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| 1 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 2 | L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction显示文摘Bone resorption requires the formation of complex, actin-rich cytoskeletal structures. During the early phase of sealing ring formation by osteoclasts, L-plastin regulates actin-bundling to form the nascent sealing zones(NSZ). Here, we show that L-plastin knockout mice produce osteoclasts that are deficient in the formation of NSZs, are hyporesorptive, and make superficial resorption pits in vitro. Transduction of TAT-fused full-length L-plastin peptide into osteoclasts from L-plastin knockout mice rescued the formation of nascent sealing zones and sealing rings in a time-dependent manner. This response was not observed with mutated full-length L-plastin(Ser-5 and-7 to Ala-5 and-7) peptide. In contrast to the observed defect in the NSZ, L-plastin deficiency did not affect podosome formation or adhesion of osteoclasts in vitro or in vivo. Histomorphometry analyses in 8-and 12-week-old female L-plastin knockout mice demonstrated a decrease in eroded perimeters and an increase in trabecular bone density, without a change in bone formation by osteoblasts. This decrease in eroded perimeters supports that osteoclast function is attenuated in L-plastin knockouts. Micro-CT analyses confirmed a marked increase in trabecular bone mass. In conclusion, female L-plastin knockout mice had increased trabecular bone density due to impaired bone resorption by osteoclasts. L-plastin could be a potential target for therapeutic interventions to treat trabecular bone loss. | Meenakshi AChellaiah Megan CMoorer Sunipa Majumdar Hanan Aljohani Sharon CMorley Vanessa Yingling Joseph PStains | 2020 | Bone Research2020，8，1： | 4 |
| 3 | Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China显示文摘Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants.Here,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known epicenter.SARS-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant.However,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization potency.The immune escape can be largely attributed to several critical spike mutations.These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants. | Qianyun Liu Qing Xiong Fanghua Mei Chengbao Ma Zhen Zhang Bing Hu Junqiang Xu Yongzhong Jiang Faxian Zhan Suhua Zhou Li Tao Xianying Chen Ming Guo Xin Wang Yaohui Fang Shu Shen Yingle Liu Fang Liu Li Zhou Ke Xu Changwen Ke Fei Deng Kun Cai Huan Yan Yu Chen Ke Lan | 2022 | The Innovation2022，3，1： | 3 |
| 4 | MimicCloudSim:An Environment for Modeling and Simulation of Mimic Cloud Service显示文摘In recent years,an increasing number of application services are deployed in the cloud.However,the cloud platform faces unknown security threats brought by its unknown vulnerabilities and backdoors.Many researchers have studied the Cyber Mimic Defense(CMD)technologies of the cloud services.However,there is a shortage of tools that enable researchers to evaluate their newly proposed cloud service CMD mechanisms,such as scheduling and decision mechanisms.To fill this gap,we propose MimicCloudSim as a mimic cloud service simulation system based on the basic functionalities of CloudSim.MimicCloudSim supports the simulation of dynamic heterogeneous redundancy(DHR)structure which is the core architecture of CMD technology,and provides an extensible interface to help researchers implement new scheduling and decision mechanisms.In this paper,we firstly describes the architecture and implementation of MimicCloudSim,and then discusses the simulation process.Finally,we demonstrate the capabilities of MimicCloudSim by using a decision mechanism.In addition,we tested the performance of MimicCloudSim,the conclusion shows that MimicCloudSim is highly scalable. | Liming Pu Jiangxing Wu Hailong Ma Yuhang Zhu Yingle Li | 2021 | China Communications2021，18，1： | 2 |
| 5 | The porcine cervical spine as a model of the human lumbar spine: an anatomical, geometric,and functional comparison 显示文摘 | Yingling VR Callaghan JP McGill SM | 1999 | J Spinal Disord1999，12，： | 1 |
| 6 | Magnetorheo- logical elastomers based on isobutylene isoprene rubber显示文摘 | Wang Yingling Hu Yuan Den Huaxia | 2006 | Polymer Engineering and Science2006，46，3： | 1 |
| 7 | Development of TGFb signalling inhibitors for cancer therapy显示文摘 | Yingling JM Blanchard KL Sawyer JS | 2004 | Nat Rev Drug Discov2004，12，3： | 1 |
| 8 | Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers显示文摘 | Tessema M Yingling CM Grimes MJ | 2012 | PLoS One2012，7，34： | 1 |
| 9 | Carcinogen- induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells 显示文摘 | Damiani L A Yingling C M Leng S | 2008 | Cancer Research2008，68，21： | 1 |
| 10 | EEG spectra in dyslexic and control boys during resting conditions 显示文摘 | Fein G Galin D Yingling CD | 1986 | Electroenceph Clin Neurophysiol1986，63，： | 1 |
| 11 | The determination of acrylam- ide in environmental and drinking waters by large-volume injec- tion-hydrophilic-interaction liquid chromatography and tandem mass spectrometry 显示文摘 | Backe WJ Yingling V Johnson T | 2014 | J of Chromatography A2014，1334，21： | 1 |
| 12 | Re expression of CXCL14,a common target for epigenetic silencing in lung cancer,induces tumor nccrosis显示文摘 | Tessema M Klingc DM Yingling CM | | 0，，： | 1 |
| 13 | The ecale-transfomlation of electromagnetic theory and its applications显示文摘 | Li Yingle Huang Jiying | 2005 | Chinese Physics2005，14，4： | 1 |
| 14 | Synthesis and ap- plication of crosslinking blue anthraquinone polyamine dye with high fixation 显示文摘 | Yingling Li Yanfeng Tang Shufen Zhang | 2007 | Textile Research Journal2007，77，9： | 1 |
| 15 | The porcine cervical spine as a model of the human lumbar spine: an anatomicai, geometric, and functional compadson 显示文摘 | Yingling VR Callaghan JF McGill SM | 1999 | J Spinal Disord1999，12，： | 1 |
| 16 | Fi nasteride targets prostate vascularity by inducing ap optosis and inhibiting cell adhesion of benign and ma lignant prostatecells显示文摘 | SUTTON M T YINGLING M VYAS A | 2006 | Prostate2006，66，： | 1 |
| 17 | The Effects Induced by Turbulence and Dust Storms on Millimeter Waves显示文摘 | Li Yingle Huang Jiying | 2002 | International Journal of Infrared and Millimeter Waves2002，23，3： | 1 |
| 18 | Role of 14-3-3 pro-teins in eukaryotic signaling and development 显示文摘 | Darling D L Yingling J Wynshaw Boris A | 2005 | Curr TopDev Biol2005，68，： | 1 |
| 19 | Rain Attenuation at Millimeter Wavelengths 显示文摘 | Li Yingle Huang Jiying | 2002 | International Journal of Infrared and Millimeter Waves2002，23，7： | 1 |
| 20 | Chitosansilica complex membranes from sulfonic acid functionalized silica nanoparticles for pervaporation dehydration of ethanol-water solutions显示文摘 | Liu Yingling Hsu Chihyuan Su Yuhuei | | 0，，01： | 1 |
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