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| 1 | Genetics of hepatocellular carcinoma显示文摘The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis. | Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen Peter R Galle | 2007 | World Journal of Gastroenterology2007，13，16： | 21 |
| 2 | 相变材料微胶囊悬浮液在矩形小通道内层流流动传热的实验显示文摘本文进行了对比性的实验,以研究相变材料微胶囊(MEPCM)-水悬浮液在水力直径为2.71mm的矩形小通道内的层流流动传热性能。实验中用的MEPCM颗粒的平均粒径为4.97μm,与蒸馏水混合制备成质量浓度范围为0~20%的MEPCM-水悬浮液。对比性的实验是指,在相同的悬浮液质量流量和热力条件下,使用不同浓度的MEPCM悬浮液进行传热实验。实验发现,MEPCM悬浮液的冷却性能严重依赖于悬浮液的质量流量和悬浮液的质量浓度。质量浓度为5%的悬浮液在在整个质量流量范围内总是表现出比水好的冷却性能,它对应的是更低的壁面温度以及更好的传热系数。而对于更高质量浓度的悬浮液,在低质量流量的情况下,它们具有很好的冷却性能;而在高质量流量的情况下,它们表现出的冷却性能比水更差,它们对应更高的壁面温度以及更低的Nusselt数。 | 饶宇 Frank Dammel Peter Stephan 林贵平 | 2006 | 航空动力学报2006，21，6： | 18 |
| 3 | Update on autoimmune hepatitis显示文摘Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology that occurs in children and adults of all ages. Characteristics are its autoimmune features,hyperglobulinemia (IgG),and the presence of circulating autoantibodies,as well as a response to immunosuppressant drugs. Current treatment consists of prednisone and azathioprine and in most patients this disease has become very treatable. Over the past 2 years,a couple of new insights into the genetic aspects,clinical course and treatment of AIH have been reported,which will be the focus of this review. In particular,we concentrate on genome-wide microsatellite analysis,a novel mouse model of AIH,the evaluation of a large AIH cohort for overlap syndromes,suggested novel criteria for the diagnosis of AIH,and the latest studies on treatment of AIH with budenoside and mycophenolate mofetil. | Andreas Teufel Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，9： | 17 |
| 4 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 5 | 氮与自然显示文摘在某种程度上,人类对全球氮循环的改变是很重要的,因为增加的氮极大地改变了许多天然生态系统的组成、生产率和其它性质。增加的氮为什么有这么大的影响力?为什么如此多的天然生态系统都处于缺氮状态?减缓氮相对于其它元素的循环过程,和控制生态系统水平的氮输入输出过程,都使氮供应成为生态系统动态的限制因子。我们讨论了可以减慢氮循环的因子陆地植物和其它有机体之间的化学计量学差异,蛋白质沉淀防御植物的多度,土壤有机质中C-N键状态。对输入来讲,氮固定的能量消耗及其后果,氮以外的养分供应,对固氮者的优先取食,所有这些都能限制生物固氮者的多度和/或活动。这些过程加在一起,推动和维持着许多天然陆地生态系统的氮限制。 | Peter M.Vitousek Stephan Htttenschwiler Lydia Olander Steven Allison 王胜 | 2002 | AMBIO-人类环境杂志2002，31，2： | 7 |
| 6 | Review of the impact of heat stress on reproductive performance of sheep显示文摘Heat stress significantly impairs reproduction of sheep,and under current climatic conditions is a significant risk to the efficiency of the meat and wool production,with the impact increasing as global temperatures rise.Evidence from field studies and studies conducted using environmental chambers demonstrate the effects of hot temperatures(≥32℃)on components of ewe fertility(oestrus,fertilisation,embryo survival and lambing)are most destructive when experienced from 5 d before until 5 d after oestrus.Temperature controlled studies also demonstrate that ram fertility,as measured by rates of fertilisation and embryo survival,is reduced when mating occurs during the period 14 to 50 d post-heating.However,the contribution of the ram to heat induced reductions in flock fertility is difficult to determine accurately.Based primarily on temperature controlled studies,it is clear that sustained exposure to high temperatures(≥32℃)during pregnancy reduces lamb birthweight and will,therefore,decrease lamb survival under field conditions.It is concluded that both ewe and ram reproduction is affected by relatively modest levels of heat stress(≥32℃)and this is a concern given that a significant proportion of the global sheep population experiences heat stress of this magnitude around mating and during pregnancy.Despite this,strategies to limit the impacts of the climate on the homeothermy,behaviour,resource use and reproduction of extensively grazed sheep are limited,and there is an urgency to improve knowledge and to develop husbandry practices to limit these impacts. | William H.E.J.van Wettere Karen L.Kind Kathryn L.Gatford Alyce M.Swinbourne Stephan T.Leu Peter T.Hayman Jennifer M.Kelly Alice C.Weaver David O.Kleemann Simon K.Walker | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 7 | Flow frictional characteristics of microencapsulated phase change material suspensions flowing through rectangular minichannels显示文摘An experimental investigation was conducted on the laminar flow frictional characteristics of suspensions with microencapsulated phase change material (MEPCM) in water flowing through rectangular copper minichannels. The MEPCM was provided at an average particle size of 4.97 μm, and was mixed with distilled water to form suspen- sions with various mass concentrations ranging from 0 to 20%. The experiment was per- formed to explore the effect of MEPCM mass concentration on friction factor and pressure drop in the minichannels. The Reynolds number ranged from 200 to 2000 to provide laminar and transitional flows. It was found that the experimental data for the suspensions with 0 and 5% concentration agree well with the existing theoretical data for an incom- pressible, fully developed, laminar Newtonian flow. For the suspensions with mass con- centrations higher than 10%, there is an obvious increase in friction factor and pressure drop in comparison with laminar Newtonian flow. | Frank Dammel Peter Stephan | 2006 | Science China(Technological Sciences)2006，49，4： | 6 |
| 8 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 9 | 麦肯锡关于中国寿险业的最新研究报告(上)显示文摘中国的持续发展面临来自经济和社会的双重挑战。中国政府可以通过积极发展人寿保险行业来应对这些挑战。当前,中国政府的相关部门已经逐步认识到人寿保险的利益,并已经开始采取措施来促进中国人寿保险行业的发展。中国政府可考虑采取以下五个方面的措施来推动寿险业最大限度地发挥其作用和潜力:首先是加强教育,让百姓认识到人寿保险的作用和益处;其次是鼓励保险机构为广大农民及落后地区服务;第三是加强监管机构的力量;第四是为寿险行业创造更多的市场机会;最后是为保险机构和参保企业或个人提供优惠的税收政策。 | Peter Walker Tab Bowers Stephan Binder 胡忠兵 安琳 | 2006 | 四川经济研究2006，，1： | 5 |
| 10 | Mucosal healing and deep remission: What does it mean?显示文摘The use of specific terms under different meanings and varying definitions has always been a source of confusion in science.When we point our efforts towards an evidence based medicine for inflammatory bowel diseases(IBD)the same is true:Terms such as'mucosal healing'or'deep remission'as endpoints in clinical trials or treatment goals in daily patient care may contribute to misconceptions if meanings change over time or definitions are altered.It appears to be useful to first have a look at the development of terms and their definitions,to assess their intrinsic and context-independent problems and then to analyze the different relevance in present-day clinical studies and trials.The purpose of such an attempt would be to gain clearer insights into the true impact of the clinical findings behind the terms.It may also lead to a better defined use of those terms for future studies.The terms'mucosal healing'and'deep remission'have been introduced in recent years as new therapeutic targets in the treatment of IBD patients.Several clinical trials,cohort studies or inception cohorts provided data that the long term disease course is better,when mucosal healing is achieved.However,it is still unclear whether continued or increased therapeutic measures will aid or improve mucosal healing for patients in clinical remission.Clinical trials are under way to answer this question.Attention should be paid to clearly address what levels of IBD activity are looked at.In the present review article authors aim to summarize the current evidence available on mucosal healing and deep remission and try to highlight their value and position in the everyday decision making for gastroenterologists. | Gerhard Rogler Stephan Vavricka Alain Schoepfer Peter L Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 11 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 4 |
| 12 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 13 | 麦肯锡关于中国寿险业的最新研究报告(下)显示文摘过去20年间,中国经济和社会都发生了一系列巨大变化。在中国经济高速发展以及工业化进程快速推进的同时,也给国家带来了很大的压力,具体表现在如何为基础设施建设筹措足够的资金,以及如何完善和发展中国的社会保障体系两方面。大力发展寿险业可以有效地解决上述问题。麦肯锡公司基于其在中国人寿保险行业的经验,以及在亚洲、欧洲和全球其他国家人寿保险行业的长期经验,撰写了一份关于中国寿险业发展的研究报告:《积极发展寿险行业促进中国经济持续增长及社会稳定和谐》。泣报告具有一定的理论及现实价值,本刊已在2006年第1期刊登了该报告的上半部分,本期继续刊登该报告的下半部分内容,以供广大读者参考。 | Peter Walker Tab Bowers Stephan Binder 胡忠兵 安琳 | 2006 | 保险研究2006，，2： | 4 |
| 14 | Ontology Dynamics in a Data Life Cycle: Challenges and Recommendations from a Geoscience Perspective显示文摘Ontologies are increasingly deployed as a computer-accessible representation of key semantics in various parts of a data life cycle and, thus, ontology dynamics may pose challenges to data management and re-use. By using examples in the field of geosciences, we analyze challenges raised by ontology dynamics, such as heavy reworking of data, semantic heterogeneity among data providers and users, and error propagation in cross-discipline data discovery and re-use. We also make recommendations to address these challenges:(1) communities of practice on ontologies to reduce inconsistency and duplicated efforts;(2) use ontologies in the procedure of data collection and make them accessible to data users; and(3) seek methods to speed up the reworking of data in a Semantic Web context. | Xiaogang Ma Peter Fox Eric Rozell Patrick West Stephan Zednik | 2014 | Journal of Earth Science2014，25，2： | 3 |
| 15 | Widely tunable 2.3μm III-V-on-silicon Vernier lasers for broadband spectroscopic sensing显示文摘Heterogeneously integrating III-V materials on silicon photonic integrated circuits has emerged as a promising approach to make advanced laser sources for optical communication and sensing applications. Tunable semiconductor lasers operating in the 2–2.5 μm range are of great interest for industrial and medical applications since many gases(e.g., CO_2, CO, CH_4) and biomolecules(such as blood glucose) have strong absorption features in this wavelength region. The development of integrated tunable laser sources in this wavelength range enables low-cost and miniature spectroscopic sensors. Here we report heterogeneously integrated widely tunable III-V-on-silicon Vernier lasers using two silicon microring resonators as the wavelength tuning components. The laser has a wavelength tuning range of more than 40 nm near 2.35 μm. By combining two lasers with different distributed Bragg reflectors, a tuning range of more than 70 nm is achieved. Over the whole tuning range, the side-mode suppression ratio is higher than 35 dB. As a proof-of-principle, this III-V-on-silicon Vernier laser is used to measure the absorption lines of CO. The measurement results match very well with the high-resolution transmission molecular absorption(HITRAN) database and indicate that this laser is suitable for broadband spectroscopy. | RUIJUN WANG STEPHAN SPRENGEL ANTON VASILIEV GERHARD BOEHM JORIS VAN CAMPENHOUT GuY LEPAGE PETER VERHEYEN ROEL BAETS MARKUS-CHRISTIAN AMANN GUNTHER ROELKENS | 2018 | Photonics Research2018，6，9： | 3 |
| 16 | 糖基化终产物对脉络膜微血管内皮细胞增生和管腔形成的影响(英文)显示文摘目的:研究糖基化终产物(advanced glycationendproducts, AGEs)在年龄相关性黄斑变性发生中的作用。方法:使用lycopersiconesculentum agglutinin包被磁珠的改良方法分离牛脉络膜微血管内皮细胞(bovine choroidalendothelialcells, CEC),采用抗VIII因子免疫细胞化学法和摄取低密度脂蛋白(dil-acetylated low-density lipoprotein,dil-ac-LDL)法进行细胞鉴定。将50g/L牛血清白蛋白和150g/L葡萄糖在37℃孵育6wk 以制备AGEs,通过抗-AGEs 抗体点杂交法定性分析。用MTT 法(3,(4,5-dimethylthiazol-2-yl)-2,5- diphenyl te-trazolium bromide assay)测定CEC 增生,用Vit-rogen凝胶系统观察管腔形成情况。结果:培养细胞中90%以上呈因子阳性,并具有摄取dil-ac-LDL的能力,表明具有内皮细胞的特征。制备的AGEs 与抗-AGEs 抗体具有亲和力。浓度在62.5~500mg/L范围内的AGEs 处理CEC 3d 后,细胞增生呈剂量依赖性增加。碱性成纤维细胞生长因子(basic fibroblastgrowth factor, bFGF)可明显增强CEC 中管腔样结构的形成(P <0.05),但500mg/L和50mg/L的AGEs 对CEC 管腔形成无明显影响(P >0.05)。结论:AGEs 可以促进CEC 的增生,但对其管腔形成无影响。提示AGEs 通过增强CEC 增生,可能是渗出型AMD 发病中潜在的启动因子之一? | 王雨生 Ulrike Friedrichs Wolfram Eichler Stephan Hoffmann Peter Wiedemann | 2005 | 国际眼科杂志2005，5，2： | 3 |
| 17 | 小型激光天文动力学空间计划概念显示文摘小型激光天文动力学空间计划是 :使用在太阳轨道上无拖曳航天器和地面站以激光干涉和脉冲测距的方法 ,精确地探讨天文动力学 ,检测相对论与时空基本定律 ,改进探测引力波的灵敏度以及更准确地测定太阳、行星和小行星的参数。 1 969年开始的月球激光 (反射 )测距 ,对地球物理、参考坐标的选定、相对论的检验均有重要的贡献。 3 0年来 ,激光技术的长足进步 ,使现在正是适合于开始进行研究空间有源 (主动 )测距和光波空间通讯的时候。激光天文动力学的兴起是必然的趋势 ,其精确度将比现在提高 3到 6个数量级 ,将是天文动力学革命性的发展。小型激光天文动力学空间计划可以起到带头作用。它的关键技术有三 ,即 :弱光锁相、极精确无拖曳航天和高衰减日冕仪。弱光锁相已有长足的进步。对高衰减日冕仪的研究 ,也有了初步的方案。LISA空间计划将于 2 0 0 6年 8月发射SMART -2 ,研究测试极精确无拖曳航天。小型激光天文动力学空间计划的关键技术已日趋成熟。在第一届国际激光天文动力学研讨会 ( 2 0 0 1 ,9.1 3 -2 3 )中介绍了各相关学科背景及前沿研究 ,讨论了激光天文动力学空间计划科学目标及相关技术 ,并召开了两次小型激光天文动力学空间计划预研究筹备会 ,建立了和欧洲的合作关系。会后着手进行此项对基础? | 倪维斗 朱进 武向平 褚桂柏 杨彬 高健 关敏 汤健仁 周翊 张中豪 黄天衣 曲钦岳 易照华 李广宇 陶金河 吴岸明 罗俊 叶贤基 周泽兵 熊耀恒 毕少兰 须重明 吴雪君 唐孟希 包芸 李芳昱 黄珹 杨福民 叶叔华 张书练 张元仲 聂玉昕 陈光 Joergen Christensen-Dalsgaard Hansjoerg Dittus Yasunori Fujii Claus Laemmerzahl Jean Francois Mangin Achim Peters Albrecht Ruediger Etienne Samain Stephan Schiller | 2002 | 云南天文台台刊2002，，3： | 3 |
| 18 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 19 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 20 | 快速响应喷头评估显示文摘介绍了快速响应喷头与标准响应喷头相比在技术及经济上的优势。 | Peter Thomas Stephan Grosskopff 梁吉林 沙琮勋 | 2006 | 消防技术与产品信息2006，19，3： | 2 |
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