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| 1 | Facile design of Au@Pt core-shell nanostructures: Formation of Pt submonolayers with tunable coverage and their applications in electrocatalysis显示文摘 | Fulin Zheng Wing-Tak Wong Ka-Fu Yung | 2014 | Nano Research2014，7，3： | 17 |
| 2 | Recent progress and application on seismic isolation energy dissipation and control for structures in China显示文摘China is a country where 100% of the territory is located in a seismic zone. Most of the strong earthquakes are over prediction. Most fatalities are caused by structural collapse. Earthquakes not only cause severe damage to structures, but can also damage non-structural elements on and inside of facilities. This can halt city life, and disrupt hospitals, airports, bridges, power plants, and other infrastructure. Designers need to use new techniques to protect structures and facilities inside. Isolation, energy dissipation and, control systems are more and more widely used in recent years in China. Currently, there are nearly 6,500 structures with isolation and about 3,000 structures with passive energy dissipation or hybrid control in China. The mitigation techniques are applied to structures like residential buildings, large or complex structures, bridges, underwater tunnels, historical or cultural relic sites, and industrial facilities, and are used for retrofitting of existed structures. This paper introduces design rules and some new and innovative devices for seismic isolation, energy dissipation and hybrid control for civil and industrial structures. This paper also discusses the development trends for seismic resistance, seismic isolation, passive and active control techniques for the future in China and in the world. | Zhou Fulin Tan Ping | 2018 | Earthquake Engineering and Engineering Vibration2018，17，1： | 15 |
| 3 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 4 | High-security-level multi-dimensional optical storage medium:nanostructured glass embedded with LiGa_(5)O_(8):Mn^(2+) with photostimulated luminescence显示文摘The launch of the big data era puts forward challenges for information preservation technology,both in storage capacity and security.Herein,a brand new optical storage medium,transparent glass ceramic(TGC)embedded with photostimulated LiGa5O8:Mn2+nanocrystals,capable of achieving bit-by-bit optical data write-in and read-out in a photon trapping/detrapping mode,is developed.The highly ordered nanostructure enables light–matter interaction with high encoding/decoding resolution and low bit error rate.Importantly,going beyond traditional 2D optical storage,the high transparency of the studied bulk medium makes 3D volumetric optical data storage(ODS)possible,which brings about the merits of expanded storage capacity and improved information security.Demonstration application confirmed the erasable-rewritable 3D storage of binary data and display items in TGC with intensity/wavelength multiplexing.The present work highlights a great leap in photostimulated material for ODS application and hopefully stimulates the development of new multi-dimensional ODS media. | Shisheng Lin Hang Lin Chonggeng Ma Yao Cheng Sizhe Ye Fulin Lin Renfu Li Ju Xu Yuansheng Wang | 2020 | Light(Science & Applications)2020，9，1： | 12 |
| 5 | Dynamic characteristics of a novel damped outrigger system显示文摘This paper presents exact analytical solutions for a novel damped outrigger system, in which viscous dampers are vertically installed between perimeter columns and the core of a high-rise building. An improved analytical model is developed by modeling the effect of the damped outrigger as a general rotational spring acting on a Bernoulli-Euler beam. The equivalent rotational spring stiffness incorporating the combined effects of dampers and axial stiffness of perimeter columns is derived. The dynamic stiffness method(DSM) is applied to formulate the governing equation of the damped outrigger system. The accuracy and effi ciency are verifi ed in comparison with those obtained from compatibility equations and boundary equations. Parametric analysis of three non-dimensional factors is conducted to evaluate the infl uences of various factors, such as the stiffness ratio of the core to the beam, position of the damped outrigger, and the installed damping coeffi cient. Results show that the modal damping ratio is signifi cantly infl uenced by the stiffness ratio of the core to the column, and is more sensitive to damping than the position of the damped outrigger. The proposed analytical model in combination with DSM can be extended to the study of structures with more outriggers. | Tan Ping Fang Chuangjie Zhou Fulin | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 11 |
| 6 | A comparative study on source apportionment of polycyclic aromatic hydrocarbons in sediments of the Daliao River,China:Positive matrix factorization and factor analysis with non-negative constraints显示文摘Two receptor models,positive matrix factorization (PMF) and factor analysis with non-negative constraints (FA-NNC),were applied for source apportionment of polycyclic aromatic hydrocarbons (PAHs) in sediments of the Daliao River,China.The source profiles and source contributions derived from the two receptor models were comparable.For PMF,PAHs mainly came from coal combustion (43.3%),followed by biomass burning (24.3%),traffic emissions (16.7%) and coke oven (15.7%).As for FA-NNC,coal combustion (50.4%) was dominant,followed by biomass burning (21.9%),traffic emission (15.7%) and coke oven (12.0%).The source apportionment results are consistent with the results from the specific PAH diagnostic ratios and emission inventory analysis.In addition,the source apportionment results are consistent with the structure of energy material usage in Liaoning Province of China. | LIU ChunHui TIAN FuLin CHEN JingWen LI XueHua QIAO XianLiang | 2010 | Chinese Science Bulletin2010，55，10： | 10 |
| 7 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 8 | Evaluation of the Effectiveness of Financial Support to Agriculture Based on the DEA Method显示文摘Financial support to agriculture is the main driving force to increase farmers' income. This paper applied the evaluation DEA(Data-embrasing Analysis) method to evaluate the effectiveness of f inancial support to agriculture from 1990 to 2005. It is found that the trend of the fi nancial support to agricultural effectiveness in China presented a downward trend in recent years. The results showed that the overall trend of the fi nancial support to agriculture in China wasn't high,and some corresponding proposals were put forward to optimized. | SUO Ruixia WANG Fulin | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，3： | 8 |
| 9 | Accelerated flow softening and dynamic transformation of Ti-6Al-4V alloy in two-phase region during hot deformation via coarsening αgrain显示文摘The flow softening is an important phenomenon during hot deformation of metallic materials.In the present work,a more evident flow softening of Ti-6 Al-4 V alloy when deformed in two-phase region was observed in coarser a grain sample,which was attributed to an accelerated dynamic transformation from harder α phase into β phases.Notably,full β microstructure was observed in coarse grain samples at strain of 1.2,while retained a phase was observed in fine a grain specimens.In the views of thermodynamics and crystallographic analysis,the in-depth mechanisms of dynamic transformation were further investigated. | Xiankun Ji Baoqi Guo Fulin Jiang Hong Yu Dingfa Fu Jie Teng Hui Zhang John J.Jonas | 2020 | Journal of Materials Science & Technology2020，36，1： | 5 |
| 10 | Development and performance evaluation of an innovative low-cost seismic isolator显示文摘This paper proposes an innovative low-cost isolator with lightweight and cost-effective features for use in low-rise residential buildings.The low-cost laminated isolator is formed by plastic shims with unsaturated polyester fiber reinforcement between rubber layers.Performance tests are systematically carried out to characterize the isolator in terms of mechanic behavior(e.g.,compression,shear,and their relationship),dynamic properties(e.g.,damping),and ultimate states.A design guideline and associated criteria of the low-cost isolator are also provided and discussed in this study.To investigate more detailed behavior,a finite element model of the isolator is developed in ABAQUS and calibrated by the experimental data.The research presented in this paper makes significant contributions to the evaluation of the peak stress and strain demands on isolator’s components and provides technical support for the design and manufacturing of this new type of isolator. | TAN Ping XU Kai WANG Bin CHANG ChiaMing LIU Han ZHOU FuLin | 2014 | Science China(Technological Sciences)2014，57，10： | 5 |
| 11 | Flexible high energy density zinc-ion batteries enabled by binder-free MnO_(2)/reduced graphene oxide electrode显示文摘We demonstrate a rechargeable zinc-ion battery with high energy density and cyclability using MnO_(2)and reduced graphene oxide(MnO_(2)/rGO)electrode.The flexible and binder free electrode,with high MnO_(2)mass ratio(80 wt%of MnO_(2)),is fabricated using vacuum filtration without any additional additives other than rGO.Compared to batteries with conventional MnO_(2)electrodes,the Zn-MnO_(2)/rGO battery shows a significant enhanced capacity(332.2 mAh g^(-1)at 0.3 A g^(-1)),improved rate capability(172.3 mAh g^(-1)at 6 A g^(-1))and cyclability.The capacity retention remains 96%after 500 charge/discharge cycles at 6 A g^(-1).The high MnO_(2)mass ratio makes MnO_(2)/rGO electrode advantageous when the capacity is normalized to the whole electrode,particularly at high rates.The calculated gravimetric energy density of Zn-MnO_(2)/rGO battery is 33.17Wh kg^(-1),which is comparable to the existing commercial lead-acid batteries(30-40Wh kg^(-1)).Furthermore,the discharge profile and capacity of our Zn-MnO_(2)/rGO battery shows no deterioration during bending test,indicating good flexibility.As a result,zinc-ion battery is believed to be a promising technology for powering next generation flexible electronics. | Yuan Huang Jiuwei Liu Qiyao Huang Zijian Zheng Pritesh Hiralal Fulin Zheng Dilek Ozgit Sikai Su Shuming Chen Ping-Heng Tan Shengdong Zhang Hang Zhou | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 12 | Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells. | Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen | 2013 | Neural Regeneration Research2013，8，4： | 4 |
| 13 | Earthquake Response and Isolation Layer Parameter Effect of Seismic Isolation Systems of Transformers With Bushings显示文摘国内外震害表明,变压器在地震中的破坏型式多样,易损性极高。隔震技术是一项能够有效降低地震反应的新型抗震技术,而变压器及套管隔震层的设计和参数选择与普通结构有较大的差异。首先,建立了大型电力变压器及套管隔震体系的多质点分析模型,采用Matlab软件编写计算程序,分别输入人工地震波和Taft地震波,对变压器及套管隔震体系的地震响应进行分析;最后,开展了隔震层等效水平网0度、等效阻尼比、双线性恢复力模型的屈服剪力系数及屈服后刚度等参数的地震响应影响分析。分析结果表明:合理设计变压器及套管隔震体系的隔震层参数,可有效降低变压器及套管的地震响应;另外,通过隔震层的参数分析,得到了相关参数的合理取值范围。该研究对今后变压器及套管隔震体系的设计具有参考与指导作用。 | CAO Meigen ZHOU Fulin TAN Ping ZHANG Guangping GAO Zhengguo | 2012 | 中国电机工程学报2012，32，13： | 4 |
| 14 | Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair显示文摘Silk fibroin(SF)is considered biocompatible and biodegradable for osteochondral repair.However,it lacks a bioactive domain for cell adhesion,proliferation and differentiation,limiting its therapeutic efficacy.To revamp SF as a biomimicking and bioactive microenvironment to regulate cell behaviours,we engineered an elastin-like polypeptide(ELP,Val-Pro-Gly-Xaa-Gly)to modify SF fibers via simple and green dehydrothermal(DHT)treatment.Our results demonstrated that the ELP successfully bound to SF,and the scaffold was reinforced by the fusion of the silk fiber intersections with ELP(S-ELP-DHT)via the DHT treatment.Both bone mesenchymal stem cells(BMSCs)and chondrocytes exhibited improved spreading and proliferation on the S-ELP-DHT scaffolds.The ex vivo and in vivo experiments further demonstrated enhanced mature bone and cartilage tissue formation using the S-ELP-DHT scaffolds compared to the naked SF scaffolds.These results indicated that a recombinant ELPmodified silk scaffold can mimic three-dimensional(3D)cell microenvironment,and improve bone and cartilage regeneration.We envision that our scaffolds have huge clinical potential for osteochondral repair. | Zhuoyue Chen Qiang Zhang Hongmin Li Qi Wei Xin Zhao Fulin Chen | 2021 | Bioactive Materials2021，6，3： | 4 |
| 15 | Performance improvement of optimization solutions by POD-based data mining显示文摘The performance of an optimized aerodynamic shape is further improved by a second-step optimization using the design knowledge discovered by a data mining technique based on Proper Orthogonal Decomposition(POD) in the present study. Data generated in the first-step optimization by using evolution algorithms is saved as the source data, among which the superior data with improved objectives and maintained constraints is chosen. Only the geometry components of the superior data are picked out and used for constructing the snapshots of POD. Geometry characteristics of the superior data illustrated by POD bases are the design knowledge, by which the second-step optimization can be rapidly achieved. The optimization methods are demonstrated by redesigning a transonic compressor rotor blade, NASA Rotor 37, in the study to maximize the peak adiabatic efficiency, while maintaining the total pressure ratio and mass flow rate.Firstly, the blade is redesigned by using a particle swarm optimization method, and the adiabatic efficiency is increased by 1.29%. Then, the second-step optimization is performed by using the design knowledge, and a 0.25% gain on the adiabatic efficiency is obtained. The results are presented and addressed in detail, demonstrating that geometry variations significantly change the pattern and strength of the shock wave in the blade passage. The former reduces the separation loss,while the latter reduces the shock loss, and both favor an increase of the adiabatic efficiency. | Yanhui DUAN Wenhua WU Peihong ZHANG Fulin TONG Zhaolin FAN Guiyu ZHOU Jiaqi LUO | 2019 | Chinese Journal of Aeronautics2019，32，4： | 3 |
| 16 | Scheduling Framework Using Dynamic Optimal Power Flow for Battery Energy Storage Systems显示文摘Battery energy storage systems(BESS)are instrumental in the transition to a low carbon electrical network with enhanced flexibility,however,the set objective can be accomplished only through suitable scheduling of their operation.This paper develops a dynamic optimal power flow(DOPF)-based scheduling framework to optimize the day(s)-ahead operation of a grid-scale BESS aiming to mitigate the predicted limits on the renewable energy generation as well as smooth out the network demand to be supplied by conventional generators.In DOPF,all the generating units,including the ones that model the exports and imports of the BESS,across the entire network and the complete time horizon are integrated on to a single network.Subsequently,an AC-OPF is applied to dispatch their power outputs to minimize the total generation cost,while satisfying the power balance equations,and handling the unit and network constraints at each time step coupled with intertemporal constraints associated with the state of charge(SOC).Furthermore,the DOPF developed here entails the frequently applied constant current-constant voltage charging profile,which is represented in the SOC domain.Considering the practical application of a 1 MW BESS on a particular 33 kV network,the scheduling framework is designed to meet the pragmatic requirements of the optimum utilization of the available energy capacity of BESS in each cycle,while completing up to one cycle per day. | Fulin Fan Ivana Kockar Han Xu Jingsi Li | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 3 |
| 17 | Influence of Ni interlayer on interfacial microstructure and mechanical properties of Ti-6Al-4V/AZ91D bimetals fabricated by a solid–liquid compound casting process显示文摘The solid–liquid compound casting of Mg-AZ91D and Ti-TC4 alloys was developed by using pure Ni electro-deposited coating.The pouring temperatures of 660℃,690℃,720℃and 750℃were chosen to investigated the effects of casting temperatures on microstructural evolution,properties,and fracture behaviors of Ni-coated TC4/AZ91D bimetals by the solid–liquid compound casting(SLCC).The scanning electron microscopy(SEM)and the energy dispersive spectroscopy(EDS)results showed that the interfacial zone mainly composed of nickel,Mg_(2)Ni and Mg-Al-Ni in the bimetals cast at 660℃.As the pouring temperature was increased to 750℃,the width of the interface zone,which mainly composed ofδ(Mg),Mg_(2)Ni,Mg-Al-Ni,Mg_(3)TiNi_(2) and Al_(3)Ni,gradually increased.The microhardness tests showed that the micro-hardness of the interface zone was smaller than that of TC4 substrate but larger than that of the cast AZ91D matrix.At the pouring temperature of 720℃,the Ni-coated TC4/AZ91D bimetals had the most typical homogeneous interface,which had granular Mg-Al-Ni ternary phase but no ribbon-like Al3Ni binary phase,and achieved the highest shear strength of 97.35MPa.Meanwhile,further fracture behavior analysis showed that most fracture failure of Ni-coated TC4/AZ91D bimetals occurred at the Mg_(2)Ni+δ(Mg)eutectic structure and Al_(3)Ni hard intermetallic. | Fulin Wen Jianhua Zhao Miaowang Yuan Jingfeng Wang Dengzhi Zheng Jinyong Zhang Ke He Jingjing Shangguan Yu Guo | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 18 | Review on graph learning for dimensionality reduction of hyperspectral image显示文摘Graph learning is an effective manner to analyze the intrinsic properties of data.It has been widely used in the fields of dimensionality reduction and classification for data.In this paper,we focus on the graph learning-based dimensionality reduction for a hyperspectral image.Firstly,we review the development of graph learning and its application in a hyperspectral image.Then,we mainly discuss several representative graph methods including two manifold learning methods,two sparse graph learning methods,and two hypergraph learning methods.For manifold learning,we analyze neighborhood preserving embedding and locality preserving projections which are two classic manifold learning methods and can be transformed into the form of a graph.For sparse graph,we introduce sparsity preserving graph embedding and sparse graph-based discriminant analysis which can adaptively reveal data structure to construct a graph.For hypergraph learning,we review binary hypergraph and discriminant hyper-Laplacian projection which can represent the high-order relationship of data. | Liangpei Zhang Fulin Luo | 2020 | Geo-Spatial Information Science2020，23，1： | 3 |
| 19 | Direct numerical simulation of impinging shock wave and turbulent boundary layer interaction over a wavy-wall显示文摘The interaction of an impinging oblique shock wave with an angle of 30°and a supersonic turbulent boundary layer at Ma_(∞)=2.9 and Re_(θ)=2400 over a wavy-wall is investigated through direct numerical simulation and compared with the interaction on a flat-plate under the same flow conditions.A sinusoidal wave with amplitude to wavelength ratio of 0.26 moves in the streamwise direction and is uniformly distributed across the spanwise direction.The influences of the wavy-wall on the interaction,including the characterization of the flow field,the skin-friction,pressure and the budget of turbulence kinetic energy,are systematically studied.The region of separation grows slightly and decomposes into four bubbles.Local peaks of skin-friction are observed at the rear part of the interaction region.The low-frequency shock motion can be seen in the wall pressure spectra.Analyses of the turbulence kinetic energy budget indicate that both diffusion and transport significantly increase near the crests,balanced by an amplified dissipation in the near-wall region.Proper orthogonal decomposition analyses show that the most energetic structures are associated with the separated shock and the shear layer over the bubbles.Only the bubbles in the first two troughs are dominated by a low-frequency enlargement or shrinkage. | Fulin TONG Dong SUN Xinliang LI | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 20 | HER2 gene status and the relationship with p21 protein expression in gastric cancer显示文摘我们瞄准了到分析的目的有在胃的癌的 p21 蛋白质表示的 HER2 基因地位和它的关系。在 situ 杂交(鱼) 和 immunohistochemistry (IHC ) 的方法荧光技术被用来在胃的癌症的 59 种情况中检测 HER2 基因地位和 p53 蛋白质。HER2 基因扩大率的结果鱼察觉是 16.9%(10/59 ) ,在没有拷贝数字获得的 49 种情况中的 HER2 基因扩大和基因扩大是 49.2% 的一个总数(29/59 ) 。HER2 蛋白质表示是 42.4%(25/59 ) ,在有 +++ 的病人的 HER2 基因扩大率,, ++ HER2 蛋白质表示在有 + HER2 蛋白质表示的病人是 3/3 和 5/8,它是 2/14,有重要差别(P < 0.05 ) 。p21 蛋白质表示率是 49.2%(29/59 ) , HER2 基因扩大率和 p21 蛋白质表示在肿瘤侵略深度有重要差别,淋巴节点转移(P < 0.05 ) ;在组织学的类型的有的不统计的意义,变老,性差别(P > 0.05 ) 。结论 HER2 基因扩大率和基因拷贝数字断然与 p21 蛋白质表示, HER2 基因地位和联合察觉能提供的 p21 蛋白质的表示有关联在胃的癌症转移,病人条件开发和预后的引用值,它能也指导单个治疗的临床的开发。 | Yongjie Li Yangkun Wang Xianwei Zhang Fulin Li Nianlong Meng Xutao Yuan Jinsheng Song | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
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