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| 1 | Spin probes for electron paramagnetic resonance imaging显示文摘Electron paramagnetic resonance imaging (EPRI) is a relatively recent imaging technique, which provides potentially multidimensional imaging of the spatial distribution of paramagnetic species. Thanks to the use of stable spin probes, low frequency EPR imaging has recently allowed the use of large tissue samples or whole animals in vivo in the field of biology and medicine. It is normally necessary to introduce prior intravenous or intramuscular infusion of stable or slowly metabolizable non-toxic water-soluble paramagnetic materials, or stable implantable particulate materials as spin probes into the system. The classification and research progress of spin probes at present were described briefly. Three important potential approaches in water-soluble paramagnetic materials design including deuterated, site-specific and macromolecular conjugated nitroxides were also investigated. | YAN GuoPing PENG Lei JIAN ShuangQuan LI Liang BOTTLE Steven Eric | 2008 | Chinese Science Bulletin2008，53，24： | 7 |
| 2 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 3 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 4 | Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects显示文摘The aim of this study was to apply the reference-scaled average bioequivalence(RSABE)approach to evaluate the bioequivalence of 2 formulations of agomelatine,and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects.This was performed in a single-dose,randomized-sequence,open-label,four-way crossover study with a one-day washout period between doses.Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation.The formulations were considered bioequivalent if 90% confidence intervals(CIs)for the log-transformed ratios and ratio of geometric means(GMR)of AUC and C_(max) of agomelatine were within the predetermined bioequivalence range based on RSABE method.Results showed that both of the90% CIs for the log-transformed ratios of AUC and C_(max) of 7-desmethyl-agomelatine and 3-hydroxyagomelatine were within the predetermined bioequivalence range.The 90% CIs for natural logtransformed ratios of C_(max) ,AUC_(0–t)and AUC_(0–∞) of agomelatine(104.42–139.86,101.33–123.83 and97.90–117.94)were within the RSABE acceptance limits,and 3-hydroxy-agomelatine(105.55–123.03,101.95–109.10 and 101.72–108.70)and 7-desmethyl-agomelatine(104.50–125.23,102.36–111.50 and101.62–110.64)were within the FDA bioequivalence definition intervals(0.80–1.25 for AUC and0.75–1.33 for C_(max)).The RSABE approach was successful in evaluating the bioequivalence of these two formulations. | Fang Tang Rui Zhou Zeneng Cheng Guoping Yang Aiqiao Chen Zhi Liu Hongyi Tan Shuang Yang Sanwang Li Lingli Mu Peng Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 2 |
| 5 | Piezoelectric Actuator Placement Optimization and Active Vibration Control of a Membrane Structure显示文摘The placement optimization of piezoelectric actuators and active vibration control of a membrane structure are studied in this paper. The classical linear quadratic regulator controllers are designed to suppress the unwanted vibration. Simulation results indicate that the optimal locations of piezoelectric actuators are affected deeply by the additional mass and stiffness of actuators, the computational efficiency of particle swarm optimizer is higher than that of genetic algorithm for this particular problem, and the control performance of optimally placed actuators is better than that of non-optimally placed actuators. | Xiang Liu Guoping Cai Fujun Peng Hua Zhang | 2018 | Acta Mechanica Solida Sinica2018，31，1： | 2 |
| 6 | Probability Forecast of Regional Landslide Based on Numerical Weather Forecast显示文摘The regional forecast of landslide is one of the key points of hazard mitigation. It is also a hot and difficult point in research field. To solve this problem has become urgent task along with Chinese economy fast development. This paper analyzes the principle of regional landslide forecast and the factors for forecasting. The method of a combination of Information Value Model and Extension Model has been put forward to be as the forecast model. Using new result of Numerical Weather Forecast Research and that combination model, we discuss the implementation feasibility of regional landslide forecast. Finally, with the help of Geographic Information System, an operation system for southwest of China landslide forecast has been developed. It can carry out regional landslide forecast daily and has been pilot run in NMC. Since this is the first time linking theoretical research with meteorological service, further works are needed to enhance it. | GAO Kechang WEI Fangqiang CUI Peng HU Kaiheng XU Jing ZHANG Guoping BI Baogu | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 2 |
| 7 | Robust mixed H2/H= state-feedback control for continuous-time descriptor systems with parameter uncertainties 显示文摘 | XIA Yuanqing SHI Peng LIU Guoping | 2005 | Circuits Systems Signal Processing2005，24，4： | 1 |
| 8 | Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway显示文摘尽管螺旋体 interrogans 是不能的作为它的碳 / 精力利用葡萄糖,采购原料, L 的 LA_1437 基因。interrogans serovar Lai 潜在地编码组 III glucokinase (GLK ) 。L。interrogans GLK (LiGLK ) 不同类地在 Escherichia 表示了 coli 被净化并且证明了是有它 12.3 的特定的活动的 homodimeric 酶 ? 桴 ? 慰瑲慩?? 潤慭湩愠摮渠牯慭?? 整浲湩獵? 獩猠潨瑲牥琠慨 ? 偁 ? 湡 ??? 戠 ? 桴 ? 敲獡湯漠 ? 敧敮映慲敭桳晩 ? 畭慴楴湯搠牵湩? | Qing Zhang Yunyi Zhang Yi Zhong Jun Ma Nanqiu Peng Xingjun Cao Chen Yang RongZeng Xiaokui Guo Guoping Zhao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 1 |
| 9 | Medical Image Edge Detection Based on EMD Method显示文摘As a new image analysis technique, Empirical Mode Decomposition (EMD) has been drawn more attention in recent years. In this paper, we proposed a fast EMD method for the edge detection of medical images. We implemented the method in the following steps: a) Decompose the original medical image with the image pyramid technique; b) Implement the EMD at the low resolution level image; c) Map the Intrinsic Mode Functions (IMFs) into the original image; d) Use the edge detector in a coarse IMF at the beginning of the procedure; e) Trace the detected result to the finest IMF to obtain the final image edge. Experimental results demonstrated the effectiveness of the proposed method. | PENG Shichun LIU Jian YAN Guoping | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 1 |
| 10 | Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats显示文摘 | Yang Xu Jingye Wang Xinghui Song Ruili Wei Fangping He Guoping Peng Benyan Luo | 2016 | Brain Research Bulletin2016，，： | 1 |
| 11 | A convenient method for the determination of molecular weight cut-off of ultrafiltration membranes显示文摘With the rapid increase of water contamination,membrane separation technology and their corresponding molecular weight cut-off(MWCO) evaluation method become more necessary.In this study,Panax notoginseng saponins was used as a new standard marker to determinate ultrafiltration(UF) membrane MWCOs,series of Millipore membranes were selected as control group to analyze and calculate the relationship between retention rate and MWCOs with exponential or logarithmic equation.A new and convenient method was provided for determining the membrane MWCO by modeling analysis retention rate with MWCOs,and the regression coefficients >0.990.The feasibility and practicability of established method was verified by different manufactures' membrane and dextrans.In the detection progress,as the main ingredient of Panax notoginseng saponins,Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd with different surface activity,the MWCO range of UF membranes can be divided into two zones mainly due to the retention rate difference among Notoginsenoside R_1,Ginsenoside Rg_1,Ginsenoside Rb_1 and Ginsenoside Rd.Zone 1,1000-10000;and Zone II,10000-100000.Thus,the new method would be helpful to improve the applicability of UF membrane in separation technology. | Cunyu Li Yun Ma Hongyang Li Guoping Peng | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 1 |
| 12 | PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients显示文摘 | Guoping Peng Shuping Li Wei Wu Xufei Tan Yiqiong Chen Zhi Chen | 2007 | Molecular Immunology2007，，4： | 1 |
| 13 | Circulating CD4 CD25 regulatory T cells correlate with chronic hepatitis B infection 显示文摘 | Peng Guoping Li Shuping Wu Wei | 2008 | Immunology2008，123，1： | 1 |
| 14 | An investigation of the optical properties of Tb 3+ -doped phosphate glasses for green fiber laser显示文摘 | Liaolin Zhang Mingying Peng Guoping Dong Jianrong Qiu | 2012 | Optical Materials2012，，7： | 1 |
| 15 | Synthesis and optical properties of chromium-doped spinel hollow nanofibers by single-nozzle electrospinning显示文摘 | Dong Guoping Xiao Xiudi Peng Mingying | 2012 | RSC Advances2012，2，： | 1 |
| 16 | Biochemical and molecular characterization of NAD +-dependent isocitrate dehydrogenase from the ethanologenic bacterium Zymomonas mobilis显示文摘 | Wang Peng Jin Mingming Zhu Guoping | | 0，，02： | 1 |
| 17 | Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase显示文摘 | Yingling Wei Ai-Yun Peng Bo Wang Lin Ma Guoping Peng Yidan Du Jingming Tang | 2014 | European Journal of Medicinal Chemistry2014，，： | 1 |
| 18 | GInR positive transcriptional regulation of the phosphate-specific transport system pstSCAB in Amycolatopsis mediterranei U32显示文摘 | Yuhui Zhang Yixuan Zhang Peng Li Ying Wang Jin Wang Zhihui Shao Guoping Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 0 |
| 19 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 20 | R&D of BEPCII 500 MHz superconducting cavity显示文摘Beijing Electron-Positron Collider Upgrade (BEPCII) adopts two 500 MHz superconducting cavities (SCCs) in each ring for higher accelerated gradient, higher Q and lower impedance (Wang et al. The proceedings of SRF'07). There's no spare cavity due to the limited time and funding during BEPCII construction. If any serious trouble happened on either one of the two cavities and could not be recovered in a short time, the operation of BEPCII facility will be affected. Therefore, since 2009 three spare cavities have been fabricated in China to ensure reliable operation, and two of them have been successfully vertically tested in January and July 2011. This paper will briefly present the manufacture, post-process and vertical test performance of the 500 MHz spare cavities. | LIU YaPing WANG GuangWei PAN WeiMin LI JiZhen LIU DeGui SUN Yi LI ZhongQuan DAI JianPing LI ShaoPeng HE Kun WANG GuoPing ZHAO GuangYuan MA Qiang LIN HaiYing SHA Peng WANG QunYao QIU Feng MENG FanBo LI Han | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 0 |
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