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| 1 | The Potato Sucrose Transporter StSUT1 Interacts with a DRM-Associated Protein Disulfide Isomerase显示文摘进建筑群的蛋白质的组织为许多细胞的功能是关键的。最近, SUT1 蛋白质被显示形成 homodimeric 建筑群,到与类脂化合物被联系在酵母以及在植物并且到的像木排的 microdomains 响应 brefeldin A 经历 endocytosis。我们因此试图识别可能涉及 dimerization 的交往 SUT1 蛋白质, endocytosis,或 SUT1 指向到像木排的 microdomains。因此,我们识别了土豆膜蛋白质,它与净化抵抗的膜(DRM ) 被联系部分。在识别的蛋白质之中,我们清楚地在土豆来源叶子作为 DRM 的部分证实了 StSUT1。我们使用了酵母二混血儿的裂口 ubiquitin 系统(怀疑) 系统地在 vivo 为在蔗糖 transporter StSUT1 和另外的联系膜或可溶的蛋白质之间的相互作用屏蔽。SUS 屏幕被 immunoprecipitation 用净化亲密关系的 StSUT1 特定的肽抗体和一同沉淀的蛋白质的集体度谱的分析跟随。大重叠在在 co-immunoprecipitation 和净化抵抗的膜部分识别的交往 StSUT1 蛋白质之间被观察。交往 SUT1 蛋白质之一,蛋白质二硫化物 isomerase (PDI ) ,与另外的蔗糖 transporter 蛋白质也交往。护卫蛋白质被讨论的 PDI 的一个潜在的角色。 | Undine Krugel Hong-Xia He Konstanze Gier Jana Reins Izabela Chincinska Bernhard Grimm Waltraud X. Schulze Christina Kuhn | 2012 | Molecular Plant2012，5，1： | 7 |
| 2 | 甘薯细胞壁蔗糖转化酶基因IbCWIN家族成员鉴定及表达分析显示文摘甘薯是重要的粮食、饲料、工业原料作物和新型的生物能源作物,细胞壁蔗糖转化酶是植物源、库组织蔗糖代谢的关键酶,但关于甘薯细胞壁蔗糖转化酶基因IbCWIN家族成员的研究尚未见报道。本研究测定供试品种不同组织部位的蔗糖淀粉含量,利用生物信息学方法对IbCWIN基因家族的理化性质、保守结构域、系统进化关系、启动子作用元件、组织特异性表达模式进行分析。结果表明,甘薯茎中蔗糖含量最高,须根和叶次之,块根最低;块根淀粉含量最高,极显著高于其他部位。甘薯中含有10个IbCWIN基因,编码氨基酸442~1115个,蛋白质分子量范围49.56~124.44kD,等电点为5.0~9.1。分布在8条染色体上,都含有Glyco_32保守结构域及相同或相似的保守基序motif,属于糖基水解酶基因家族GH32。IbCWIN与木薯MeCWINV同源性高,IbCWIN基因家族启动子区域含有多种类型的顺式作用元件。qRT-PCR结果表明,IbCWIN基因家族在甘薯不同组织中均有表达且有多种表达模式,其中IbCWIN2和IbCWIN9在块根中表达量显著高于其他组织部位。本研究为下一步探索甘薯IbCWIN基因家族的功能及调控甘薯源、库关系机制提供理论指导。 | 宋天晓 刘意 饶莉萍 Soviguidi Deka Reine Judesse 朱国鹏 杨新笋 | 2021 | 作物学报2021，47，7： | 6 |
| 3 | 难处理金矿的热压氧化预处理显示文摘世界上第一个应用热压氧化工艺处理难处理金矿的工业化提金厂是基于Sherritt连续扩大试验所收集的数据来设计的,从那时起,已有五个其它的工业化工厂在Sherritt试验和技术的基础上建起来。本文论述了处理难处理金矿的热压氧化工艺的一般概念以及在工艺设计中比较重要的物料特性。 | 林燕 Mike Collins Rein Raudsepp | 2009 | 世界有色金属2009，，7： | 5 |
| 4 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 5 | 甘薯苯丙氨酸解氨酶基因IbPAL的克隆与表达分析显示文摘本研究基于甘薯(Ipomoea batatas(L.)Lam.)与绿原酸合成代谢相关的转录组数据克隆了苯丙氨酸解氨酶基因IbPAL,通过蛋白序列比对、系统进化分析、二级和三维蛋白结构预测、跨膜结构域以及启动子分析,对该基因的氨基酸序列和启动子序列的结构特征进行了解析;通过qRT-PCR技术分析该基因在不同甘薯品种的根、茎、茎尖和叶中的表达情况,并对其进行亚细胞定位验证。结果显示,IbPAL的CDS序列全长2130 bp,编码709个氨基酸。其氨基酸序列与已知物种的氨基酸序列同源性在80%以上。IbPAL蛋白以α螺旋和随机卷曲为主,具有1个可能的跨膜螺旋区。该基因启动子中包含多个顺式作用元件。表达模式分析结果表明,IbPAL主要在茎和茎尖中表达,其在甘薯品种‘EC16’4个组织器官中的表达量均显著高于其他品种。亚细胞定位结果显示该基因在细胞膜和细胞核上均可以表达。 | 饶莉萍 苏文瑾 刘意 宋天晓 Soviguidi Deka Reine Judesse 杨新笋 张文英 | 2020 | 植物科学学报2020，38，3： | 3 |
| 6 | 小剂量瑞芬太尼对全麻苏醒拔管期不良反应的作用显示文摘背景瑞芬太尼可以减轻全麻苏醒期时的咳嗽、躁动和血流动力学变化等不良反应。方法在一项前瞻性、随机、双盲临床试验中,60例接受鼻部手术的成人患者采用以瑞芬太尼为基础的麻醉方案。在苏醒期,瑞芬太尼组患者将瑞芬太尼用量减至维持量的1/10,而对照组患者则停止使用。结果两组患者的苏醒时间和气管拔管时间无明显区别。与对照组相比,瑞芬太尼组在苏醒期(输注速率:0.014±0.011μg·kg·min^-1)的咳嗽发生率(40%vs80%,P=0.002)和严重程度均明显减轻,不自主运动发生率降低(3.3%vs30%,P=0.006),心率较慢。结论在苏醒期使用小剂量瑞芬太尼不会延长苏醒时间,且降低气管插管所致咳嗽的发生率和严重程度。 | Marie T. Aouad Achir A. Al-Alami Viviane G. Nasr Fouad G. Souki Reine A. Zbeidy Sahar M. Siddik-Sayyid 韩柳(译) 李成辉(校) | 2010 | 麻醉与镇痛2010，，6： | 3 |
| 7 | Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii(Harms) J.Leonard stem barks (Caesalpiniaceae) in mice and rats显示文摘Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its safety.Methods: NMRI mice were used to determine the acute toxicity of G. tessmannii.Increasing concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 days.In order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ weights.Results: LD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical parameters.Conclusions: The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake. | Noreen Orianna Koumba Madingou Aristide Traore Alain Souza Marlaine Michelle Boukandou Mounanga Raissa Reine Aworet Samseny Sylvin Ouedraogo Alfred Sababenedyo Traore | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 2 |
| 8 | Seasonal tourism spaces in Estonia: Case study with mobile positioning data显示文摘 | Rein Ahas Anto Aasa ülar Mark Taavi Pae Ain Kull | 2006 | Tourism Management2006，，3： | 2 |
| 9 | Location based services—new challenges for planning and public administration?显示文摘 | Rein Ahas ülar Mark | 2004 | Futures2004，，6： | 2 |
| 10 | Intracardiac Echogenic Foci Have No Hemodynamic Significance in the Fetus显示文摘 | Zeev Perles Amiram Nir Sagui Gavri Julius Golender Azaria J. J. T. Rein | 2010 | Pediatric Cardiology2010，，1： | 2 |
| 11 | Cold spray deposition: significance of particle impact phenomena 显示文摘 | S V Klinkov V F Kosarev M Rein | 2005 | Aerospace Science and Technology2005，9，： | 1 |
| 12 | Weekly Carboplatin and Docetaxel for Locally Advanced Primary and Recurrent Cervical Cancer: A Phase I Study 显示文摘 | Rein DT Kurbacher CM Breidenba M | 2002 | Gynecologic Oncology2002，87，1： | 1 |
| 13 | Face detection in color images 显示文摘 | Hsu Rein Lien Abdel | 2002 | IEEE Transaction on Pattern Analysis and Machine Infellgence2002，24，5： | 1 |
| 14 | Weekly carboplatin and docetaxel for locally advanced primary and recurrent cervical cancer:a phase Ⅰ study显示文摘 | Rein DT Kurbacher CM Breidenbach M | 2002 | Gynecol Oncol2002，87，1： | 1 |
| 15 | NT-pro-BNP as a marker for persistent cardiac disease in children with history of dilated cardiomyopathy and myocarditis显示文摘 | Nasser N Perles Z Rein A J | 2006 | Pediatr Cardiol2006，27，： | 1 |
| 16 | Expression of renal and intestinal NalPi cotransporters in the absence of GABARJkP 显示文摘 | Reining S C Liesegang A Betz H | 2010 | Pfluigers Arch2010，460，： | 1 |
| 17 | The economic burden of major adult visual disorders in theUnited States显示文摘 | Rein DB Zhang P Wirth KE | 2006 | Arch Ophthalmol2006，124，12： | 1 |
| 18 | Analysis of the Ventilation Systems in the Dartford Tunnels using a Multi- scale Modelling Approach 显示文摘 | COLELLA F REIN G CARVEL R O | 2010 | Tunneling and Underground Space Technology2010，，25： | 1 |
| 19 | 查看详情显示文摘 | Song W H Teshiba T Rein K | | 0，，： | 1 |
| 20 | Cranioplasty after decompressive hemicraniectomy:Underestimated surgery-associated complications显示文摘 | Doro thee Watcher Kim Rein eke Timor Behm | | 0，，： | 1 |
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