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| 1 | Targeted therapies in breast cancer:New challenges to fight against resistance显示文摘Breast cancer is the most common type of cancer found in women and today represents a significant challenge to public health. With the latest breakthroughs in molecular biology and immunotherapy, very specific targeted therapies have been tailored to the specific pathophysiology of different types of breast cancers. These recent developments have contributed to a more efficient and specific treatment protocol in breast cancer patients. However, the main challenge to be further investigated still remains the emergence of therapeutic resistance mechanisms, which develop soon after the onset of therapy and need urgent attention and further elucidation. What are the recent emerging molecular resistance mechanisms in breast cancer targeted therapy and what are the best strategies to apply in order to circumvent this important obstacle? The main scope of this review is to provide a thorough update of recent developments in the field and discuss future prospects for preventing resistance mechanisms in the quest to increase overall survival of patients suffering from the disease. | Viviana Masoud Gilles Pagès | 2017 | World Journal of Clinical Oncology2017，8，2： | 13 |
| 2 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 3 | FIT阳性结直肠癌筛查对象的结肠胶囊内窥镜检查与CT结肠成像检查对比:一项前瞻性随机试验--VICOCA研究显示文摘背景:结肠胶囊内窥镜检查(colon capsule endoscopy,CCE)和CT结肠成像(CT colonography,CTC)是用于结直肠癌(CRC)筛查的微创技术。我们的目的在于比较CCE和CTC在CRC筛查发现粪便免疫化学试验(faecal immunochemicaltest,FIT)阳性的受试者中识别结直肠肿瘤患者的效能。主要研究结果是CCE和CTC检出肿瘤性病变效能的比较。方法:VICOCA研究是一项于2014年3月至2016年5月进行的前瞻性、单中心随机试验。在进行结肠镜检查之前,共向662人提出检查建议,其中349人被随机分入CCE组或CTC组。内镜医师并未知晓CCE和CTC检查的结果。结果:共349人纳入分组,其中CCE组173人、CTC组176人。共290人同意参加该研究,其中CCE组147人、CTC组143人。在意向筛查分析中,CCE组检出结直肠肿瘤的敏感度、特异度、阳性预测值和阴性预测值分别为98.1%、76.6%、93.7%和92.0%,CTC组相应分别为64.9%、95.7%、96.8%和57.7%。在检出显见的肿瘤性病变方面,CCE组和CTC组的敏感度分别为96.1%和79.3%。CCE组对晚期结直肠肿瘤的检出率有相比CTC组更高的趋势(分别为100%和93.1%,RR=1.07,P=0.08)。CCE组和CTC组均识别出所有癌症患者。CCE组检出存在任一肿瘤性病变患者的比例高于CTC组(分别为98.6%和81.0%,RR=1.22,P=0.002)。结论:虽然两种技术在识别晚期结直肠肿瘤患者方面的效能相近,但CCE检出任一肿瘤性病变的敏感度更高。 | 佟伟华 GONZáLEZ-SUáREZ B PAGéS M ARAUJO I K | 2020 | 结直肠肛门外科2020，26，6： | 4 |
| 4 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 5 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 6 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 7 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 2 |
| 8 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 9 | A new fluorimetric assay for cytotoxity measurements in vitro 显示文摘 | Pag B Page M Noe I C | 1993 | International Journal of Oncology1993，3，： | 1 |
| 10 | Mean square convergence of consensus algorithms in random WSNs显示文摘 | Pereira S Pag′es-Zamora A | 2010 | IEEE Trans on Signal Processing2010，58，5： | 1 |
| 11 | Mechanism of Flecainide?s Antiarrhythmic Action in Experimental Atrial Fibrillation显示文摘 | Zhiguo Wang Pierre Pagé Stanley Nattel | 1992 | Circulation Research1992，，2： | 1 |
| 12 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 13 | The Immune Microenvironment of Human Tumors: General Significance and Clinical Impact显示文摘 | Wolf-Herman Fridman Marie-Caroline Dieu-Nosjean Franck Pagès Isabelle Cremer Diane Damotte Catherine Sautès-Fridman Jér?me Galon | 2013 | Cancer Microenvironment2013，，2： | 1 |
| 14 | Process performance and polyphosphate-accumulating organism : glycogen-accumulating organism communities in an anaerobic/anoxic/oxic system operated with different carbon sources显示文摘 | GIRARD L ENCINA PAG RODRIGUEZ E R | 2012 | Water Environ Res2012，84，4： | 1 |
| 15 | Surface-induced photorefractive-like effect in pure liquid crystals 显示文摘 | PAG LIUSI P CIPPARRONE G | 2002 | Appl Phys Lett2002，80，2： | 1 |
| 16 | Selective transport of Li - Na and Li - K binary systems across a cation exchange membrane under an electric field显示文摘 | Gladys Paz T Cruz Pag - asa D Gaspillo Katsuroku Takahashi | 2000 | Separation and Purification Technology2000，19，12： | 1 |
| 17 | The use of fluorescein labelled dextrans in investigation of aqueous humor outflow in the rabbit 显示文摘 | Monro PAG | 1976 | Exp Eye Res1976，23，： | 1 |
| 18 | Protective effect of the inhibition of the renin-angiotensin system on aging显示文摘 | Basso N Pag lia N Stella I | 2005 | Regul Pept2005，128，： | 1 |
| 19 | Modelling the influence of assimilate availability on root growth and architecture显示文摘 | THALER P PAGS L | 1998 | Plant and Soi11998，201，： | 1 |
| 20 | Two different Em-like genes are expressed in Arabidopsis thaliana seeds during maturation显示文摘 | Pascale Gaubier Monique Raynal Gillian Hull Gordon M. Huestis Fran?oise Grellet César Arenas Montserrat Pagès Michel Delseny | 1993 | MGG Molecular & General Genetics1993，，3： | 1 |
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