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| 1 | Prognostic value of perioperative leukocyte count in resectable gastric cancer显示文摘AIM: To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer.METHODS: A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hematologic parameters and overall survival was assessed statistically, adjusted for known prognostic factors.RESULTS: The mean white blood cell count(WBC) significantly decreased after surgery, and 107/614(17.4%) patients developed p-leukopenia, which was defined as a preoperative WBC ≥ 4.0 × 109/L and postoperative WBC < 4.0 × 109/L, with an absolute decrease ≥ 0.5 × 109/L. The neutrophil count decreased significantly more than the lymphocyte count. P-leukopenia significantly correlated with poor tumor differentiation and preoperative WBC. A higher preoperative WBC and p-leukopenia were independent negative prognostic factors for survival [hazard ratio(HR) = 1.602, 95% confidence interval(CI): 1.185-2.165; P = 0.002, and HR = 1.478, 95%CI: 1.149-1.902; P = 0.002, respectively] after adjusting for histology, Borrmann type, p TNM stage, vascular or neural invasion, gastrectomy method, resection margins, chemotherapy regimens, and preoperative WBC count. The patients with both higher preoperative WBC and p- leukopenia had a worse prognosis compared to those with lower baseline WBC and no p-leukopenia(27.5 mo vs 57.3 mo, P < 0.001). CONCLUSION: Preoperative leukocytosis alone or in combination with postoperative leukopenia could be independent prognostic factors for survival in patients with resectable gastric cancer. | Xiao-Feng Chen Jing Qian Dong Pei Chen Zhou Oluf Dimitri R?e Fang Zhu Shao-Hua He Ying-Ying Qian Yue Zhou Jun Xu Jin Xu Xiao Li Guo-Qiang Ping Yi-Qian Liu Ping Wang Ren-Hua Guo Yong-Qian Shu | 2016 | World Journal of Gastroenterology2016，22，9： | 4 |
| 2 | Electrochemical probing into the active sites of graphitic-layer encapsulated iron oxygen reduction reaction electrocatalysts显示文摘The graphitic-layer encapsulated iron-containing nanoparticles(G@Fe) have been proposed as a potential type of active and stable non-precious metal electrocatalysts(NPMCs) for the oxygen reduction reaction(ORR). However, the contribution of the encapsulated components to the ORR activity is still unclear compared with the well-recognized surface coordinated FeN_x/C structure. Using the strong complexing effect of the iron component with anions, cyanide(CN^-) in alkaline and thiocyanate(SCN^-) in acidic media, the metal containing active sites are electrochemically probed. Three representative catalysts are chosen for a comparison including the as-prepared encapsulated G@Fe, commercial Fe/N/C catalyst with iron–nitrogen coordinated surface functionalities and molecular iron phthalocyanine(Fe Pc) containing well-defined structures and compositions. It was found that all samples showed significant shifts of half-wave potentials indicating that surface Fe coordinated sites in all cases. The G@Fe catalyst showed the weakest poisoning effect(the lowest shifts of half-wave potential) compared to the Fe/N/C and Fe Pc catalysts in both electrolytes. These results could be explained that the encapsulated iron components influence the FeN_x/C and/or N_xC surface functionality. | Lijie Zhong Jens Oluf Jensen Lars Nilausen Cleemann Chao Pan Qingfeng Li | 2018 | Science Bulletin2018，63，1： | 2 |
| 3 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 4 | Plant tissue culture. Biotechnology. Milestones显示文摘 | Oluf L. Gamborg | 2002 | In Vitro Cellular & Developmental Biology - Plant2002，，2： | 1 |
| 5 | Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study显示文摘 | Peter G?de Pernille Vedel Hans-Henrik Parving Oluf Pedersen | 1999 | The Lancet1999，，9153： | 1 |
| 6 | Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: Studies in 6018 whites显示文摘 | Dorit P. Jensen S?ren A. Urhammer Hans Eiberg Knut Borch-Johnsen Torben J?rgensen Torben Hansen Oluf Pedersen | 2006 | Molecular Genetics and Metabolism2006，，4： | 1 |
| 7 | Mutation analysis of the preproghrelin gene: No association with obesity and type 2 diabetes显示文摘 | Lesli H. Larsen Anette P. Gjesing Thorkild I.A. S?rensen Yasmin H. Hamid S?ren M. Echwald S?ren Toubro Eva Black Arne Astrup Torben Hansen Oluf Pedersen | 2005 | Clinical Biochemistry2005，，5： | 1 |
| 8 | Products formed during cobalt ce-menta- tion on zinc in zinc sulfate electrolytes显示文摘 | Oluf B Terje O | 2000 | Hydrometallur- gy2000，54，： | 1 |
| 9 | High temperature proton exchange membranes based on polybenzimidazoles for fuel cells显示文摘 | Qingfeng Li Jens Oluf Jensen Robert F. Savinell Niels J. Bjerrum | 2009 | Progress in Polymer Science2009，，5： | 1 |
| 10 | Genotype-by-nutrient interactions assessed in European obese women显示文摘 | Jose L. Santos Philippe Boutin Camilla Verdich Claus Holst Lesli H. Larsen Soren Toubro Christian Dina Wim H.M. Saris Ellen E. Blaak Johnatan Hoffstedt Moira A. Taylor Jan Polak Karine Clement Dominique Langin Arne Astrup Philippe Froguel Oluf Pedersen Th | 2006 | European Journal of Nutrition2006，，8： | 1 |
| 11 | MDM 2 is a useful prognostic biomarker for resectable gastric cancer显示文摘 | Yang Ye Xuan Li Jingjing Yang Shuhan Miao Shouyu Wang Yansu Chen Xiaowei Xia Xuming Wu Jianbing Zhang Yan Zhou Song He Yongfei Tan Fulin Qiang Gang Li Oluf Dimitri R?e Jianwei Zhou | 2013 | Cancer Sci2013，，5： | 1 |
| 12 | Fertilizers, agronomy and N2O显示文摘 | Oluf Chr. B?ckman Hans-Werner Olfs | 1998 | Nutrient Cycling in Agroecosystems (-)1998，，2： | 1 |
| 13 | The effects of amino acids and ammonium on the growth of plant cells in suspension culture显示文摘 | Oluf L G | 1970 | Plant Physiol1970，45，4： | 1 |
| 14 | High temperature proton exchange membranes based on polybenzimidazoles for fuel cells显示文摘 | Qingfeng Li Jens Oluf Jensen Robert F. Savinell Niels J. Bjerrum | 2009 | Progress in Polymer Science2009，，5： | 1 |
| 15 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
| 16 | 新整合式NFC卷标/传感器组件——低成本、低功率射频技术如何发展出新的应用显示文摘全球约有3.66亿糖尿病患,这当中有许多糖尿病患者必须以刺破皮肤引流血液的方式定期自我检测血糖值,而且最让他们反感的就是必须定期重复这项检测。 | Oluf Alminde | 2014 | 中国集成电路2014，23，10： | 0 |
| 17 | Proton Exchange Membranes for Fuel Cells Challenges and Recent Developments显示文摘 | Jens Oluf Jensen Pernille P. Noyé Niels J. Bjerrum | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
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