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	题名	作者	年代	出处	被引量
1	Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.	C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf	2014	World Journal of Cardiology2014，6，4：	3
2	Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘	Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt	2012	Journal of the American College of Cardiology2012，，18：	2
3	High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults With “Idiopathic” Left Ventricular Dysfunction显示文摘	Uwe Kühl Matthias Pauschinger Michel Noutsias Bettina Seeberg Thomas Bock Dirk Lassner Wolfgang Poller Reinhard Kandolf Heinz-Peter Schultheiss	2005	Circulation2005，，7：	2
4	Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection in peripheral blood显示文摘	Jeserich M Brunner E Kandolf R	2013	The international journal of cardiovascular imaging2013，29，1：	1
5	Molecular mechanisms in the pathogenesis of enterovirus heart disease : acute and persistent infection 显示文摘	Kandolf R Kingel K Zell R	1993	Clin Immunol & Immunopathol1993，68，2：	1
6	Proliferation of human primary vascular smooth muscle cells depends on serum response factor显示文摘	Daniela Werth Gabriele Grassi Nina Konjer Barbara Dapas Rossella Farra Carlo Giansante Reinhard Kandolf Gianfranco Guarnieri Alfred Nordheim Olaf Heidenreich	2010	European Journal of Cell Biology2010，，2：	1
7	Catecholamine refractory'cardiogenic shock?bridging-to-recovery'by implantation of a percutaneous cardiac assist device显示文摘	Wilde J Klingel K Kandolf R	2013	DMW:Deutsche Medizinische Wochenschrift2013，138，12：	1
8	Die laparoskop ische Therapie der Damendam etriose under Stellenuert denned ikam entosen therapies (Laparoscopie therapy of intestinal endometriosis and the rank of drug treatment) 显示文摘	Keckstein JU Irigh U Kandolf O	2003	Zentralbl-Gynakol2003，125，78：	1
9	Predictors of Outcome in Patients With Suspected Myocarditis显示文摘	Ingrid Kindermann Michael Kindermann Reinhard Kandolf Karin Klingel Burkhard Bültmann Thomas Müller Angelika Lindinger Michael B?hm	2008	Circulation2008，，6：	1
10	The role of enterovirus replication in the development of acute and chronic heart muscle disease in defferent immunocompetent mouse strains 显示文摘	Klingel K Kandolf R	1993	Scand J Infect Dis Suppl1993，88，1：	1
11	Cardiovascular Magnetic Resonance in Clinically Suspected Cardiac Amyloidosis显示文摘	Holger Vogelsberg Heiko Mahrholdt Claudia C. Deluigi Ali Yilmaz Eva M. Kispert Simon Greulich Karin Klingel Reinhard Kandolf Udo Sechtem	2008	Journal of the American College of Cardiology2008，，10：	1
12	Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘	Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem	2006	Circulation2006，，15：	1
13	High Prevalence of Cardiac Parvovirus B19 Infection in Patients With Isolated Left Ventricular Diastolic Dysfunction显示文摘	C Tsch?pe C -T. Bock M Kasner M Noutsias D Westermann P -L. Schwimmbeck M Pauschinger W -C. Poller U Kühl R Kandolf H -P. Schultheiss	2005	Circulation2005，，7：	1
14	Virus?tiologie der inflammatorischen Kardiomyopathie显示文摘	R Kandolf	2004	Dtsch med Wochenschr2004，，41：	1
15	The role of enterovirus replication in the development of acute and chronic hear muscle disease in defferent immunocompetent mouse strains显示文摘	Klingel K Kandolf R	1993	Scand J Infect Dis Suppl1993，88，1：	1
16	Early growth response-1 gene(Egr-1) promother induction by ionizing radiation in U87 malignant glioma cells in vitro显示文摘	Meyer RG Kupper JH Kandolf R at al	2002	Eur J Biochem2002，269，1：	1
17	Molecular mechanisms in the path ogenesis of enterovirus heart disease: acute and persistent infection 显示文摘	Kandolf R Kingel K Zell R	1993	Chin Immunol & Immunopathol1993，68，2：	1
18	Molecular pathology of inflammatory cardiomyopathy显示文摘	Karin Klingel Martina Sauter C. Thomas Bock Gudrun Szalay Jens-J?rg Schnorr Reinhard Kandolf	2004	Medical Microbiology and Immunology (-)2004，，2：	1
19	Molecular mechanisms in the pathogensis of enteroviral heart disease: acute and persistent infections 显示文摘	Kandolf R Kliogei K Zell R	1993	Clin lmuno lmmunopathol1993，68，2：	1
20	Molecular mechanisms in the pathogenesis of enteroviral heart disease:acute and persistent infections显示文摘	Kandolf R Klingel K Zell R	1993	Clin Immunol Immunopathol1993，68，2：	1

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