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| 1 | 胰腺实性-假乳头状肿瘤显示文摘 | Geers C Pierre M Jean-Francois G 刘飞飞(摘译) 张仁亚(摘译) | 2006 | 临床与实验病理学杂志2006，22，6： | 17 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis显示文摘Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application. | Chin-Ann J Ong Pierre Lao-Sirieix Rebecca C Fitzgerald | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 4 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 5 | Three decades of hepatitis B control with vaccination显示文摘Hepatitis B virus(HBV) continues to represent a major health problem and can lead to acute liver failure, acute hepatitis, chronic carriership, chronic hepatitis of HBV, liver cirrhosis, liver cancer, liver transplantation and death. There is a marked difference in the geographic distribution of carriers. More than 240 million people worldwide are chronic HBV carriers. Mother-to-child transmission remains the most important mechanism of infection in countries with a high prevalence of HBV. Percutaneous/parenteral transmission and unsafe sexual practices are important mode of spread transmission of HBV in other countries. Vaccination against HBV is the gold measure for primary prevention and control of the disease. Currently, 179 countries have added HBV vaccination to their routine vaccination programs with great results. Neonatal immunization with HBV vaccine has been one of the most highly effective measures in public health and the first anti-cancer program to be launched. In this paper we review the achievements for the last three decades. | Liliane C Meireles Rui Tato Marinho Pierre Van Damme | 2015 | World Journal of Hepatology2015，7，18： | 5 |
| 6 | 对比普通与灌注冷却射频消融电极在Ⅰ型心房扑动消融中的作用显示文摘目的对比普遍与灌注冷却射频消融电极在Ⅰ型心房扑动(CAFL)消融中的作用。方法60例CAFL患者随机分为两组:普通射频消融电极治疗组(CRF)和灌注冷却射频消融电极治疗组(IRF),分别比较两组取得下腔静脉与三尖瓣环峡部双向阻滞的手术时间、X线照射时间、射频消融放电次数及放电时间、并观察消融时电能、阻抗以及温度的改变。结果IRF组的手术时间、X线照射时间、射频消融时间均较CBF组短(P<0.01),放电次数也少(P<0.05),IRF组消融过程中阻抗变化小、电能稳定,温度差异不明显,而CRF组则相反,且有19例出现碳化现象,两组痛感差异无显著性,均无心包填塞、栓塞等并发症。结论灌注冷却射频消融电极在CAFL消融中优越于普通射频消融电极。 | 彭景添 Michel Haissaguerre Pierre Jais Dipen C shah Meleze Hocini | 2001 | 中国介入心脏病学杂志2001，9，1： | 3 |
| 7 | Aortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential Hypertension显示文摘 | Stéphane Laurent Sandrine Katsahian Céline Fassot Anne-Isabelle Tropeano Isabelle Gautier Brigitte Laloux Pierre Boutouyrie | 2003 | Stroke: Journal of the American Heart Association2003，，5： | 2 |
| 8 | Degradation Mechanisms of Vertical Cavity Surface Emitting Lasers, Quantum Electronics显示文摘 | Michael C Y Robert W H Pierre M P | 1996 | IEEE Journal1996，32，： | 2 |
| 9 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 10 | Rennet coagulation of skim milk and curd drainage: effect of pH, casein concentration, ionic strength and heat treatment 显示文摘 | Daviau C Famelart M H Pierre A | 2000 | Lait2000，80，4： | 1 |
| 11 | Atrial fibrillation associated minK 38G/S polymorphism modulates delayed rectifier current and membrane localization显示文摘 | Stephen Z Pierre C | 2005 | Cardiovasc Res2005，67，： | 1 |
| 12 | Nonlinear Normal modes, Invariance and modal dynamics approximations of nonlinear systems 显示文摘 | Nicolas B Pierre C Shaw S W | 1995 | Nonlinear Dynamics1995，8，： | 1 |
| 13 | Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp显示文摘 | Dubois J St- Pierre C | 2000 | J Antimicrob Chemother2000，45，1： | 1 |
| 14 | Complications of laparoscopy in gynecology显示文摘 | Chapron C Pierre F Querleu D | 2001 | Gynecol Obstet Fertil2001，29，9： | 1 |
| 15 | Free vibrations of beams with a single-edge crack显示文摘 | SHEN M PIERRE C | 1994 | J Sound Vib1994，170，： | 1 |
| 16 | Mode localization and eigenvalue loci veering phenomena in disordered structures显示文摘 | PIERRE C | 1988 | Journal of Sound and Vibration1988，126，3： | 1 |
| 17 | Arterial emboliz-ation for massive hematuria following transurethral prostatectomy显示文摘 | Michel F Dubruille T Jean- Pierre C | 2002 | J Urol2002，168，： | 1 |
| 18 | Mode Localization and Eigenvalue Loci Veering Phenomena in Disordered Structures显示文摘 | Pierre C | 1988 | Journal of Sound and Vibrarion1988，126，3： | 1 |
| 19 | Diffusionthrough CaSC>4 formed during the reaction of CaO withS02and 02显示文摘 | Hsia C? St Pierre GR Raghunathan K | 1993 | AIChE Journal1993，39，4： | 1 |
| 20 | Composition of reactive powder concretes显示文摘 | PIERRE R MARCEL C | 1995 | Cement and Concrete Research1995，25，7： | 1 |
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