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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Leaves of Field-Grown Mastic Trees Suffer Oxidative Stress at the Two Extremes of their Lifespan显示文摘Leaf senescence is a complex phenomenon occurring in all plant species, but it is still poorly understood in plants grown in Mediterranean field conditions and well-adapted to harsh climatic conditions. To better understand the physiological processes underlying leaf senescence in mastic trees (Pistacia lentiscus L.), we evaluated leaf growth, water and N content, photosystem II (PSII) photochemistry, lipid peroxidation and levels of photosynthetic pigments, antioxidants, abscisic acid, and salicylic acid and jasmonic acid during the complete leaf lifespan, from early expansion to late senescence in relation to natural climatic conditions in the field. While mature leaves suffered from water and N deficit during late spring and summer, both young (emerging) and old (senescing) leaves were most sensitive to photo-oxidative stress, as indicated by reductions in the F v/F m ratio and enhanced lipid peroxidation during late autumn and winter. Reductions in the F v/F m ratio were associated with low α-tocopherol (vitamin E) levels, while very old, senescing leaves additionally showed severe anthocyanin losses. We have concluded that both young (emerging) and old (senescing) leaves suffer oxidative stress in mastic trees, which may be linked in part to suboptimal temperatures during late autumn and winter as well as to low vitamin E levels. | Marta Juvany Maren Müller Sergi Munn-Bosch | 2012 | Journal of Integrative Plant Biology2012，54，8： | 2 |
| 3 | New techniques and technolo-gy to repair cerebrospinal fluid rhinorrhea显示文摘 | Paludetti G Sergi B Rigante M | 2004 | Acta Otorhinolaryngol Ital2004，24，3： | 1 |
| 4 | High- and lowresolution mass spectrometry coupled to liquid chromatography as confirmatory methods of anabolic residues in crude meat and infant foods 显示文摘 | GENTILI A SERGI M PERRET D | 2006 | Rapid Communications in Mass Spectrometry2006，20，12： | 1 |
| 5 | The Meta-analysis of impact of drug class on adherence to antihypertensives显示文摘 | Kronish IM Woodward M Sergie Z | 2011 | Cir- culation2011，123，15： | 1 |
| 6 | Anti-cancer PEG-enzymes: 30 years old, but still a current approach 显示文摘 | Pasut G Sergi M Veronese FM | 2008 | Adv Drug Deliv Rev2008，60，1： | 1 |
| 7 | Separation of biodiesel and glycerol using ceramic membranes显示文摘 | SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T | 2010 | JournalofMembraneScience2010，352，2： | 1 |
| 8 | Drought-induced changes in the redox state of alpha-tocopherol,ascorbate and the diterpene carnosic acid in chloroplasts of labiatae species differing in carnosic acid contents显示文摘 | SERGI M B LRNONOR A | 2003 | Plant Physiology2003，131，： | 1 |
| 9 | Endocrine complications in patients with Thalassemia Major 显示文摘 | Toumba M Sergis A Kanaris C | 2007 | Pediatr Endocrinol Rev2007，5，2： | 1 |
| 10 | Anti-cancer PEG-enzymes:30 years old, but still a current approach显示文摘 | Pasut G Sergi M Veronese FM | 2008 | Adv Drug Deliv Rev2008，60，1： | 1 |
| 11 | Degration of disperse azo dyes from waters by solar photoelectro-Fenton 显示文摘 | SALAZAR Ricardo GARCIA Segura Sergi URETA-Zafiartu M S | 2011 | Electrochinica Acta2011，56，： | 1 |
| 12 | An open-ended question:Alzheimer's disease and involuntary weight loss:Which comes first?显示文摘 | Inelmen E M Sergi G Coin A | 2010 | Aging Clin Exp Res2010，22，3： | 1 |
| 13 | New techniques and technology to repair cerebrospinal fluid rhinorrhea 显示文摘 | Paludetti G Sergi B Rigante M | 2004 | Acta Otorhinolaryngol Ital2004，24，3： | 1 |
| 14 | Meta-analysis : impact of drug class on adherence to antihypertensives 显示文摘 | Kronish IM Woodward M Sergie Z | 2011 | Circulation2011，123，15： | 1 |
| 15 | Study of 22-year-old Arrow oil samples using biomarker compounds by GC/MS显示文摘 | Wang Z Fingas M Sergy G | 1994 | Environmental Science & Technology1994，28，9： | 1 |
| 16 | Discordant outcomes in a case of parvovirus b19 transmission into both dichorionic twins显示文摘 | Schiesser M Sergi C Enders M | 2009 | Twin Res Hum Genet2009，12，2： | 1 |
| 17 | Nanochanics of lipid bilayers by force spectroscopy with AFM: A perspective显示文摘 | Sergi C M Fausto S | 2010 | BBABiomenbranes2010，1798，： | 1 |
| 18 | Micro-solid phase extraction coupled with high-performance liquid chromatographytandem mass spectrometry for the determination of stimulants,hallucinogens,ketamine and phencyclidine in oral fluids显示文摘 | Sergi M Compagnone D Curini R | 2010 | Anal Chim Acta2010，675，2： | 1 |
| 19 | Prevalence of normal tension glaucoma in obstructive sleep apnea syndrome patients 显示文摘 | Sergi M Salemo DE Rizzi M Blini M Andreoli A Messenio D | 2007 | Glaucoma2007，15，： | 1 |
| 20 | Determination of Hg and organomercury species following SPME : A review显示文摘 | Sergi Dtez Josep M Bayona | 2008 | Talanta2008，77，1： | 1 |
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