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		题名	作者	年代	出处	被引量
	1	Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program显示文摘BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been shown.AIM To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening campaign.METHODS This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December 2019.Delay between test_((-1))and test_((0))was>1year and test_((-1))result was negative(<150 ngHb/mL).The severity of colorectal lesions diagnosed at test_((0))was described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression model.RESULTS The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of zero.This risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to an increased risk of severity of colorectal lesions.This risk of severity increased among first-time participants(age<55)and the elderly(≥70).To avoid the loss of chance in these age groups,the FIT positivity threshold should be reduced to 100 ngHb/mL.The other alternative would be to reduce the time between the two tests in these age groups from the current 2 years to 1 year.	Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie Clerc Claire Piccotti Anne Deloraine Catherine Exbrayat	2021	World Journal of Gastroenterology2021，27，31：	2
	2	Improving the yellow pigment content of bread wheat flour by selecting the three homoeologous copies of Psy1显示文摘	Catherine Ravel Mireille Dardevet Fanny Leenhardt Jacques Bordes Jean Louis Joseph Marie Reine Perretant Florence Exbrayat Charles Poncet Fran?ois Balfourier Elisabeth Chanliaud Gilles Charmet	2013	Molecular Breeding2013，，1：	1
	3	Immunocytochemical localization and ultrastructural study of gonadotroph cells in the female desert lizard Uromastyx acanthinura 显示文摘	Hammouche S Gernigon T Exbrayat J M	2007	Tissue Cell2007，，39：	1
	4	SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000显示文摘	Roussel V Leisova L Exbrayat F	2005	Theor Appl Genet2005，111，：	1
	5	Cytokeratin expression in human oral gingival epithelial cells: in vitro regulation by titanium-based implant materials 显示文摘	Lagneau C Farges JC Exbrayat P	1998	Biomaterials1998，19，1112：	1
	6	Immunolocalization of hepatic estrogen and progesterone receptors in the female lizard Uromastyx acanthinura 显示文摘	Hammouche S B Remana S Exbrayat J M	2012	Comptes Rendus Biologies2012，335，7：	1
	7	Analysis and classification of interval cancers in a French breast cancer screening programme显示文摘	Garnier A Colonna M	1999	Eur J Cancer Prey1999，8，3：	1
	8	SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000 显示文摘	Roussel V Leisova L Exbrayat F	2005	Theor Appl Genet2005，111，：	1
	9	SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000 显示文摘	Roussel V Leisova L Exbrayat F	2005	Theor Appl Genet2005，111，：	1
	10	SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000 显示文摘	Roussel V Leisova F Exbrayat Z	2005	Theoretical and Applied Genetics2005，111，：	1
	11	SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000 显示文摘	Roussel V Leisova L Exbrayat F	2005	Theor Appl Genet2005，111，：	1
	12	Effect of New Machinable Ceramic on Behavior of Rat Bone Cells Cultured in Vitro显示文摘	Dubois JC Exbrayat P Couble ML	1998	J Biomed Mater Res1998，43，：	1

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