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| 1 | IL-17在局部及全身的致关节炎作用:从发现到靶向治疗显示文摘近年IL-17的重要作用逐渐被全面认识。IL-17主要由辅助性T细胞17(Th17)产生。IL-17家族中有6个成员:IL-A、IL-B、IL-C、IL-D、IL-E(又称IL-25)、IL-F。它可以直接或间接诱导多种细胞因子、炎性因子和抗微生物蛋白介导自身免疫和慢性感染。IL-17在许多自身免疫疾病患者和肿瘤患者中高表达。它涉及多种炎症性疾病的病理过程,包括银屑病、银屑病关节炎、类风湿关节炎、强直性脊柱炎,并在骨丢失和骨形成中起重要作用。目前,多项研究结果为IL-17靶向治疗人类疾病提供了强有力的理论基础。IL-17靶向治疗的相关研究聚焦于控制慢性炎症相关的损伤和疼痛。2015年第一批IL-17靶向抗体被批准用于银屑病的治疗。目前越来越多直接或间接作用于IL-17信号通路的IL-17靶向药物在实验室研究后被用于临床试验。该文综述了IL-17从发现到明确局部和全身致关节炎作用的整个过程,呈现了一个很好的从基础到临床的'转化医学'案例。 | 莫颖倩 毕瑜斐 戴冽 Pierre Miossec | 2018 | 新医学2018，49，7： | 11 |
| 2 | Local and systemic effects of IL-17 in joint inflammation:a historical perspective from discovery to targeting显示文摘The role of IL-17 in many inflammatory and autoimmune diseases is now well established,with three currently registered anti-IL-17-targeted therapies.This story has taken place over a period of 20 years and led to the demonstration that a T cell product could regulate,and often amplify,the inflammatory response.The first results described the contribution of IL-17 to local features in arthritis.Then,understanding was extended to its systemic effects,with a focus on cardiovascular aspects.This review provides a historical perspective of these discoveries focused on arthritis,which started in 1995,followed 10 years later by the description of Th17 cells.Today,IL-17 inhibitors for three chronic inflammatory diseases have been registered.More options are now being tested in ongoing and future clinical trials.Inhibitors of IL-17 family members and Th17 cells ranging from antibodies to small molecules are under active development.The identification of patients with IL-17-driven disease is a key target for the improved selection of patients expected to have a strongly positive response. | Pierre Miossec | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 3 | Th17 and regulatory T cell balance in autoimmune and inflammatory diseases显示文摘 | Mélissa Noack Pierre Miossec | 2013 | Autoimmunity Reviews2013，，： | 2 |
| 4 | Interleukin-17 and Thl cells: From adult to juve- nile arthritis--Now it is serious显示文摘 | Pierre Miossec | 2011 | Arthritis & Rheumatism2011，63，8： | 1 |
| 5 | Interleukin-17 and type 17 helper T cells显示文摘 | Miossec P Korn T Kuchroo VK | 2009 | N Engl J Med2009，361，9： | 1 |
| 6 | Alien species alert: Crassostrea gigas (Pacific oyster) 显示文摘 | Miossec L Le Deuff R M Goulletquer P | 2009 | ICES Cooperative Research Report2009，299，： | 1 |
| 7 | Interleukin-17 and type 17 helper T cells显示文摘 | Miossec P Korn T Kuchroo VK | 2009 | N Engl J Med2009，361，9： | 1 |
| 8 | Inteleukin-17 and type 17 helper T cells显示文摘 | Miossec P Korn T Kuchroo VK | | 0，，13： | 1 |
| 9 | Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy显示文摘 | Miossec P | 2003 | Arthritis Rheum2003，48，3： | 1 |
| 10 | Interleukin 17 and type 17 helper Tcells显示文摘 | MIOSSEC P KORN T KUCHROO V K | 2009 | N EnglJ Med2009，361，9： | 1 |
| 11 | Anatomic localization of immature and mature dentritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium显示文摘 | Page G Lebecque S Miossec P | 2002 | J Immunol2002，168，10： | 1 |
| 12 | Analysis of interleukin- 6,interleukin - 10 and leukemia inhibitory factor (LIF) production by peripheral blood cells from patients with systemic lupus erythematosus identifies LIF as a potential marker of disease activity显示文摘 | Viallard JF Taupin JL Miossec V | 1999 | Eur Cytokine Netw1999，10，1： | 1 |
| 13 | Effects of interleukin (IL) -17 A and IL-17 F in human rheumatoid arthritis synoviocytes显示文摘 | Hot A Miossec P | 2011 | Ann Rheum Dis2011，70，5： | 1 |
| 14 | Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL lbeta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes显示文摘 | Granet C Maslinski W Miossec P | 2004 | Arthr Res Ther2004，6，3： | 1 |
| 15 | Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression显示文摘 | Page G Miossec P | 2004 | J Pathol2004，204，1： | 1 |
| 16 | Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synovioeytes显示文摘 | Hot A Miossec P | 2011 | Ann Rheum Dis2011，70，5： | 1 |
| 17 | IL-17 is produced by some pro-inflammatory Th1/Th0 cells but not by Th2 cells 显示文摘 | Aarvak T Chabaud M Miossec P | 1999 | J Immunol1999，162，3： | 1 |
| 18 | Retrospective analysis of neonatal data in a monocentric cohort of 170 newborns of polydrug-using mothers,le-de-France,1999-2008显示文摘 | Lejeune C Genest L Miossec E | | 0，，02： | 1 |
| 19 | Physiopathology of haemophilic arthropathy显示文摘 | Lafeber FP Miossec P Valentino LA | | 0，，4： | 1 |
| 20 | Cytokines and autoimmune diseases from the control of autoimmune diseases with anti-cytokine treat- ment to the induction of autoimmunity with cytokine treat- ment 显示文摘 | Miossec P | 2007 | Methods Pharmacol Toxicol2007，12，7： | 1 |
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