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| 1 | Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration显示文摘Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects.In traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the clinic.Fortunately,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour therapies.In addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to society.Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration.More interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option.Herein,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair.Furthermore,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future. | Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu Jinfeng Liao | 2021 | International Journal of Oral Science2021，13，1： | 9 |
| 2 | Ecological influence of exotic plants of Sonneratia apetala on understory macrofauna显示文摘The study aims to compare the differences of macrofauna communities of wetlands at 3-year-forest- age, 5-year-forest-age Sonneratia apetala artificial mangroves, 5-year-forest-age Kandelia candel ar- tificial mangroves with the same restoration background, and the naked tidal flat in the Qi'ao Island Mangrove Nature Reserve of Zhuhai, Guangdong Province. The results show that there were signif- icant structural differences in macrofauna communities among four kinds of habitats. The increase of biomass and species diversity of macrofauna at 3-year-forest-age S. apetala artificial mangroves was obviously faster than that at 5-year-forest-age K. candel artificial mangroves whose average tree height was close to that of 3-year-forest-age S. apetala artificial mangroves. The BIOENV analysis shows that it was related to the rapid growth of S. apetala, which rapidly changed the light level and shading conditions in the forests. The 5-year-forest-age S. apetala artificial mangroves had lower macrofauna species diversity but higher density and biomass than K. candel artificial mangroves with the same forest age. This was due to the rapid changes of physical and chemical properties of habitat soil by the ecological restoration of S. apetala artificial mangroves as well as the changed food sources possibly caused by the leaf-litter of such non-indigenous mangrove species S. apetala. However, further survey should be conducted on whether there are any negative ecological impacts of large-scale cultivation of S. apetala on macrofauna communities, so as to evaluate correctly S. apetala's role in the restoration of coastal mangrove ecosystems. | TANG Yijie FANG Zhanqiang CHEN Kang ZHANG Zaiwang ZHONG Yanting AN Dong YANG Xiongbang LIAO Baowen | 2012 | Acta Oceanologica Sinica2012，31，5： | 8 |
| 3 | Ecological indicators showing the succession of macrofauna communities in Sonneratia apetala artificial mangrove wetlands on Qi'ao Island at Zhuhai, South China显示文摘The Sonneratia apetala artificial mangroves in the intertidal zone of Da Wei Bay at Qi'ao Island of Zhuhai, South China were chosen as the macrofauna succession plots while bare tidal flats of the same size were established as control plots in surrounding interference-free areas. Conventional change indicators of community structure, such as biomass and biodiversity, and indicators, such as exergy and specific exergy, which reflect the information change of overall communities, were used to analyze the succession of macrofauna communities in S. apetala artificial mangroves. The similarities and differences in variation tendency of the different ecological indicators and their reflected ecological principles were compared. The results showed that from D-1 to D-1275 after planting S. apetala, the biomass of the macrofauna communities first increased, which was then followed by an increase in the network relationship between the macrofauna communities(analysis of the Pielou evenness index and Shannon-Wiener diversity index). The system information(specific exergy) increased the slowest. Between D-1460 and D-2370 after planting S. apetala, there was a decrease in biomass, network structure, and system information in the succession plots. After the decrease in the system information(the specific exergy), there was a decline in the network relationships(Pielou evenness index and Shannon-Wiener diversity index). Biomass was the last indicator to decrease. The similarities and differences among the different ecological indicators varied during the succession process, which reflected the relativity and differences among the indicators. This study suggested that, although the species diversity index can be an effective indicator of two types of changes(network structure and system information), it was quite clear that species diversity measurement was not suitable for expressing the changes in biomass during the succession process. While exergy and specific exergy can provide useful information about the structural development of communities, they cannot identify the information state of the system. Therefore, when evaluating macrofaunal succession in S. apetala artificial mangrove wetlands, it would be better to apply a number of different ecological indicators, rather than just one single indicator. | TANG Yijie FANG Zhanqiang ZHANG Zaiwang ZHONG Yanting CHEN Kang LIU Benhan FAN Junjie XIONG Tiantian LU Xiaosheng | 2014 | Acta Oceanologica Sinica2014，33，8： | 6 |
| 4 | Global analysis of lysine succinylation in patchouli plant leaves显示文摘Lysine succinylation is a novel,naturally occurring posttranslational modification(PTM)in living organisms.Global lysine succinylation identification has been performed at the proteomic level in various species;however,the study of lysine succinylation in plant species is relatively limited.Patchouli plant(P.cablin(Blanco)Benth.,Lamiaceae)is a globally important industrial plant and medicinal herb.In the present study,lysine succinylome analysis was carried out in patchouli plants to determine the potential regulatory role of lysine succinylation in patchouli growth,development,and physiology.The global succinylation sites and proteins in patchouli plants were screened with an immunoprecipitation affinity enrichment technique and advanced mass spectrometry-based proteomics.Several bioinformatic analyses,such as function classification and enrichment,subcellular location predication,metabolic pathway enrichment and protein−protein interaction networking,were conducted to characterize the functions of the identified sites and proteins.In total,1097 succinylation sites in 493 proteins were detected in patchouli plants,among which 466 succinylation sites in 241 proteins were repeatedly identified within three independent experiments.The functional characterization of these proteins indicated that the tricarboxylic acid(TCA)cycle,oxidative phosphorylation,photosynthesis processes,and amino acid biosynthesis may be regulated by lysine succinylation.In addition,these succinylated proteins showed a wide subcellular location distribution,although the chloroplast and cytoplasm were the top two preferred cellular components.Our study suggested the important role of lysine succinylation in patchouli plant physiology and biology and could serve as a useful reference for succinylation studies in other medicinal plants. | Xiaobing Wang Xiuzhen Chen Junren Li Xuanxuan Zhou Yanting Liu Liting Zhong Yun Tang Hai Zheng Jiyun Liu Ruoting Zhan Likai Chen | 2019 | Horticulture Research2019，6，1： | 2 |
| 5 | An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509显示文摘Marine microorganisms,especially marine fungi,have historically proven their value as a prolific source for structurally novel and pharmacologically active secondary metabolites(Deshmukh et al.,2018;Carroll et al.,2022).The corals constitute a dominant part of reefs with the highest biodiversity,and harbor highly diverse and abundant microbial symbionts in their tissue,skeleton,and mucus layer,with species-specific core members that are spatially partitioned across coral microhabitats(Wang WQ et al.,2022).The coral-associated fungi were very recently found to be vital producers of structurally diverse compounds,terpenes,alkaloids,peptides,aromatics,lactones,and steroids. | Miaoping LIN Zhenzhou TANG Jiaxi WANG Humu LU Chenwei WANG Yanting ZHANG Xinming LIU Chenghai GAO Yonghong LIU Xiaowei LUO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 1 |
| 6 | Effectiveness of contrast-enhanced ultrasound in the classification and emergency management of abdominal trauma显示文摘 | Faqin Lv Yanting Ning Xuan Zhou Yukun Luo Tong Liang Yongkang Nie Tanshi Li Jie Tang | 2014 | European Radiology2014，，： | 1 |
| 7 | New horizons for therapeutic applications of nanozymes in oral infection显示文摘As a category of nanomaterials with excellent catalytic efficiency,great substrate specificity,and highrecovery efficiency,nanozymes have attracted increasing attention in various biomedical applications.Currently,numbers of nanozyme-assisted strategies have been well developed for the theranostics ofvarious diseases by taking advantages of their multienzyme-like characteristics,low cost,and highstability.As the most prevalent oral diseases,oral infection poses a global hazard to human health,andcurrent therapeutic options are insufficient to resolve all the clinical issues.Based on their admirableactivity,nanozymes can be frequently employed in the identification and treatment of various oral infectious disorders.Herein,we provide a brief review focused on the classification of nanozymes,analysesof nanozyme-based antibacterial mechanism,research progress in oral bacterial control,and representative studies of nanozyme-assisted oral inflammatory management.Moreover,major challenges andpotential opportunities regarding the use of nanozymes in oral infectious diseases are also highlightedand discussed.This review not only summarizes the recent studies of nanozymes in oral infection butalso promotes the further development of enzyme-mimetic strategies towards various oral diseases. | Yanting Cai Yue Li Jin Zhang Nan Tang Xingfu Bao Zhen Liu | 2023 | Particuology2023，，9： | 0 |
| 8 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 9 | Compact wideband FSS-absorber-based low-RCS reflectarray antenna显示文摘This paper presents a method to realize compact broadband low-RCS ReflectArray(RA)antenna based on a Frequency Selective Surface(FSS)absorber and a reflective metasurface.Such an FSS absorber consists of a resistance-loaded lossy layer and an FSS layer,which is utilized to reach an absorption-transmission response.The bottom reflective metasurface works as a phase array,reshaping the quasi-sphere wave from the feeding antenna into the quasi-plane wave.As a demonstration,the low-RCS RA antenna is simulated,fabricated,and measured.The simulated and measured results show that the developed low-RCS RA antenna has an aperture efficiency of 42.7%and a gain of 25.4 dBi in the X band.In the meantime,it simultaneously reaches the 10 dB RCS reduction for the orthogonal polarizations at the S and C bands,corresponding to a fractal bandwidth of 120%.Specifically,the adopted patch-feeding antenna makes the RA antenna more compact than the horn-feed conventional ones.Furthermore,the proposed RA antenna uses a few layers of substrates,making it lower in cost and easier for fabrication.The proposed design may have potential application in integrated stealth communication systems. | Jianing YANG Yanting ZHANG Ming-Chun TANG Zhehao ZHANG Meijun QU | 2023 | Chinese Journal of Aeronautics2023，36，6： | 0 |
| 10 | RBM14 promotes DNA end resection during homologous recombination repair显示文摘DNA double-strand break(DSB)repair by homologous recombination(HR)is crucial for the maintenance of genome stability and integrity.In this study,we aim to identify novel RNA binding proteins(RBPs)involved in HR repair because little is known about RBP function in HR.For this purpose,we carry out pulldown assays using a synthetic ssDNA/dsDNA structure coated with replication protein A(RPA)to mimic resected DNA,a crucial intermediate in HR-mediated DSB repair.Using this approach,we identify RNA-binding motif protein 14(RBM14)as a potential binding partner.We further show that RBM14 interacts with an essential HR repair factor,CtIP.RBM14 is crucial for CtIP recruitment to DSB sites and for subsequent RPA coating and RAD51 replacement,facilitating efficient HR repair.Moreover,inhibition of RBM14 expression sensitizes cancer cells to X-ray irradiation.Together,our results demonstrate that RBM14 promotes DNA end resection to ensure HR repair and may serve as a potential target for cancer therapy. | Zheng Li Yanting Liao Chen Tang Linli Xu Bin Peng Xingzhi Xu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
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