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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis显示文摘 | Bernard Uzzan Régis Cohen Patrick Nicolas Michel Cucherat Gérard-Yves Perret | 2006 | Critical Care Medicine2006，，7： | 2 |
| 3 | Construction of an oilseed rape (Brassica napus L.) genetic map with SSR markers显示文摘 | J. Piquemal E. Cinquin F. Couton C. Rondeau E. Seignoret I. doucet D. Perret M.-J. Villeger P. Vincourt P. Blanchard | 2005 | Theoretical and Applied Genetics2005，，8： | 2 |
| 4 | Regulation of Torpor in the Gray Mouse Lemur:Transcriptional and Translational Controls and Role of AMPK Signaling显示文摘The gray mouse lemur(Microcebus murinus) is one of few primate species that is able to enter daily torpor or prolonged hibernation in response to environmental stresses. With an emerging significance to human health research, lemurs present an optimal model for exploring molecular adaptations that regulate primate hypometabolism. A fundamental challenge is how to effectively regulate energy expensive cellular processes(e.g., transcription and translation) during transitionsto/from torpor without disrupting cellular homeostasis. One such regulatory mechanism is reversible posttranslational modification of selected protein targets that offers fine cellular control without the energetic burden. This study investigates the role of phosphorylation and/or acetylation in regulating key factors involved in energy homeostasis(AMP-activated protein kinase, or AMPK, signaling pathway), m RNA translation(eukaryotic initiation factor 2a or e IF2 a, eukaryotic initiation factor 4E or e IF4 E, and initiation factor 4E binding protein or 4EBP), and gene transcription(histone H3) in six tissues of torpid and aroused gray mouse lemurs. Our results indicated selective tissue-specific changes of these regulatory proteins. The relative level of Thr172-phosphorylated AMPKa was significantly elevated in the heart but reduced in brown adipose tissue during daily torpor, as compared to the aroused lemurs, implicating the regulation of AMPK activity during daily torpor in these tissues. Interestingly, the levels of the phosphorylated e IFs were largely unaltered between aroused and torpid animals. Phosphorylation and acetylation of histone H3 were examined as a marker for transcriptional regulation. Compared to the aroused lemurs, level of Ser10-phosphorylated histone H3 decreased significantly in white adipose tissue during torpor, suggesting global suppression of gene transcription. However, a significant increase in acetyl-histone H3 in the heart of torpid lemurs indicated a possible stimulation of transcriptional activity of this tissue. Overall, our study demonstrates that AMPK signaling and posttranslational regulation of selected proteins may play crucial roles in the control of transcription/translation during daily torpor in mouse lemurs. | Jing Zhang Shannon N.Tessier Kyle K.Biggar Cheng-Wei Wu Fabien Pifferi Martine Perret Kenneth B.Storey | 2015 | Genomics, Proteomics & Bioinformatics2015，13，2： | 2 |
| 5 | The Wnt/β-catenin pathway as a therapeutic target in human hepatocellular carcinoma显示文摘 | Rajae Dahmani Pierre-Alexandre Just Christine Perret | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，11： | 2 |
| 6 | Uncoupling protein 2 negatively regulates insulin secretion and is amajor link between obesity, beta celldys function, and type 2 diabetes 显示文摘 | Zhang CY Baffy G Perret P | 2001 | Cell2001，105，6： | 1 |
| 7 | Three-dimensional quantification of macropore networks in undisturbed soil cores显示文摘 | PERRET J PRASHER S O KANTZAS A | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 8 | Hydroxylated human homotrimeric collagen Ⅰ in Agrobacterium tumefaciens mediated transient expression and in transgenic tobacco plants显示文摘 | Merle C Perret S Lacour T | 2002 | FEBS Lett2002，，515： | 1 |
| 9 | Genetic susceptibilities inthe association between maternal exposure to tobacco smoke andthe risk of nonsyndromic oral cleft显示文摘 | Chevrier C Bahuau M Perret C | 2008 | Am J Med Genet A2008，146，18： | 1 |
| 10 | Connected image processing with nmltivariate attributes: An unsupervised Markovian classification approach 显示文摘 | PERRET B COLLET C | 2015 | Computer Vision and Image Understanding2015，133，4： | 1 |
| 11 | High- and lowresolution mass spectrometry coupled to liquid chromatography as confirmatory methods of anabolic residues in crude meat and infant foods 显示文摘 | GENTILI A SERGI M PERRET D | 2006 | Rapid Communications in Mass Spectrometry2006，20，12： | 1 |
| 12 | δ-Viniferin,a resveratrol dehydrodimer:One of the major stilbenes synthesized by stressed grapevine leaves显示文摘 | Pezet R Perret C Jean-Dents J B | 2003 | J Agric Food Chem2003，51，： | 1 |
| 13 | EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma显示文摘 | Terris B Cavard C Perret C | 2010 | 52(2):280-2812010，52，2： | 1 |
| 14 | Study of the relation- ship between pre-harvest sprouting and grain color by quanti- tative trait loci analysis in a white X red grain bread-wheat cross 显示文摘 | Groos C Gay G Perretant M R | 2002 | Theoretical and Applied Genetics2002，104，： | 1 |
| 15 | Non-antibiotic properties of tetracyclines and their clinical application i1 dermatology 显示文摘 | Perret LJ Tait CP | 2014 | Australas J Dermatol2014，55，2： | 1 |
| 16 | Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity,beta cell dysfunction,and type 2 diabetes显示文摘 | Baffy G Perret P | 2001 | Cell2001，106，6： | 1 |
| 17 | Effect of gliadins and HMW and LMW subunits of glutenin on dough properties in the F6 recombinant inbred lines from a bread wheat cross显示文摘 | NIETO-TALADRIZ M T PERRETANT M R ROUSSET M | 1994 | Theoretical and Applied Genetics1994，88，： | 1 |
| 18 | Improving the yellow pigment content of bread wheat flour by selecting the three homoeologous copies of Psy1显示文摘 | Catherine Ravel Mireille Dardevet Fanny Leenhardt Jacques Bordes Jean Louis Joseph Marie Reine Perretant Florence Exbrayat Charles Poncet Fran?ois Balfourier Elisabeth Chanliaud Gilles Charmet | 2013 | Molecular Breeding2013，，1： | 1 |
| 19 | Liquid chromatngraphy-tandem mass spectrometry for peffo Tning confirmatory analysis of veterinary drugs in animal-food products显示文摘 | Gentili A Perret D Marchese S | 2005 | Trends Anal Chem2005，24，： | 1 |
| 20 | Antitumor active beta - D -glucans from phytophthora parasitica显示文摘 | Fabre I Perret J Michel G | 1988 | Carbohydr Res1988，175，1： | 1 |
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