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| 1 | 胰腺实性-假乳头状肿瘤显示文摘 | Geers C Pierre M Jean-Francois G 刘飞飞(摘译) 张仁亚(摘译) | 2006 | 临床与实验病理学杂志2006，22，6： | 17 |
| 2 | Experimental evidence of obesity as a risk factor for severe acute pancreatitis显示文摘The incidence of acute pancreatitis,an inflammation of the pancreas,is increasing worldwide.Pancreatic injury is mild in 80%-90% of patients who recover without complications.The remaining patients may develop a severe disease with local complications such as acinar cell necrosis,abscess and remote organ injury including lung injury.The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications.For that purpose,multiple clinical scale scores have been applied to patients with acute pancreatitis.Recently,a new problem has emerged:the increased severity of the disease in obese patients.However,the mechanisms by which obesity increases the severity of acute pancreatitis are unclear.Several hypotheses have been suggested:(1) obese patients have an increased inflammation within the pancreas;(2) obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located;(3) increase in both peri-and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients;(4) hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxification of inflammatory mediators;and(5) ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury.Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines lep-tin and adiponectin.Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity.It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severity of acute pancreatitis. | Jean-Louis Frossard Pierre Lescuyer Catherine M Pastor | 2009 | World Journal of Gastroenterology2009，15，42： | 14 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 5 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 6 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 7 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 8 | Th17 and regulatory T cell balance in autoimmune and inflammatory diseases显示文摘 | Mélissa Noack Pierre Miossec | 2013 | Autoimmunity Reviews2013，，： | 2 |
| 9 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | 2005 (9472)2005，，9472： | 2 |
| 10 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 11 | Degradation Mechanisms of Vertical Cavity Surface Emitting Lasers, Quantum Electronics显示文摘 | Michael C Y Robert W H Pierre M P | 1996 | IEEE Journal1996，32，： | 2 |
| 12 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9ehwvkcubk0owc66pou.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 13 | Predicted Effects of Treatment for HCV Infection Vary Among European Countries显示文摘 | Sylvie Deuffic–Burban Pierre Deltenre Maria Buti Tommaso Stroffolini Julie Parkes Nikolai Mühlberger Uwe Siebert Christophe Moreno Angelos Hatzakis William Rosenberg Stefan Zeuzem Philippe Mathurin | 2012 | Gastroenterology2012，，4： | 2 |
| 14 | Impact of chronic Helicobacter pylori infection on Alzheimer’s disease: preliminary results显示文摘 | Claire Roubaud-Baudron Pierre Krolak-Salmon Isabelle Quadrio Francis Mégraud Nathalie Salles | 2012 | Neurobiology of Aging2012，，5： | 2 |
| 15 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 2 |
| 16 | Rennet coagulation of skim milk and curd drainage: effect of pH, casein concentration, ionic strength and heat treatment 显示文摘 | Daviau C Famelart M H Pierre A | 2000 | Lait2000，80，4： | 1 |
| 17 | Elastic effects on surface physics显示文摘 | PIERRE M ARDRES S | 2004 | Surf Sci Rep2004，54，5： | 1 |
| 18 | A high-efficiency CMOS voltage doubler显示文摘 | Pierre F Philippe D Declercq M J | 1998 | IEEE Journal of Solid-State Circuits1998，33，3： | 1 |
| 19 | Free vibrations of beams with a single-edge crack显示文摘 | SHEN M PIERRE C | 1994 | J Sound Vib1994，170，： | 1 |
| 20 | Agircuhural sector and industrial agglomeration 显示文摘 | Pierre M Picard Zeng Dao-Zhi | 2005 | Journal of Development Economics2005，，77： | 1 |
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