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| 1 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Hybridization analysis of Chesapeake Bay virioplankton 显示文摘 | WOMMACK K E RAVEL J HILL R T | 1999 | Applied and Environmental Microbiology1999，65，1： | 1 |
| 3 | Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes:from metabolic fluxes to gene expression显示文摘 | Kohl C Ravel D Girard J | 2002 | Diabetes2002，51，8： | 1 |
| 4 | Predictive, structurebased model of amino acid recognition by nonribosomal peptide synthetase adenylation domains 显示文摘 | Challis G L Ravel J Townsend C A | 2000 | Chem Biol2000，7，： | 1 |
| 5 | Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5显示文摘 | Paulsen IT Press CM Ravel J | 2005 | Nature Biotechnology2005，23，7： | 1 |
| 6 | The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1 显示文摘 | Rasko D A Ravel J Okstad O A | 2004 | Nucleic Acids Res2004，32，3： | 1 |
| 7 | Improving the yellow pigment content of bread wheat flour by selecting the three homoeologous copies of Psy1显示文摘 | Catherine Ravel Mireille Dardevet Fanny Leenhardt Jacques Bordes Jean Louis Joseph Marie Reine Perretant Florence Exbrayat Charles Poncet Fran?ois Balfourier Elisabeth Chanliaud Gilles Charmet | 2013 | Molecular Breeding2013，，1： | 1 |
| 8 | Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes? 显示文摘 | Medina - Ravell VA Lankipalli RS Yan GX | 2003 | Circulation2003，107，5： | 1 |
| 9 | Coeliehelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase显示文摘 | Challis G L Ravel J | 2000 | FEMS Microbiol Lett2000，187，2： | 1 |
| 10 | Preparation and microwave characterization of spherical and monodisperse CoNi particles显示文摘 | RAVEL F ACHER P | 1994 | Appl Phys1994，，10： | 1 |
| 11 | Beneficial effects of Neoty- phodium lolii on the growth and the water status in perennial ryegrass cultivated under nitrogen deficiency or drought stress 显示文摘 | Ravel F Courty C Coret A | 1997 | Agronomie1997，17，1： | 1 |
| 12 | Lan- gerin, anovel C-type lectin specific to Langerhans ceils, is endocytie receptor that induces the formation of Bir- beck granules显示文摘 | Valladeau J Ravel O Dezutter-Dambuyant C | 2000 | Immunity2000，12，1： | 1 |
| 13 | Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter显示文摘 | Tzukerman M Shachaf C Ravel Y | 2000 | Mol Biol Cell2000，11，12： | 1 |
| 14 | A preliminary study of the population genetics of Aedes aegypti (Diptera:Culicidae) from Mexico using microsatellite and AFLP markers显示文摘 | RAVEL S MONTENY N VELASCO OLMOS D | 2001 | Acta Tropica2001，78，3： | 1 |
| 15 | Vaginal microbiome of reproduc- tive-age women显示文摘 | Ravel J Gajer P Abdo Z | 2011 | Proc Nat Acad Sci U S A2011，108，1： | 1 |
| 16 | Beneficial effects of Neotyphodium lolii on the growth and the water status in perennial ryegrass cultivated under nitrogen deficiency or drought stress显示文摘 | RAVEL F COURTY C CORET A | 1997 | Agronomie1997，17，： | 1 |
| 17 | Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization显示文摘 | Lankipalli RS Yan GX | 2003 | Circulation2003，1，5： | 1 |
| 18 | A proposal for the reclassification of Bdellovibrio stolpii and Bdellovibrio starrii into a new genus,Bacteriovorax gen nov as Bacteriovorax stolpii comb nov and Bacteriovorax starrii comb nov respectively显示文摘 | Baer ML Ravel J Chun J | 2000 | International journal of systematic and evolutionary microbiology2000，，1： | 1 |
| 19 | Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains 显示文摘 | Challis G L Ravel J Townsend C A | 2000 | Chem Biol2000，7，： | 1 |
| 20 | New molecular marker for Trypanosoma (Duttonella) vivax identification 显示文摘 | Ravel S Grebaut P | 2001 | Acta Trop2001，80，3： | 1 |
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