到有一些信息的礼品的未来数据来源从评估氧的使用在的网 searches.Study 选择研究聚在一起早熟并且通过有在那里的原来的里程碑文章 included.Results 的历史的学期婴儿仍然是关于合适的使用的许多 unknowns 在 preterm 和学期婴儿的氧但是许多研究建议那 | Phyllis A. Dennery | 2010 | Chinese Medical Journal2010，，20： | 5 |
| 8 | A Political–economic Analysis of Auditor Reporting and Auditor Switches显示文摘 | K. Hung Chan Kenny Z. Lin Phyllis Lai-lan Mo | 2006 | Review of Accounting Studies2006，，1： | 3 |
| 9 | Plant responses to arbuscular mycorrhizae under elevated temperature and drought显示文摘Aims Climate change is predicted to cause both increased temperatures and changes in precipitation,leading to more severe droughts in some areas.How these changes will affect plant growth may depend in part on biotic context.Most vascular plants form symbiotic rela-tionships with arbuscular mycorrhizal fungi(AMF),root symbionts that provide soil nutrients to plants in exchange for carbohydrates,which may reduce the effects of environmental stresses on plants.We investigated if AMF modified temperature and drought effects on plant growth,fitness and defenses against herbivory.Methods We manipulated AMF presence,temperature and water availability on bell pepper plants(Capsicum annuum L.)in a field setting to measure plant growth and fitness responses.In a growth chamber experiment,we also investigated if AMF influenced insect herbi-vores feeding on plants at elevated temperatures.Important findings Drought consistently reduced plant growth,and AMF did not change drought impacts.However,with sufficient water,AMF tended to benefit plant growth and flower production(but not fruit production)compared to non-mycorrhizal plants.In the growth chamber,temperature and AMF influenced plant protein and phos-phorus contents,but not defensive chemistry or herbivore perfor-mance.Thus,AMF may ameliorate the effects of temperature stress due to climate change on plants by increasing growth and nutrient content,but these effects do not extend to the constitutive herbivory defenses examined here. | Phyllis H.Pischl Nicholas A.Barber | 2017 | Journal of Plant Ecology2017，10，4： | 3 |
| 10 | Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort显示文摘AIM:To determine the rates and impact of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections on response to long-term highly active antiretroviral therapy(HAART) in a large human immunodeficiency virus(HIV) population in Nigeria.METHODS:HBV and HCV as well as HIV infections are endemic in sub Saharan Africa.This was a retrospective cohort study of 19 408 adults who were recruited between June 2004 and December 2010 in the AIDS Prevention Initiative in Nigeria in Nigeria programme at Jos University Teaching Hospital.Serological assays,including HBV surface antigen(HBsAg) and hepatitis C antibody were used to categorise hepatitis status of the patients.HBsAg was determined using enzyme immunoassay(EIA)(Monolisa HBsAg Ultra3;Bio-Rad).HCV antibody was tested using third generation EIA(DIA.PRO Diagnostic,Bioprobes srl,Milan,Italy).HIV RNA levels were measured using Roche COBAS Amplicor HIV-1 monitor test version 1.5(Roche Diagnostics,GmbH,Mannheim,Germany) with a detection limit of 400 copies/mL.Flow cytometry was used to determine CD4+ cell count(Partec,GmbH Munster,Germany).Comparison of categorical and continuous variables were achieved using Pearson's χ 2 and Kruskal Wallis tests respectively,on MedCalc for Windows,version 9.5.0.0(MedCalc Software,Mariakerke,Belgium).RESULTS:With an overall hepatitis screening rate of over 90% for each virus;HBV,HCV and HBV/HCV were detected in 3162(17.8%),1983(11.3%) and 453(2.5%) HIV infected adults respectively.The rate of liver disease was low,but highest among HIV monoinfected patients(29,0.11%),followed by HBV coinfected patients(15,0.08%).Patients with HBV coinfection and triple infection had higher log 10 HIV RNA loads(HBV:4.6 copies/mL vs HIV only:4.5 copies/mL,P<0.0001) and more severe immune suppression(HBV:645,55.4%;HBV/HCV:97,56.7%) prior to initiation of HAART compared to HIV mono-infected patients(1852,48.6%)(P<0.0001).Of 3025 patients who were 4.4 years on HAART and whose CD4 cell counts results at baseline and end of follow up were available for analyses,CD4 increase was significantly lower in those with HBV co-infection(HBV:144 cells/mm3 ;HBV/HCV:105 cells/mm3) than in those with HCV co-infection(165 cells/mm3) and HIV mono-infection(150 cells/mm3)(P=0.0008).CONCLUSION:High rates of HBV and HCV infections were found in this HIV cohort.CD4 recovery was significantly diminished in patients with HBV co-infection. | Nimzing Gwamzhi Ladep Patricia Aladi Agaba Oche Agbaji Auwal Muazu Placid Ugoagwu Godwin Imade Graham Cooke Sheena McCormack Simon David Taylor-Robinson John Idoko Phyllis Kanki | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 11 | Appropriate use of GI endoscopy显示文摘 | Dayna S. Early Tamir Ben-Menachem G. Anton Decker John A. Evans Robert D. Fanelli Deborah A. Fisher Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Phyllis M. Malpas John T. Maple Ravi S. Sharaf Jason A. Dominitz Brooks D. Cash | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 12 | Pay Disparities Within Top Management Groups: Evidence of Harmful Effects on Performance of High-Technology Firms显示文摘 | Phyllis A. Siegel Donald C. Hambrick | 2005 | Organization Science2005，，3： | 2 |
| 13 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 14 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 15 | Cancer statistics, 2000显示文摘 | Robert T.Greenlee TaylorMurray SherryBolden Phyllis A.Wingo | 2008 | CA: A Cancer Journal for Clinicians2008，，1： | 2 |
| 16 | Heart rate is an independent predictor of all-cause mortality in individuals with type 2 diabetes: The diabetes heart study显示文摘AIM To assess the association of resting heart rate with allcause and cardiovascular disease(CVD) mortality in the Diabetes Heart Study(DHS).METHODS Out of a total of 1443 participants recruited into the DHS, 1315 participants with type 2 diabetes who were free of atrial fibrillation and supraventricular tachycardia during the baseline exam were included in this analysis. Heart rate was collected from baseline resting electrocardiogram and mortality(all-cause and CVD) was obtained from state and national death registry. Kaplan-Meier(K-M) and Cox proportional hazard analyses were used to assess the association.RESULTS The mean age, body mass index(BMI) and systolic blood pressure(SBP) of the cohort were 61.4 ± 9.2 years, 32.0 ± 6.6 kg/m2, and 139.4 ± 19.4 mmHg respectively. Fiftysix percent were females, 85% were whites, 15% were blacks, 18% were smokers. The mean ± SD heart rate was 69.8(11.9) beats per minute(bpm). After a median follow-up time of 8.5 years(maximum follow-up time is 14.0 years), 258 participants were deceased. In K-M analysis, participants with heart rate above the median had a significantly higher event rate compared with those below the median(log-rank P = 0.0223). A one standard deviation increase in heart rate was associated with allcause mortality in unadjusted(hazard ratio 1.16, 95%CI: 1.03-1.31) and adjusted(hazard ratio 1.20, 95%CI: 1.05-1.37) models. Similar results were obtained with CVD mortality as the outcome of interest.CONCLUSION Heart rate is an independent predictor of all-cause mortality in this population with type 2 diabetes. In this study, a 1-SD increase in heart rate was associated with a 20% increase in risk suggesting that additional prognostic information may be gleaned from this ubiquitously collected vital sign. | Sameer Prasada Cameron Oswalt Phyllis Yeboah Georgia Saylor Donald Bowden Joseph Yeboah | 2018 | World Journal of Diabetes2018，9，1： | 2 |
| 17 | Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health Study显示文摘 | Phyllis K. Stein Devang Sanghavi Nona Sotoodehnia David S. Siscovick John Gottdiener | 2010 | Journal of Electrocardiology2010，，3： | 2 |
| 18 | Occurrence and distribution of vibrios in fishes and shellfishes in coastal waters of Hong Kong显示文摘The summer occurrence and distribution of vibrios in the fishes and shellfishes in the coasal waters of Hong Kong were investigaed. A total of 69 strains of vibrios were isolated from all samples examined. The strains, along with 10 reference strains were classified with the technique of numerical taxonomy bared on 54 characters and 62 of the 69 strains fell into 5 major phena, identified as V. paraheamolyticus (30 strains), V. alginoloticus (23 strains), V. choloerae (3 strains), V. harveyi (2 strains) and V. fluinalis (4 strains). Among them, V.paraheamolyticus and V. alginolyticus were the predominant species in the fishes, shellfishes and the coastal waters of Hong Kong and comprised 43. 5 % and 33. 3 % of the total Vibrio spp. isolates respectively. Meanwhile, 3 strains of non-Ol V. cholerae were isolated from oyster and it was the first time to record V. cholerae non-Ol in seawater or from shellfishes in Hong Kong. These results highlighted the potential risks of food poisoning associated with raw or undercooked seafood. | Xu Huaishu, Li Jun, (College of Marine Life Sciences, Ocean University of Qingdao, Qingdao 266003, China)Phyllis Brayton, Rita R. Colwell, David Swartz, (University of Maryland, College Park, 20742, USA)Norman Y. S. Woo, Zhang Shuting (Department of Biol | 1998 | Acta Oceanologica Sinica1998，17，4： | 2 |
| 19 | Nutrient intake and congenital heart defects in maternal phenylketonuria显示文摘 | Kimberlee MM Phyllis A Colleen A | 2002 | Am J Obstet Gynecol2002，187，2： | 1 |
| 20 | Story telling from pictures using the Edmonton Narrative Norms Instrument显示文摘 | Phyllis S Denyse H Rita Vis Dube | 2006 | Journal of Speech Pathology and Audiology2006，30，4： | 1 |
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