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| 1 | Hepatocellular carcinoma in cirrhosis: Incidence and risk factors显示文摘 | Giovanna Fattovich Tommaso Stroffolini Irene Zagni Francesco Donato | 2004 | Gastroenterology2004，，5： | 7 |
| 2 | Sustained virological response: A milestone in the treatment of chronic hepatitis C显示文摘AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples 'Federico Ⅱ'. At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33% survival rate in our cohort of patients after therapy for HCV infection. Finally, of the 27 patients who underwent a liver biopsy at the beginning of the study, a reduction in liver fibrosis was observed in 70.3% of the cases; only three cases registering values of liver stiffness indicative of significant fibrosis. CONCLUSION: Patients with CHC and SVR show an excellent prognosis with no risk of recurrence and a very low rate of mortality. Our data indicate that viruseradication following interferon treatment can last up to 20 years. | Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma Nicola Caporaso | 2013 | World Journal of Gastroenterology2013，19，18： | 4 |
| 3 | Hepatocellular carcinoma in cirrhosis: Incidence and risk factors显示文摘 | Giovanna Fattovich Tommaso Stroffolini Irene Zagni Francesco Donato | 2004 | Gastroenterology2004，，5： | 4 |
| 4 | Impact of comorbidities on the severity of chronic hepatitis B at presentation显示文摘AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B.METHODS:Out of 1366 hepatitis B surface antigen(HBsAg) positive subjects consecutively observed in 79 Italian hospitals,53(4.3%) showed as the only cofactor hepatitis D virus(HDV) infection [hepatitis B virus(HBV)/HDV group],130(9.5%) hepatitis C virus(HCV)(group HBV/HCV),6(0.4%) human immunodeficiencyvirus(HIV)(group HBV/HIV),138(10.2%) alcohol abuse(group HBV/alcohol);109(8.0%) subjects had at least two cofactors and 924 were in the cofactor-free(CF) group.RESULTS:Compared with patients in group CF those in group HBV/alcohol were older and more frequently had cirrhosis(P < 0.001),those in group HBV/HDV were younger(P < 0.001),more frequently resided in the south of the country and had cirrhosis(P <0.001),those in group HBV/HCV were older(P < 0.001) and more frequently had cirrhosis(P < 0.001).These cofactors were all independent predictors of liver cirrhosis in HBsAg positive patients.Multivariate analysis showed that an older age [odds ratio(OR) 1.06,95% CI:1.05-1.08],alcohol abuse with more than 8 drinks daily(OR 2.89,95% CI:1.81-4.62) and anti-HDV positivity(OR 3.48,95% CI:2.16-5.58) are all independently associated with liver cirrhosis.This association was found also for anti-HCV positivity in univariate analysis,but it was no longer associated(OR 1.23,95% CI:0.84-1.80) at multivariate analysis.CONCLUSION:Older age,HDV infection and alcohol abuse are the major determinants of severe liver disease in chronic HBV infection,while HCV replication plays a lesser role in the severity of hepatic damage. | Evangelista Sagnelli Tommaso Stroffolini Alfonso Mele Michele Imparato Caterina Sagnelli Nicola Coppola Piero Luigi Almasio | 2012 | World Journal of Gastroenterology2012，18，14： | 4 |
| 5 | Predicted Effects of Treatment for HCV Infection Vary Among European Countries显示文摘 | Sylvie Deuffic–Burban Pierre Deltenre Maria Buti Tommaso Stroffolini Julie Parkes Nikolai Mühlberger Uwe Siebert Christophe Moreno Angelos Hatzakis William Rosenberg Stefan Zeuzem Philippe Mathurin | 2012 | Gastroenterology2012，，4： | 2 |
| 6 | Hepatocellular carcinoma in cirrhosis:incidence and risk factors显示文摘 | Fattovich G Stroffolini T Zagni I | 2004 | Gastroenterology2004，127，： | 1 |
| 7 | On weakly A-harmonic tensors显示文摘 | STROFFOLINI B | 1995 | Studia Math1995，114，3： | 1 |
| 8 | Chron- ic hepatitis D: a vanishing disease? An Italian multicenter study 显示文摘 | GAETA GB STROFFOLINI T CHIARAMONTE M | 2000 | Hepatology2000，32，41： | 1 |
| 9 | Hepatitis delta in Europe; vanishing or refreshing? 显示文摘 | GAETA GB STROFFOLINI T SMEDILE A | 2007 | Hepatology2007，46，： | 1 |
| 10 | Hepatocellular carcinoma in cirrhosis and risk factors显示文摘 | Fattovich G Stroffolini T Zagni L | 2004 | G&stroenterology2004，127，51： | 1 |
| 11 | Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis显示文摘 | Chiaramonte M Stroffolini T Vian A | | 0，，： | 1 |
| 12 | Increasing hepatitis B vaccination coverage among healthcare workers in Italy 10 years apart显示文摘 | Stroffolini T Coppola R Carvelli C | 2008 | Dig Liver Dis2008，40，4： | 1 |
| 13 | On weakly A-harmonic tensors显示文摘 | Stroffolini B | 1995 | Studia Math1995，114，： | 1 |
| 14 | Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis显示文摘 | Chiaramonte M Stroffolini T Vian A | 1999 | Cancer1999，85，10： | 1 |
| 15 | Hepatocellular carcinoma in cirrhosis: Incidence and risk factors显示文摘 | Giovanna Fattovich Tommaso Stroffolini Irene Zagni Francesco Donato | 2004 | Gastroenterology2004，，5： | 1 |
| 16 | On weakly A -harmonic tensors显示文摘 | STROFFOLINI B | 1995 | Studia Math1995，114，3： | 1 |
| 17 | Hepatocellular carcinoma in cirrhosis= incidence and risk {actors 显示文摘 | Fattovich G Stroffolini T Zagnl I | 2004 | Gastroenterology2004，127，51： | 1 |
| 18 | Hepatoeellular carcinoma in cirrhosis: incidence and risk factors 显示文摘 | Fattovich G Stroffolini T Zagni I | 2004 | Gastroenterology2004，127，51： | 1 |
| 19 | AASLD Practice Guidline Chronic Hepatitis B and HBV infection in Italy显示文摘 | Stroffolini T Gaeta GB Mele A | 2007 | Hepatology2007，46，2： | 1 |
| 20 | Clearance of hepatitis B virus DNA and Pre-s surface antigens in patients with markers of acute viral replication显示文摘 | Delfini C Colloca S Stroffolini T | 1989 | J Med Virol1989，28，3： | 1 |
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