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| 1 | Production of bioactive ginsenoside compound K in metabolically engineered yeast显示文摘 | Xing Yan Yun Fan Wei Wei Pingping Wang Qunfang Liu Yongjun Wei Lei Zhang Guoping Zhao Jianmin Yue Zhihua Zhou | 2014 | Cell Research2014，24，6： | 81 |
| 2 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 3 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 4 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 5 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 6 | Freeze-thaw Effects on Sorption/Desorption of Dissolved Organic Carbon in Wetland Soils显示文摘The effects of freeze-thaw cycles on sorption/desorption of dissolved organic carbon (DOC) in two wetland soils and one reclaimed wetland soil were investigated. DOC concentrations added were 0-600 mg/L. Laboratory incubations of sorption/desorption of DOC had been carried out at -15℃ for 10 h, and then at +5℃ for 13 h. Soil samples were refrozen and thawed subsequently for 5 cycles. Initial Mass model was used to describe sorption behavior of DOC. The results indicate that freeze-thaw cycles can significantly increase the sorption capacity of DOC and reduce the desorption capacity of DOC in the three soils. The freeze-thaw effects on desorption of DOC in soils increase with the increasing freeze-thaw cycles. The conversion of natural wetlands to soybean farmland can decrease the sorption capacity and increase the desorption capacity of DOC in soils. Global warming and reclamation may increase DOC release, and subsequently increase the loss of carbon and the emission of greenhouse gas. | YU Xiaofei ZHANG Yuxia ZHAO Hongmei LU Xianguo WANG Guoping | 2010 | Chinese Geographical Science2010，20，3： | 12 |
| 7 | Characteristic Analysis of UHVAC/DC Hybrid Power Grids and Construction of Power System Protection显示文摘Strong DC coupling with weak AC and large-scale renewable energy integration are the two significant characteristics of ultra-high-voltage AC/DC(UHVAC/DC)hybrid power grids in China.Strong coupling between AC and DC grids and the different integration performance of renewable energy sources have profoundly changed the stability characteristics of the power system.The traditional stability control system is inadequate for the stability control of UHVAC/DC power grids.This paper analyzes the requirements for constructing an integrated defense system in a UHVAC/DC hybrid power grid(i.e.power system protection).The definition,connotation,and designing principles of power system protection are put forward.The relationship between the power system protection and the traditional three-defense lines is investigated.The design principles,general hardware structure and main functions of a power system protection are presented.Key problems and technologies are specified in the construction of the power system protection. | Yinbiao Shu Guoping Chen Zhao Yu Jianyun Zhang Chao Wang Chao Zheng | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 11 |
| 8 | Water mass of the northward throughflow in the Bering Strait in the summer of 2003显示文摘The temperature and salinity data obtained by the Chinese national arctic research expedition (CHINARE2003) are used to study the water structure in the Bering Strait and ambient regions. Four water masses appeared in the research region: the intermediate Bering Sea water mass (IBWM), the Alaska coastal water (ACW), the Anadyr water (AW) and the Bering shelf water (BSW). The AW originates from the IBWM, but the upper layer water has been greatly altered. In the cruise on 28/29 July 2003, there were only the BSW and ACW in a section across the Bering Strait (BS section), but in the September 12/13 cruise, the AW, BSW and ACW flowed parallelly into the Bering Strait. The upper waters of these water masses were all altered due to ice melting, runoff, solar radiation, and wind mixing. The waters in the central and northern parts of Bering Strait stratified by two uniform layers,were expressed as the typical feature of the water masses originating from the pacific. A two-layer structure also dominated the vertical stratification in most part of the Chukchi Sea. An obvious subseasonal variation was observed in the BS section, which caused varying transportation of fresh water, heat, and substance, and produced a long-term and extensive impact on the Arctic Ocean. | ZHAO Jinping SHI Jiuxin GAO Guoping JIAO Yutian ZHANG Hongxin | 2006 | Acta Oceanologica Sinica2006，25，2： | 10 |
| 9 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 10 | Mechanisms involved in antineuralgic effects of Paeonia Lactiflora: prediction based on network pharmacology显示文摘目的:白芍的镇痛作用已被广泛应用于中医临床,但对其潜在机制知之甚少.本研究旨在从网络药理学的角度阐明其有效成分和镇痛机制.方法:通过中药系统药理学分析平台(TCMSP)筛选出其可能的活性成分及CAS.从Pubchem 中获得其SMILES,并通过在Swiss Target Prediction 数据库中反向对接获得潜在的靶点.从GeenCards 数据库中提取疼痛相关分子,采用韦恩图筛选出芍药治疗疼痛的预测靶点.机制分析采用String 构建蛋白-蛋白相互作用,运用DAVID 平台进行靶点GO 功能富集和KEGG 信号通路富集.结果:通过GO 和KEGG 分析我们发现疼痛相关的信号通路主要涉及血清素能突触、钙信号通路、调控TRP 通道的炎症介质.利用基于网络的系统生物学和分子对接分析,我们预测了白芍中的11 种活性成分和97 个潜在的治疗靶标.PRKCA、CASP3、ALOX15、SLC6A4、PRKCG、ALOX5、PRKCB、ALOX12、 EGFR、ADRB2、RYR3、RYR1、NOS2、PTAFR、PRKCQ、PRKCD 等基因参与了白芍的镇痛作用.结论:白芍可通过调节TRP 通道炎症介质、钙信号通路和5-羟色胺受体减轻疼痛.PRKCA、PRKCB、PRKCD、 PRKCQ 和PRKCG 可能是疼痛治疗的新靶标. | Di Zhang Shengsuo Ma Jianxin Sun Bing Yang Haoming Lin Meijing Xie Meina Huang Guoping Zhao | 2019 | TMR Clinical Research2019，2，2： | 8 |
| 11 | Effect of Berm Width and Elevation on Irregular Wave Run-Up显示文摘This paper discusses the effect of berm width and elevation of composite slope on irregular wave run-up. Based on the data obtained from model tests, the formula and distribution of irregular wave run-up on composite slope are derived. The changing of wind speed, width and elevation of the berm are considered comprehensively. The wave run-up with various exceedance probability can be es-timated utilizing the distribution curves of irregular wave run-up. | Chen Guoping , Yu Kuang-ming and Zhang Jiachang Assistant Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, NanjingProf. and Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing | 1991 | China Ocean Engineering1991，6，4： | 7 |
| 12 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 13 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 14 | Reversible 3D optical data storage and information encryption in photo-modulated transparent glass medium显示文摘Transparent glass has been identified as a vital medium for three-dimensional(3D)optical information storage and multi-level encryption.However,it has remained a challenge for directly writing 3D patterning inside a transparent glass using semiconductor blue laser instead of high-cost femtosecond laser.Here,we demonstrate that rare earth ions doped transparent glass can be used as 3D optical information storage and data encryption medium based on their reversible transmittance and photoluminescence manipulation.The color of tungsten phosphate glass doped with rare earth ions change reversibly from light yellow to blue upon alternating 473 nm laser illumination and temperature stimulation,resulting in the reversible luminescence modulation.The information data could be repeatedly written and erased in arbitrary 3D space of transparent glass,not only showing the ability of the excellent reproducibility and storage capacity,but also opening opportunities in information security.The present work expands the application fields of luminescent glass,and it is conducive to develop a novel 3D data storage and information encryption media. | Zhen Hu Xiongjian Huang Zhengwen Yang Jianbei Qiu Zhiguo Song Junying Zhang Guoping Dong | 2021 | Light(Science & Applications)2021，10，8： | 6 |
| 15 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 16 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 17 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 18 | Cloning and characterization of three cheB genes in Leptospira interrogans显示文摘活动性和趋化性系统为 leptospires 的毒力是批评的。有在 leptospires 定位的通常认为的趋化性相当或相同的事物的多重拷贝大染色体。从螺旋体 interrogans 紧张 Lai 的 CheB1 和 CheB3 被预言有一个全球象 CheB 一样领域,但是 CheB2 被预言仅仅有一个 C 终端受动器领域。以便验证三通常认为的 cheB 基因的功能,他们被克隆进 pQE31 向量然后分别地,在野类型的 Escherichia coli 紧张 RP437 和 cheB 有缺陷者紧张 RP4972 表示了。聚集的试金的结果和 CheB1 的预言的第三的结构和 L 的 CheB3。interrogans 紧张 Lai 建议一个 N 终端规章的领域的缺席可以是原因之一让 CheB2 的失败补充 E。coli cheB 异种。而且, CheB2 在 leptospires 的相互作用网络完全连接到 CheR1 和 CheR3。一起拿,这些结果显示 CheB2 不能独自工作,并且在某些生理的条件下面,工作可以要求 CheB3 和 CheR1。趋化性基因相当或相同的事物的多重拷贝的存在建议了那 L。interrogans 紧张 Lai 可能有一条更复杂的化学感应的小径。 | Ke Dong Qingtian Li Chang Liu Yunyi Zhang Guoping Zhao Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 5 |
| 19 | Static Frame Model Validation with Small Samples Solution Using Improved Kernel Density Estimation and Confidence Level Method显示文摘An improved method using kernel density estimation (KDE) and confidence level is presented for model validation with small samples. Decision making is a challenging problem because of input uncertainty and only small samples can be used due to the high costs of experimental measurements. However, model validation provides more confidence for decision makers when improving prediction accuracy at the same time. The confidence level method is introduced and the optimum sample variance is determined using a new method in kernel density estimation to increase the credibility of model validation. As a numerical example, the static frame model validation challenge problem presented by Sandia National Laboratories has been chosen. The optimum bandwidth is selected in kernel density estimation in order to build the probability model based on the calibration data. The model assessment is achieved using validation and accreditation experimental data respectively based on the probability model. Finally, the target structure prediction is performed using validated model, which are consistent with the results obtained by other researchers. The results demonstrate that the method using the improved confidence level and kernel density estimation is an effective approach to solve the model validation problem with small samples. | ZHANG Baoqiang CHEN Guoping GUO Qintao | 2012 | Chinese Journal of Aeronautics2012，25，6： | 5 |
| 20 | Design and physical model experiment of an attitude adjustment device for a crawler tractor in hilly and mountainous regions显示文摘To address the problems of difficult leveling and poor stability of hill crawler tractors,an attitude adjustment device based on a parallel four-bar mechanism was designed,and the mechanical reasons for the sideslip instability of hill crawler tractors were analyzed.On this basis,a posture adjustment mechanism based on a parallel four-bar mechanism was proposed,and the structure of the complete attitude adjustment device was designed.To ensure that this device meets the strength requirements during operation,a mechanical analysis of the key components(active rocker and slave rocker)was carried out to accommodate the load during leveling.Based on ANSYS software,a finite element simulation analysis was used to determine the maximum stress position of the active and slave rockers.Finally,to verify the accuracy of the above simulation analysis results and determine the influence rules of the lateral slope angle,longitudinal slope angle and loading quality on the abovementioned maximum stress,a physical model test bench of the attitude adjustment device was built.An orthogonal regression experiment was carried out with the maximum stresses of the active and slave rockers as the test indices.The experimental data were analyzed by Design-Expert 10 software,and the results show that the order of the primary and secondary factors influencing the maximum stress of the active rocker was the loading mass,lateral slope angle and longitudinal slope angle.The order of the factors influencing the maximum stress of the slave rocker was the longitudinal slope angle,lateral slope angle and loading mass.The active and slave rockers meet the strength requirements.This work provides technical support for the production of hill crawler tractor physical prototypes. | Jingbin Sun Chong Meng Yazhou Zhang Guoping Chu Yanjie Zhang Fuzeng Yang Zhijie Liu | 2020 | Information Processing in Agriculture2020，7，3： | 5 |
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