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| 1 | Climate Change, Risk and Grain Yields in China显示文摘Adopting Just and Pope (1978, 1979) style yield functions, this paper proposes a method to analyze the impacts of regional climate change on grain production in China. We find that changes in climate will affect grain production in North and South China differently. Specifically, it emerges that a 1℃ increase in annual average temperature could reduce national grain output by 1.45% (1.74% reduction in North China and 1.19% reduction in South China), while an increase in total annual precipitation of around 100 mm could increase national grain output by 1.31% (3.0% increase in North China and 0.59% reduction in South China). | Rainer Holst Xiaohua Yu Carola Grün | 2013 | Journal of Integrative Agriculture2013，12，7： | 14 |
| 2 | Effects of Irrigation on Nitrous Oxide,Methane and Carbon Dioxide Fluxes in an Inner Mongolian Steppe显示文摘Increased precipitation during the vegetation periods was observed in and further predicted for Inner Mongolia. The changes in the associated soil moisture may affect the biosphere-atmosphere exchange of greenhouse gases. Therefore, we set up an irrigation experiment with one watered (W) and one unwatered plot (UW) at a winter-grazed Leymus chinensis-steppe site in the Xilin River catchment, Inner Mongolia. UW only received the natural precipitation of 2005 (129 mm), whereas W was additionally watered after the precipitation data of 1998 (in total 427 mm). In the 3-hour resolution, we determined nitrous oxide (N2O), methane (CH4) and carbon dioxide (CO2) fluxes at both plots between May and September 2005, using a fully automated, chamber-based measuring system. N2O fluxes in the steppe were very low, with mean emissions (±s.e.) of 0.9±0.5 and 0.7±0.5 μg N m-2 h-1 at W and UW, respectively. The steppe soil always served as a CH4 sink, with mean fluxes of -24.1±3.9 and -31.1 ± 5.3 μg C m-2 h-1 at W and UW. Nighttime mean CO2 emissions were 82.6±8.7 and 26.3±1.7 mg C m-2 h-1 at W and UW, respectively, coinciding with an almost doubled aboveground plant biomass at W. Our results indicate that the ecosystem CO2 respiration responded sensitively to increased water input during the vegetation period, whereas the effects on CH4 and N2O fluxes were weak, most likely due to the high evapotranspiration and the lack of substrate for N2O producing processes. Based on our results, we hypothesize that with the gradual increase of summertime precipitation in Inner Mongolia, ecosystem CO2 respiration will be enhanced and CH4 uptake by the steppe soils will be lightly inhibited. | 刘春岩 Jirko HOLST Nicolas BRGGEMANN Klaus BUTTERBACH-BAHL 姚志生 韩圣慧 韩兴国 郑循华 | 2008 | Advances in Atmospheric Sciences2008，25，5： | 7 |
| 3 | Nutrition in chronic pancreatitis显示文摘The pancreas is a major player in nutrient digestion.In chronic pancreatitis both exocrine and endocrine insufficiency may develop leading to malnutrition over time.Maldigestion is often a late complication of chronic pancreatic and depends on the severity of the underlying disease.The severity of malnutrition is correlated with two major factors:(1)malabsorption and depletion of nutrients(e.g.,alcoholism and pain)causes impaired nutritional status;and(2)increased metabolic activity due to the severity of the disease.Nutritional deficiencies negatively affect outcome if they are not treated.Nutritional assessment and the clinical severity of the disease are important for planning any nutritional intervention.Good nutritional practice includes screening to identify patients at risk,followed by a thoroughly nutritional assessment and nutrition plan for risk patients.Treatment should be multidisciplinary and the mainstay of treatment is abstinence from alcohol,pain treatment,dietary modifications and pancreatic enzyme supplementation.To achieve energy-end protein requirements,oral supplementation might be beneficial.Enteral nutrition may be used when patients do not have sufficient calorie intake as in pylero-duodenalstenosis,inflammation or prior to surgery and can be necessary if weight loss continues.Parenteral nutrition is very seldom used in patients with chronic pancreatitis and should only be used in case of GI-tract obstruction or as a supplement to enteral nutrition. | Henrik Hφjgaard Rasmussen φivind Irtun Sφren Schou Olesen Asbjφrn Mohr Drewes Mette Holst | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 4 | Antimicrobial Profile of Lactic Acid Bacteria Isolated from Vegetables and Indigenous Fermented Foods of India against Clinical Pathogens Using Microdilution Method显示文摘In dairy and food industries lactic acid bacteria(LAB)have been used in form of starter culture that plays vital role in fermentation;as flavouring and texturizing or as preservative agents.There is increasing evidence that lactobacilli which inhabit the gastrointestinal tract develop antimicrobial activities and participatein the host’s defence system[1].During fermentation,most of the LAB produces a number of different compounds like organic acids,hydrogen peroxide,diacetyl,acetaldehyde,carbon dioxide,polysaccharides,and proteinaceous compounds called bacteriocins or bacteriocinogenic peptides[2-3].Such metabolites exert antimicrobial activity and | Ami PATEL Nihir SHAH Padma AMBALAM J. B. PRAJAPATI Olle HOLST Asa LJUNGH | 2013 | Biomedical and Environmental Sciences2013，26，9： | 4 |
| 5 | Sensitivity of precipitation statistics to urban growth in a subtropical coastal megacity cluster显示文摘This short paper presents an investigation on how human activities may or may not affect precipitation based on numerical simulations of precipitation in a benchmark case with modified lower boundary conditions, representing different stages of urban development in the model. The results indicate that certain degrees of urbanization affect the likelihood of heavy precipitation significantly, while less urbanized or smaller cities are much less prone to these effects. Such a result can be explained based on our previous work where the sensitivity of precipitation statistics to surface anthropogenic heat sources lies in the generation of buoyancy and turbulence in the planetary boundary layer and dissipation through triggering of convection. Thus only mega cities of sufficient size, and hence human-activity-related anthropogenic heat emission, can expect to experience such effects. In other words, as cities grow, their effects upon precipitation appear to grow as well. | Christopher Claus Holst Johnny C.L.Chan Chi-Yung Tam | 2017 | Journal of Environmental Sciences2017，29，9： | 3 |
| 6 | Trust and tacit knowledge sharing and use显示文摘 | J. Scott Holste Dail Fields | 2010 | Journal of Knowledge Management2010，，1： | 3 |
| 7 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 8 | Estrogen receptor alpha gene amplification in breast cancer:25 years of debate显示文摘Twenty-five years ago,Nembrot and colleagues reported amplification of the estrogen receptor alpha gene(ESR1) in breast cancer,initiating a broad and still ongoing scientific debate on the prevalence and clinical significance of this genetic aberration,which affects one of the most important genes in breast cancer.Since then,a multitude of studies on this topic has been published,covering a wide range of divergent results and arguments.The reported prevalence of this alteration in breast cancer ranges from 0% to 75%,suggesting that ESR1 copy number analysis is hampered by technical and interpreter issues.To date,two major issues related to ESR1 amplification remain to be conclusively addressed:(1) The extent to which abundant amounts of messenger RNA can mimic amplification in standard fluorescence in situ hybridization assays in the analysis of strongly expressed genes like ESR1,and(2) the clinical relevance of ESR1 amplification:Such relevance is strongly disputed,with data showing predictive value for response as well as for resistance of the cancer to anti-estrogen therapies,or for subsequent development of cancers in the case of precursor lesions that display amplification of ESR1.This review provides a comprehensive summary of the various views on ESR1 amplification,and highlights explanations for the contradictions and conflicting data that could inform future ESR1 research. | Frederik Holst | 2016 | World Journal of Clinical Oncology2016，7，2： | 2 |
| 9 | 大鼠胚胎视网膜前体细胞的分离、体外培养及鉴定显示文摘目的探讨流式细胞分析技术、免疫荧光及3HThymidine分析对大鼠胚胎视网膜前体细胞性质及其体外增殖进行鉴定的可行性。方法来源于19d胚胎大鼠视网膜的视网膜前体细胞,使用流式细胞分析及免疫荧光技术从数量及形态上对细胞性质进行鉴定。采用无血清培养基体外培养,通过3HThymidine分析、形态学观察及统计学分析,研究细胞增殖情况。结果从胚胎大鼠全层视网膜分离出的原代视网膜前体细胞,流式细胞分析结果显示:培养0d时,22.23%的细胞神经上皮干细胞蛋白(Nestin)呈阳性表达,16.04%的细胞Sox2呈阳性表达,19.66%的细胞钙结合蛋白呈阳性表达,其余终末视网膜细胞标记物(胶质纤维酸性蛋白、CD90、视紫红质、C反应蛋白、突触前膜列阵蛋白)均呈极微量阳性或阴性。免疫荧光结果显示大部分细胞及细胞球(>90%)Nestin呈阳性表达。培养6d后,流式细胞分析显示43.36%的细胞Nestin阳性,免疫荧光显示Nestin及胶质纤维酸性蛋白呈阳性。连续4d3HThymidine分析及形态学观察、统计学分析原代视网膜前体细胞初期增殖良好。结论流式细胞分析、免疫荧光及3HThymidine等免疫学技术可很好的对视网膜前体细胞性质及其增殖情况进行鉴定。大鼠胚胎原代视网膜前体细胞表现出神经干细胞的特性,根据检测手段不同,阳性结果不同,其原代视网膜前体细胞体外培养初期增殖良好。 | 杨静 Mogens Holst Nissen 王薇 | 2006 | 中华眼科杂志2006，42，2： | 2 |
| 10 | 环甲膜切开术后的环甲肌和环甲膜的愈合显示文摘本文综合节译同一作者两篇关于环甲膜切开术后环甲肌功能、组织学以及愈合过程的动物实验研究,指出手术不影响环甲肌,也不形成喉狭窄。 | Holst M 李源 | 1990 | 国外医学(耳鼻咽喉科学分册)1990，14，5： | 2 |
| 11 | 一把椅子抵住这时间的洪流显示文摘关于人与物是如何互相影响的,我想一把汉斯·瓦格纳(HANS J.WEGNER)的椅子便能说明这两者间全部的关系。 | msright PP M?bler Mikkel Adsb?l Jens Mourits S?rensen Erik Brahl Rasmus Koch Studio Katja Kejser Kasper Holst Pedersen | 2015 | 设计2015，28，22： | 2 |
| 12 | Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum显示文摘 | Jrgensen M M Jensen O N Holst H U | 2000 | J Biol Chem2000，275，33： | 1 |
| 13 | Field weed population dynamics:a review of model approaches and applications显示文摘 | Holst N Rasmussen I A Bastiaans L | 2007 | Weed Research2007，47，： | 1 |
| 14 | On Target Maneuvers in Bearings only Tracking显示文摘 | A Holtsberg | 1991 | IEEE AES1991，，： | 1 |
| 15 | Temporal and spatial dynamics of planktonic rotifers in the Elbe Estuary during spring显示文摘 | Holst H Zimmermann H Kausch H | 1998 | Estuarine Coastal and Shelf Science1998，47，3： | 1 |
| 16 | Degradation of microcystin in sediments at oxic and anoxic denitrifying conditions 显示文摘 | Holst T Jorgensen N O G Jorgensen C | 2003 | Water Res2003，37，19： | 1 |
| 17 | The physiology of glucagon-like peptide 1显示文摘 | Holst JJ | 2007 | Physiol Rev2007，87，4： | 1 |
| 18 | Reduced accumulation of specific microRNAs in colorectal neo?plasia显示文摘 | MICHAEL MZ SM OC VAN HOLST PELLEKAAN NG | 2003 | Mol Cancer Res2003，1，： | 1 |
| 19 | Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes:comparison,efficacy and safety 显示文摘 | Deacon CF Holst J1 | 2013 | Exp OpinPharm2013，14，15： | 1 |
| 20 | Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus显示文摘 | Gutniak M Orskov C Holst JJ | 1992 | N Engl J Med1992，326，20： | 1 |
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