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| 1 | Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer显示文摘AIM: To evaluate the role of positron emission tomo-graphy using 18F-fluorodeoxyglucose (FDG-PET) in the surgical management of patients with pancreatic cancer, including the diagnosis, staging, and selection of patients for the subsequent surgical treatment.METHODS: This study involved 53 patients with proven primary pancreatic cancer. The sensitivity of diagnosing the primary cancer was examined for FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of carcinoembrionic antigens (CEA) and carbohydrate antigen 19-9 (CA19-9). Next, the accuracy of staging was compared between FDG-PET and CT. Finally, FDG-PET was analyzed semiquantitatively using the standard uptake value (SUV). The impact of the SUV on patient management was evaluated by examining the correlations between the SUV and the histological findings of cancer.RESULTS: The sensitivity of FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of CEA and CA19-9 were 92.5%, 88.7%, 46.4%, 37.7% and 69.8%, respectively. In staging, FDG-PET was superior to CT only in diagnosing distant disease (bone metastasis). For local staging, the sensitivity of CT was better than that of FDG-PET. The SUV did not correlate with the pTNM stage, grades, invasions to the vessels and nerve, or with the size of the tumor. However, there was a statistically significant difference (4.6 ± 2.9 vs 7.8 ± 4.5, P = 0.024) in the SUV between patients with respectable and unresectable disease.CONCLUSION: FDG-PET is thus considered to be useful in the diagnosis of pancreatic cancer. However, regarding the staging of the disease, FDG-PET is not considered to be a sufficiently accurate diagnostic modality. Although the SUV does not correlate with the patho-histological prognostic factors, it may be useful in selecting patients who should undergo subsequent surgical treatment. | Hisao Wakabayashi Yoshihiro Nishiyama Tsuyoshi Otani Takanori Sano Shinichi Yachida Keiichi Okano Kunihiko Izuishi Yasuyuki Suzuki | 2008 | World Journal of Gastroenterology2008，14，1： | 16 |
| 2 | Inflammation-based factors and prognosis in patients with colorectal cancer显示文摘Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival. | Kiyoshi Maeda Masatusne Shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 12 |
| 3 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 6 |
| 4 | 肝细胞癌、肝内胆管细胞癌与肝样癌的鉴别中BSEP和MDR3是一种非常有用的免疫组化标志物显示文摘作者分析两种肝细胞特异性转运蛋白:胆汁盐输出蛋白(BSEP)和多药耐药蛋白3(MDR3)在肝细胞癌(n=54)、肝内胆管细胞癌(n=34)、混合性肝细胞和胆管细胞癌(n=23)及起源于肝外器官的肝样癌(rt=27)中免疫组化中的表达情况,并比较它们与精氨酸酶1(ARGl)、HepPar-1在这些肿瘤中的诊断价值。 | Fujikura K Yamasaki T Otani K 魏建国 刘勇 | 2016 | 临床与实验病理学杂志2016，32，3： | 5 |
| 5 | Image analysis of soil failure on defective underground pipe due to cyclic water supply and drainage using X-ray CT显示文摘The ground subsidence on the underground pipe often is caused with the reduction of the effective stress and the loss of suction in the base course and then,soil drainage into the pipe.The final formation of the cavity growth in the ground was observed as the ground subsidence.Authors focused this problem and hence performed model tests with water-inflow and drainage cycle in the model ground.The mechanism of cavity generation in the model ground was observed using an X-ray Computed Tomography(CT)scanner.In those studies,water was supplied into the model grounds from the defected underground pipe model in case of the change of relative density and grain size distribution.As results,it was observed that the loosening area was generated from the defected part with water-inflow and some of the soil particles in the ground were drained into the underground pipe through the defected part.And afterward,the cavity was generated just above the defected part of the model pipe in the ground.Based on this observation,it might be said that the bulk density of soil around the defected pipe played one of key factor to generate the cavity in the ground.Moreover,the dimension of the defected part should be related to the magnification of the ground subsidence,in particular,crack width on a sewerage pipe and particle size would be the quantitative factor to evaluate the magnification of the ground subsidence.In this paper,it was concluded that the low relative density of soil would become the critical factor to cause the fatal failure of model ground if the maximum grain size was close to the dimension of crack width of defective part.The fatal collapse of the ground with high relative density more than 80%would be avoided in a few cycles of water inflow and soil drainage. | Toshifumi MUKUNOKI Naoko KUMANO Jun OTANI | 2012 | Frontiers of Structural and Civil Engineering2012，6，2： | 5 |
| 6 | Characteristics of nanoparticles emitted from burning of biomass fuels显示文摘The characteristics of the particles of the smoke that is emitted from the burning of biomass fuels were experimentally investigated using a laboratory-scale tube furnace and different types of biomass fuels:rubber wood,whole wood pellets and rice husks.Emitted amounts of particles,particle-bound polycyclic aromatic hydrocarbons(PAHs)and water-soluble organic carbon(WSOC)are discussed relative to the size of the emitted particles,ranging to as small as nano-size(<70 nm),and to the rate of heating rate during combustion.differential thermal analysis(DTA)and thermogravimetric analysis(TG)techniques were used to examine the effect of heating rate and biomass type on combustion behaviors relative to the characteristics of particle emissions.In the present study,more than 30%of the smoke particles from the burning of biomass fuel had a mass that fell within a range of<100 nm.Particles smaller than 0.43μm contributed greatly to the total levels of toxic PAHs and WSOC.The properties of these particles were influenced by the fuel component,the combustion conditions,and the particle size.Although TG–DTA results indicated that the heating rate in a range of 10–20°C did not show a significant effect on the combustion properties,there was a slight increase in the decomposition temperature as heating rate was increased.The nano-size particles had the smallest fraction of particle mass and particle-bound PAHs,but nonetheless these particles registered the largest fraction of particle-bound WSOC. | Mitsuhiko Hata Jiraporn Chomanee Thunyapat Thongyen Linfa Bao Surajit Tekasakul Perapong Tekasakul Yoshio Otani Masami Furuuchi | 2014 | Journal of Environmental Sciences2014，26，9： | 5 |
| 7 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 8 | Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis显示文摘 | Iris M. Otani Arjun A. Anilkumar Robert O. Newbury Monica Bhagat Lisa Y. Beppu Ranjan Dohil David H. Broide Seema S. Aceves | 2013 | The Journal of Allergy and Clinical Immunology2013，，6： | 3 |
| 9 | A case of eosinophilic cholangitis:Imaging findings ofcontrast-enhanced ultrasonography, cholangioscopy, andintraductal ultrasonography显示文摘A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the distal common bile duct to the bifurcation of the hepatic ducts. An endoscopic plastic biliary stent was inserted; the specimen obtained from the common bile duct wall revealed dense infiltration by eosinophils. Treatment was started with prednisolone 60 mg daily. The patient's biliary stenosis and eosinophilia gradually improved. Eosinophilic infiltration in the lungs or stomach is relatively common, but it is rare in the common bile duct. Most of the reported cases of eosinophilic cholangitis presented with eosinophilia; our patient's eosinophil count was over 1000/mm3. Since our patient had allergies to pollen and house dust, a relationship between the allergies and the eosinophilic cholangitis was suspected, but no cause was identified. | Naoki Matsumoto Kiyoshi Yokoyama Kazuhiko Nakai Toshiki Yamamoto Takeshi Otani Masahiro Ogawa Naohide Tanaka Ariyoshi Iwasaki Yasuyuki Arakawa Masahiko Sugitani | 2007 | World Journal of Gastroenterology2007，13，13： | 3 |
| 10 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 3 |
| 11 | Dopaminergic modulation of synaptic plasticity in rat prefrontal neurons显示文摘The prefrontal cortex(PFC) is thought to store the traces for a type of long-term memory – the abstract memory that determines the temporal structure of behavior often termed a 'rule' or 'strategy'. Long-term synaptic plasticity might serve as an underlying cellular mechanism for this type of memory. We therefore studied the induction of synaptic plasticity in rat PFC neurons, maintained in vitro, with special emphasis on the functionally important neuromodulator dopamine. First, the induction of long-term potentiation(LTP) was facilitated in the presence of tonic/background dopamine in the bath, and the dose-dependency of this background dopamine followed an 'inverted-U' function, where too high or too low dopamine levels could not facilitate LTP. Second, the induction of long-term depression(LTD) by low-frequency stimuli appeared to be independent of background dopamine, but required endogenous, phasically-released dopamine during the stimuli. Blockade of dopamine receptors during the stimuli and exaggeration of the effect of this endogenouslyreleased dopamine by inhibition of dopamine transporter activity both blocked LTD. Thus, LTD induction also followed an inverted-U function in its dopamine-dependency. We conclude that PFC synaptic plasticity is powerfully modulated by dopamine through inverted-U-shaped dose-dependency. | Satoru Otani Jing Bai Kevin Blot | 2015 | Neuroscience Bulletin2015，31，2： | 3 |
| 12 | INHIBITION OF FARNESYL PROTEIN TRANSFERASE AND P21^(RAS) MEMEBRANE ASSOCIATION BY D-LIMONENE IN HUMAN PANCREAS TUMOR CELLS IN VITRO显示文摘INTRODUCTIONOncogenicRasproteinsarecausalyimplicatedincertainhumanmalignancies.About50%ofhumancoloncarcinomasand90%ofpancre... | Chen Xiaoguang 1 (陈晓光),Yoshihisa Yano 2, Tadayoshi Hasuma 2, Toshiko Yoshimata 2, Wang Yinna 2 and Shuzo Otani 2 1Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC, Beijing 100050 2Department of Biochemistry | 1999 | Chinese Medical Sciences Journal1999，14，3： | 3 |
| 13 | Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version显示文摘 | Toshirou Nishida Seiichi Hirota Akio Yanagisawa Yoshinori Sugino Manabu Minami Yoshitaka Yamamura Yoshihide Otani Yasuhiro Shimada Fumiaki Takahashi Tetsuro Kubota | 2008 | International Journal of Clinical Oncology2008，，5： | 2 |
| 14 | A Segmental Partial Laminectomy for Cervical Spondylotic Myelopathy: Anatomical Basis and Clinical Outcome in Comparison With Expansive Open-Door Laminoplasty显示文摘 | Koji Otani Katsuhiko Sato Shoji Yabuki Masumi Iwabuchi Shinichi Kikuchi | 2009 | Spine2009，，3： | 2 |
| 15 | Patterns of diabetic macular edema with optical coherence tomography显示文摘 | Tomohiro Otani Shoji Kishi Yasuhiro Maruyama | 1999 | American Journal of Ophthalmology1999，，6： | 2 |
| 16 | Minimally invasive surgery for gastric cancer — toward a confluence of two major streams: a review显示文摘 | Yuko Kitagawa Seigo Kitano Tetsuro Kubota Koichiro Kumai Yoshihide Otani Yoshiro Saikawa Masashi Yoshida Masaki Kitajima | 2005 | Gastric Cancer2005，，2： | 2 |
| 17 | Thermionic emission properties of boron rich LaB 6 and CeB6 crystal cathodes显示文摘 | OTANI S ISHIZAWA Y | 1996 | J Alloy Compd1996，245，12： | 2 |
| 18 | Degradation of semi-crystalline PPS bag-filter materials by NO and O 2 at high temperature显示文摘 | Winyu Tanthapanichakoon Masami Furuuchi Koh-hei Nitta Mitsuhiko Hata Shigehisa Endoh Yoshio Otani | 2006 | Polymer Degradation and Stability2006，，8： | 2 |
| 19 | A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma显示文摘 | Shigeyuki Takeshita Tatsuki Ichikawa Kazuhiko Nakao Hisamitsu Miyaaki Hidetaka Shibata Toshihisa Matsuzaki Toru Muraoka Takuya Honda Masashi Otani Motohisa Akiyama Satoshi Miuma Esuke Ozawa Masumi Fujimito Katsumi Eguchi | 2009 | Nutrition Research2009，，2： | 2 |
| 20 | Diagnosis and Treatment of a Gastric Hamartomatous Inverted Polyp: Report of a Case显示文摘 | Masahiko Aoki Masashi Yoshida Yoshiro Saikawa Yoshihide Otani Tetsuro Kubota Koichiro Kumai Go Wakabayashi Tai Omori Makio Mukai Masaki Kitajima | 2004 | Surgery Today2004，，6： | 2 |
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