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| 1 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 2 | Process performance and polyphosphate-accumulating organism : glycogen-accumulating organism communities in an anaerobic/anoxic/oxic system operated with different carbon sources显示文摘 | GIRARD L ENCINA PAG RODRIGUEZ E R | 2012 | Water Environ Res2012，84，4： | 1 |
| 3 | Modelling the influence of assimilate availability on root growth and architecture显示文摘 | THALER P PAGS L | 1998 | Plant and Soi11998，201，： | 1 |
| 4 | A new fluorimetric assay for cytotoxity measurements in vitro显示文摘 | Pagé B Pagé M Noèl C | 1993 | International Journal of Oncology1993，3，： | 1 |
| 5 | The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis显示文摘 | Bost F Aouadi M Caron L Even P Belmonte N Prot M Dani C Hofman P Pagès G P | | 0，，02： | 1 |
| 6 | Induction of hypoxia-inducible factor-1a by transcriptional and translational mechanisms显示文摘 | Pagé E L Robitaille G A Pouysségur J | 2002 | J Biol Chem2002，277，48： | 1 |
| 7 | Effect of species,root branching order and season on the root traits of 13 perennial grass species 显示文摘 | Picon-Cochard C Pilon R Tarroux E Pagès L Robertson J Dawson L | 2012 | Plant Soil2012，353，12： | 1 |
| 8 | Links between root developmental traits and foraging performance显示文摘 | Pagès L | 2011 | Plant Cell and Environment2011，34，： | 1 |
| 9 | Design,synthesis,and biological activities of new thienopyrimidinesas selective type 4 phosphodiesterase inhibitors显示文摘 | Crespo M I Pagès L Vega A | 1998 | JMed Chem1998，41，21： | 1 |
| 10 | Molecularly imprinted monodisperse microspheres for competitive radioaasay显示文摘 | Ye L Cormack PAG Mosbach K | | 0，，2： | 1 |
| 11 | A Simulation model of the three-dimensional architecture of the maize root system显示文摘 | Pagès L Jordan M O Picard D | 1989 | Plant Soil1989，，119： | 1 |
| 12 | Effects of antiarrhythmic drug therapy on atrioventricular nodal function during atrial fibrillation in humans显示文摘 | Mangin L Vinet A Pag~ P | 2005 | Europace2005，，： | 1 |
| 13 | Inc rea s edinflammatory gene expression in ABC transporter-deficientmacrophages:f ree cholesterol accumulat ion,increasedsignaling via toll-like receptors,and neutrophil infiltration ofatherosclerotic lesions显示文摘 | Yv an-Cha r v e t L We l ch C Pag l e r TA e t al | 2009 | Circulation2009，118，18： | 1 |
| 14 | An improved mouse model for endometriosis allows noninvasive assessment of lesion implantation and development显示文摘 | Fortin M Lépine M Pagé M | 2003 | Ferfil Steril2003，80，2： | 1 |
| 15 | Induction of hypoxia-inducible factor-1 α by transcriptional and translational mechanisms显示文摘 | Pagé E L Robitaille G A Pouysségur J | | 0，，50： | 1 |
| 16 | Molecular basis of macrolide resistance in Campylobacter:role of efflux pumps and target mutations显示文摘 | Mamelli L Prouzet-Maulé on V Pagè s JM | | 0，，3： | 1 |
| 17 | Root apical diameter and root elongation rate of rubber seed]ings(Hevea brasiliensis)show parallel responses to photoassimilate availability显示文摘 | Thaler P Pagès L | | 0，，2： | 1 |
| 18 | Root system architecture:Opportunities and constraints for genetic improvement of crops显示文摘 | de Dorlodot S Forster B Pagès L | | 0，，10： | 1 |
| 19 | Molecular basis of macrolide resistance in Campylobacter:role of efflux pumps and target mutations显示文摘 | Mamelli L Prouzet-Maulèon V Pagès J M | 2005 | Journal of Antimicrobial Chemotherapy2005，56，： | 1 |
| 20 | Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms显示文摘 | Pagé Eeneviève A | 2002 | J Biol Chem2002，277，48： | 1 |
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