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| 1 | Enhanced myocardial fluorodeoxyglucose uptake following Adriamycin-based therapy: Evidence of early chemotherapeutic cardiotoxicity?显示文摘AIM: To analyze changes in myocardial glucose metabolism using fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients treated with adriamycin and to investigate the clinical significance of these changes.METHODS: Considering that FDG-PET scanning has the ability to show changes in glucose metabolism in the myocardium, we retrospectively analyzed the FDGPET studies of 18 lymphoma patients treated with adriamycin-based chemotherapy in both the preand posttherapy setting. Cardiac contractile parameters such as left ventricular ejection fraction were not available for correlation in all patients due to the short duration and the level of cumulative dose administered in these patients during the time of the follow-up FDG-PET study. The change in myocardial glucose utilization was estimated by change in standard uptake values (SUV) in the myocardium.RESULTS: We observed a significant change in SUVmean values in the myocardium (defined as more than change in cardiac SUVmean between pre-and post-chemotherapy PET) in 1 patients, whereas 6 patients did not show any significant cardiac FDG uptake in both preand post-therapy PET scans. Patients were divided into three groups based on the changes observed in myocardial tracer uptake on the followup 18 F-FDG-PET study. Group A (n = 8): showed an increase in cardiac 18 F-FDG uptake in the post-therapy scan compared to the baseline scan carried out prior to starting adriamycin-based chemotherapy. Group B (n = 6): showed no significant cardiac 18 F-FDG uptake in post-therapy and baseline PET scans, and group C (n = 4): showed a fall in cardiac 18 F-FDG uptake in the posttherapy scan compared to the baseline scan. Mean cumulative adriamycin dose (in mg/m 2 ) received during the time of the follow-up FDG-PET study was 256. 25, 250 and 137.5, respectively.CONCLUSION: Our study shows three different trends in the change in myocardial glucose metabolism in patients undergoing adriamycin-based chemotherapy. A further prospective study with prolonged follow-up of ventricular function is warranted to explore the significance of enhanced FDG uptake as a marker of early identification of adriamycin-induced cardiotoxicity. | Chaitanya Borde Purushottam Kand Sandip Basu | 2012 | World Journal of Radiology2012，4，5： | 9 |
| 2 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 3 | Transmission ecology of rodent-borne diseases:New frontiers显示文摘Rodents are recognized reservoir hosts for many human zoonotic pathogens.The current trends resulting from anthropocene defaunation suggest that in the future they,along with other small mammals,are likely to become the dominant mammals in almost all human-modified environments.Recent intricate studies on bat-borne emerging diseases have highlighted that many gaps exist in our understanding of the zoonotic transmission of rodent-borne pathogens.This has emphasized the need for scientists interested in rodent-borne diseases to integrate rodent ecology into their analysis of rodent-borne pathogen transmission in order to identify in more detail the mechanisms of spillover and chains of transmission.Further studies are required to better understand the true impact of rodent abundance and the importance of pathogen sharing and circulation in multi-host–multi-pathogen communities.We also need to explore in more depth the roles of generalist and abundant species as the potential links between pathogen-sharing,co-infections and disease transmission. | Frédéric BORDES Kim BLASDELL Serge MORAND | 2015 | Integrative Zoology2015，10，5： | 2 |
| 4 | Normal gestations and live births after orthotopic autograft of vitrified - warmed hemi - ovaries into ewes显示文摘 | Bordes A Lomage J Demirci B | 2005 | Human Reproduction2005，20，10： | 1 |
| 5 | Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells显示文摘 | BORD M R | 1996 | Antimicrobial Angents and Chemotherapy1996，40，5： | 1 |
| 6 | Estrogen receptors a and β are differential expressed in developing human bone显示文摘 | Bord S Homer A Beavan S | 2001 | J Clin Endocrinol Metab2001，86，5： | 1 |
| 7 | Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘 | D'ANGELO J G BORD N C POSNER GH | 2009 | J Antimicrob Chemother2009，63，1： | 1 |
| 8 | Sentinel lymph node biopsy after neoadjuvant chemotherapy for advanced breast cancer: results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante, a French prospective muhicentric study 显示文摘 | Classe JM Bordes V Campion L | 2009 | J Clin Oncol2009，27，5： | 1 |
| 9 | Fast kernel classifiers with online and active learning显示文摘 | Antoine Bordes Seyda Ertekin Jason Westou | 2005 | J of Machine Learning Research2005，6，9： | 1 |
| 10 | Risk of liquidity and contagion of the crisis on the united states, united kingdom and Euro zone money markets显示文摘 | Blancheton B Bordes C Maveyraud S Rous P | 2012 | Inter-national Journal of Finance & Economics2012，，17： | 1 |
| 11 | Membrane PKC-beta 2protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma显示文摘 | Espinosa I Bfiones J Bordes R | | 0，，09： | 1 |
| 12 | Characterization of OpuA, a glycine-betaine uptake system of Lactoeoccus lactis显示文摘 | Bouvier J Bordes P Romeo Y | | 0，，： | 1 |
| 13 | Colocalization of glu- cocorticoid and mineralocorticoid receptors in human bone 显示文摘 | Beavan S Homer A Bord S | 2001 | J Bone Miner Res2001，16，： | 1 |
| 14 | Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha,interleukin 1,and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts显示文摘 | O' Gradaigh D Ireland D Bord S | 2004 | Ann Rheum Dis2004，63，4： | 1 |
| 15 | Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage显示文摘 | HORNER A BISHOP NJ BORD S | 1999 | J Anat1999，194，4： | 1 |
| 16 | Sentinel lymph nodebiopsy after neoadjuvant chemotherapy for advanced breast cancer:results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante,a French prospective multicentric study显示文摘 | Classe JM Bordes V Campion L | 2009 | J Clin Oncol2009，27，5： | 1 |
| 17 | Oxidation of ethane to ethylene and acetic acid by MoVNbO catalysts显示文摘 | ROUSSEL M BOUCHARD M BORDES R E | 2005 | Catal Today2005，99，12： | 1 |
| 18 | Improving the yellow pigment content of bread wheat flour by selecting the three homoeologous copies of Psy1显示文摘 | Catherine Ravel Mireille Dardevet Fanny Leenhardt Jacques Bordes Jean Louis Joseph Marie Reine Perretant Florence Exbrayat Charles Poncet Fran?ois Balfourier Elisabeth Chanliaud Gilles Charmet | 2013 | Molecular Breeding2013，，1： | 1 |
| 19 | Production of collagenase by human osteoblasts and osteoclasts in vivo显示文摘 | Bord S Homer A Hembry RM | 1996 | Bone1996，19，1： | 1 |
| 20 | A clinical trial of mupirocin in the eradication of methicillin-resistant staphylococcus aureus nasal carriage in a digestive disease unit显示文摘 | Dupeyron C Campillo B Bordes M | 2002 | J Hosp Infect2002，52，4： | 1 |
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