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| 1 | 光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素显示文摘克氏综合征和Y染色体微缺失是过去针对男性不育症仅有的两项基因检测分析技术。北非男性经常出现两种罕见的畸形精子症:大头和圆头精子畸形,推荐进行AURKC和DPYl9L2基因检测。对阿尔及利亚男性不育患者进行以上基因检测,评估两种畸形精子症的患病率,并与克氏综合征和Y染色体微缺失的频率进行比较。我们对阿尔及利亚君士坦丁市的IbnRochd医院辅助生殖中心进行不育症咨询的599名患者进行了回顾性研究,其中404人存在精液参数异常现象。14人和7人分别患有典型的大头精子畸形或圆头精子畸形,进而对这些患者进行了AURKC和DPYl9L2基因分析显示,11名大头精子畸形患者存在4URKC基因突变(79%),相当于所有精液异常人群的2.7%。而5名圆头精子畸形患者,相当于1.2%的不育症患者,均存在DPYl9L2基因缺失。通过比较,我们预测该人群中克氏综合症和Y染色体微缺失的患病率分别是1.6%和0.23%。我们的研究表明AURKC基因突变较克氏综合症更常见,它是导致北非男性不育的主要遗传因素。此外,本文也预测了AURKC和DP"觋2基因缺陷发生率分别是Y染色体微缺失发生率的10倍和5倍。 | Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 2 | 珠江口EwE模型功能组划分研究显示文摘对珠江口水域生态系统进行EwE模型功能组划分研究。在总结功能组划分方法的基础上,对珠江口水域生态系统进行了功能组划分。功能组的划分结果基本可以覆盖珠江口水域生态系统的能量流动过程,为进一步构建珠江口生态系统的营养模型,研究珠江口渔业发展变化,促进EwE软件在我国的推广应用具有重要意义。 | 刘玉 隋丽杰 段丽杰 路宁宁 李适宇 PIERRE F | 2008 | 海洋环境科学2008，27，5： | 3 |
| 3 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 4 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 5 | Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices显示文摘瞄准:为了为生男性征的测量发现一个在试管内系统,芙蓉 macranthus (锦葵科) 和 Basella 白长袍的不同摘录完成一(Basellaceae ) 。方法:从片在二媒介,包含0.5%牛的血清白蛋白( BSA )的任何一个 Krebs-Henseleit 缓冲区或 Dubecco 孵化了的睾丸的睾丸激素的生产是修改的鹰的 medium-F12 火腿滋养的混合( DME/Ham F12 ),在5%的混合物下面,在95%空中的 CO2 也当面被决定或加 Basella 白长袍的余因子和芙蓉 macranthus 的缺席一( HMBA )摘录。结果:睾丸激素生产在在响应余因子(49%) 和水浸膏中等的 DME/Ham F12 孵化的睾丸片被增加(34%-60% 根据冲淡) 。在一样的大气的条件下面,没有到在 Krebs-Henseleit 的刺激缓冲包含 0.5% BSA 的余因子或 HMBA 摘录的睾丸片的积极反应。在与 HMBA 的效果有关的进一步的调查, DME/Ham F12 媒介被使用。从在试管内测试获得的结果证明这项活动在二氯甲烷和甲醇主要是在场的,自从这些摘录由睾丸片在睾丸激素生产导致了增加。结论:睾丸片系统是合适的被用于植物的生男性征的简历有功成分的隔离的进一步的在试管内调查。 | Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau | 2006 | Asian Journal of Andrology2006，8，1： | 2 |
| 6 | From azoospermia to macrozoospermia,a phenotypic continuum due to mutations in the ZMYND15 gene显示文摘Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing(WES),many genes have now been linked to severe sperm defects.A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C(AURKC)gene.Here,we studied a subject with a severe oligozoospermia and a phenotypic diagnosis of macrozoospermia.AURKC analysis did not reveal any deleterious variant.WES was then initiated which permitted to identify a homozygous loss of function variant in the zinc finger MYND-type containing 15(ZMYND15)gene.ZMYND15 has been described to serve as a switch for haploid gene expression,and mice devoid of ZMYND15 were shown to be sterile due to nonobstructive azoospermia(NOA).In man,ZMYND15 has been associated with NOA and severe oligozoospermia.We confirm here that the presence of a bi-allelic ZMYND15 variant induces a severe oligozoospermia.In addition,we show that severe oligozoospermia can be associated macrozoospermia,and that a phenotypic misdiagnosis is possible,potentially delaying the genetic diagnosis.In conclusion,genetic defects in ZMYND15 can induce complete NOA or severe oligozoospermia associated with a very severe teratozoospermia.In our experience,severe oligozoospermia is often associated with severe teratozoospermia and can sometimes be misinterpreted as macrozoospermia or globozoospermia.In these instances,specific AURKC or dpy-19 like 2(DPY19L2)diagnosis is usually negative and we recommend the direct use of a pan-genomic techniques such as WES. | Zine-Eddine Kherraf Caroline Cazin Florence Lestrade Jana Muronova Charles Coutton Christophe Arnoult Nicolas Thierry-Mieg Pierre F Ray | 2022 | Asian Journal of Andrology2022，24，3： | 2 |
| 7 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | Pierre Le-Clech Vicki Chen Tony A G F | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 8 | A high-efficiency CMOS voltage doubler显示文摘 | Pierre F Philippe D Declercq M J | 1998 | IEEE Journal of Solid-State Circuits1998，33，3： | 1 |
| 9 | Estimating EGARCH-M Models:Science or Art?显示文摘 | Eileen F Pierre S T | 1998 | The Quarterly Revi-ew of Economics and Finance1998，38，： | 1 |
| 10 | Complications of laparoscopy in gynecology显示文摘 | Chapron C Pierre F Querleu D | 2001 | Gynecol Obstet Fertil2001，29，9： | 1 |
| 11 | Arterial emboliz-ation for massive hematuria following transurethral prostatectomy显示文摘 | Michel F Dubruille T Jean- Pierre C | 2002 | J Urol2002，168，： | 1 |
| 12 | Ce 3d XPS study of composite CexMn1-xO2-y wet oxidation catalysts显示文摘 | Larachi F Pierre J Adnot A Bernis A | | 0，，1： | 1 |
| 13 | Stabilization of second order evolution equations by unbounded nonlinear feed-back显示文摘 | CONRAD F PIERRE M | 1994 | Ann de 1''I H P analyse non lineaire1994，11，： | 1 |
| 14 | Cell - cycle - dependent expression of transforming growth factor β type Ⅰ receptor correlates with differential proliferative effects if TGF - β1 in articular chondrocytes显示文摘 | Nathalie F Jean - Pierre P | 1998 | Experimental cell research1998，243，： | 1 |
| 15 | Pulse pressure is an independent determinant of renal function decline during treatment of essential hypertension显示文摘 | Pierre F Safar ME Cailar GD | 2007 | J Hypertension2007，25，9： | 1 |
| 16 | Acute plateletpheresis and aprotinin reduces the need for blood transfusion following Ross operation 显示文摘 | Al-Rashidi F Bhat M Pierre L | 2007 | Interact Cardiovasc Thorae Surg2007，6，5： | 1 |
| 17 | Muscle fiber area distribution of musculus uvulae in obstructive sleep apnea and non-apneic snorers显示文摘 | SEARIEAS F SIMONEAU J ST PIERRE S | 2000 | Int J Obesity2000，24，： | 1 |
| 18 | Polarization properties of birefringenee gratings显示文摘 | Pierre P F Doueen M L | 1995 | Optik1995，100，： | 1 |
| 19 | RnKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose 显示文摘 | RANDOUX M DAVIERE J M JEAUFFRE J THOUROUDE T PIERRE S TOUALBIA Y PERROTTE J REYNO1RD J P JAMMES M J HIBRAND-SAINT OYANT L FOUCHER F | 2014 | New Phytologist2014，202，1： | 1 |
| 20 | Genetic diversity among alfalfa (Medicago sativa ) cultivars coming from a breeding program, using SSR markers显示文摘 | Sandrine F Joelle R Pierre B | 2005 | Theoretical and Applied Genetics2005，111，： | 1 |
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