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| 1 | Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden's disease显示文摘Cowden's disease, one of the several hamartoma syndromes, is characterized by hyperplastic lesions and hamartomas distributed in the whole body. About thirty percent of patients with Cowden's disease have been reported to be complicated by malignant tumors. Based on the criteria of the International Cowden Consortium, this disease is mainly diagnosed as trichilemmoma of the face and oral mucosal papillomatosis. However, Cowden's disease patients themselves often do not recognize trichilemmoma of the face and oral mucosal papillomatosis. We report a case of Cowden's disease in a 33-year-old female patient who was diagnosed based on the characteristic findings at gastrointestinal endoscopy. Clinically, the patient was aware of having bloody stools. Multiple polyps found endoscopically in the esophagus, stomach, ileum, colon and rectum showed histopathologically hamartomatous changes and epithelial hyperplasia. Physical examination revealed oral papillomatosis and facial trichilemmomas. A germline mutation in exon 8 of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene was found in this case. It was a point mutation of C to T at codon 1003 (CGA→TGA, arginine→stop codon). The characteristic findings on gastrointestinal endoscopy led us to a diagnosis of Cowden's disease. It has been reported that gastrointestinal polyposis with esophageal polyposis is found in about 85.7% of Japanese patients with Cowden's disease. The characteristic findings on gastrointestinal endoscopy can be a useful diagnostic clue to Cowden's disease. | Ken Umemura Sho Takagi Yasushi Ishigaki Masahiro Iwabuchi Shigeru Kuroki Yoshitaka Kinouchi Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，37： | 6 |
| 2 | Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats显示文摘AIM:To elucidate the role of neuropilin-1(Nrp-1) and semaphorin 3A(Sema3A) in sinusoidal remodeling during liver regeneration in rats.METHODS:Male Wistar/ST rats at 7 wk of age,weighing about 200 g,were used for all animal experiments.In vivo,at 24,48,72,96,144 and 192 h after twothirds partial hepatectomy(PHx),the remnant livers were removed.Liver tissues were immunohistochemically stained for Nrp-1,Sema3A and SE-1,a liver sinusoidal endothelial cell(SEC) marker.Total RNA of the liver tissue was extracted and reversely transcribed into cDNA.The mRNA expression of Sema3A was analyzed by quantitative real-time polymerase chain reaction and normalized to that of ribosomal protein S18.In vitro,SECs were isolated from rat liver and cultured in endothelial growth medium containing 20 ng/mL vascular endothelial cell growth factor.Migration of SECs in primary culture was assessed by cell transwell assay with or without recombinant Sema3A.Apoptotic cells were determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling method.RESULTS:In vitro,immunohistochemistry study revealed that Sema3A and Nrp-1 were constitutively expressed in hepatocytes and SECs,respectively,in normal rat liver tissues.Nrp-1 expression in SECs was quantified by the percentage of immunostained area with antiNrp-1 antibody in relation to the area stained with SE-1.Between 24 h and 96 h following resection of liver,Nrp-1 expression in SECs was transiently increased.Compared with the baseline(5.2% ± 0.1%),Nrp-1 expression in SECs significantly increased at 24 h(17.3% ± 0.7%,P < 0.05),48 h(39.1% ± 0.6%,P < 0.01),72 h(46.9% ± 4.5%,P < 0.01) and 96 h(29.9% ± 3.8%,P < 0.01) after PHx,then returned to the basal level at termination of liver regeneration.Interestingly,the expression of Sema3A was inversely associated with that of Nrp-1 in liver after PHx.Sema3A mRNA expression was significantly reduced by about 75% over the period 24-144 h after PHx(P < 0.05),and returned to basal levels at 192 h after PHx.In vitro,SECs isolated from rats after PHx(PHx-SECs) were observed to migrate to the lower chamber of the cell transwell system after incubation for 24 h,but not cells from normal rats(CONT-SECs),indicating that mobility of PHx-SECs increases as compared with that of CONT-SECs.Moreover,recombinant Sema3A significantly attenuated migration in PHx-SECs in primary culture(vehicle-treated 100% ± 7.9% vs Sema3A-treated 42.6% ± 5.4%,P < 0.01),but not in CONT-SECs.Compared with CONTSECs,the apoptotic rate of PHx-SECs decreased by 78.3%(P < 0.05).There was no difference in apoptosis between CONT-SECs that were treated with vehicle and Sema3A.However,in PHx-SECs,apoptosis was induced by the presence of 5 nmol Sema3A for 24 h(vehicle-treated 21.7% ± 7.6% vs Sema3A-treated 104.3% ± 8.9%,P < 0.05).In addition,immunohistochemistry confirmed the increased expression of Nrp-1 in PHx-SECs,while it was noted to a lesser extent in CONT-SECs.CONCLUSION:The interplay of Nrp-1 and Sema3A shown in our results may lead to a better understanding of interaction between sinusoidal remodeling and SECs during liver regeneration. | Ling Fu Tsuneo Kitamura Kazuhisa Iwabuchi Syozo Ichinose Mitsuaki Yanagida Hideoki Ogawa Sumio Watanabe Toshihide Maruyama Masafumi Suyama Kenji Takamori | 2012 | World Journal of Gastroenterology2012，18，36： | 5 |
| 3 | A Segmental Partial Laminectomy for Cervical Spondylotic Myelopathy: Anatomical Basis and Clinical Outcome in Comparison With Expansive Open-Door Laminoplasty显示文摘 | Koji Otani Katsuhiko Sato Shoji Yabuki Masumi Iwabuchi Shinichi Kikuchi | 2009 | Spine2009，，3： | 2 |
| 4 | 柴油机新型燃烧系统的研究——预混合压缩着火燃烧显示文摘研究了一种高效低排放的稀混合燃烧——预混合压缩着火(PCI)燃烧系统,阐述了其优点及存在的问题。在PCI燃烧系统中,早在压缩行程就将燃油喷入燃烧室,经过较长时间的混合形成预混合稀混合气。试验发动机就由这种预混合的稀混合气自行着火燃烧而工作,从对燃烧的观察和数值模拟的结果可见,有必要防止油束附着在气缸壁和燃烧室壁上。因此,制造了低贯穿距的冲击-雾化油嘴并进行了试验。结果表明,可以实现很低的NO_x排放,燃油耗却增加很少,同时也发现PCI燃烧的发动机工作范围限制在部分负荷工况内,并引起HC排放增加。然而,由于它能获得放热等容度高的燃烧特性,因此,PCI燃烧系统可能代表着比传统柴油机更有效、更清洁的燃烧系统(超低NO_x和低烟度)。 | Yoshinori Iwabuchi Kenji Kawai Takeshi Shoji 姬芬竹 | 2002 | 国外内燃机2002，34，6： | 2 |
| 5 | High temperature fretting wears of four-titanium alloys显示文摘 | Waterhouse R B Iwabuchi A | 1985 | wear1985，106，： | 2 |
| 6 | Electrophysiological features of central motor conduction in spinocerebellar atrophy type 1,type 2,and Machado-Joseph disease显示文摘 | Yokota T Sasaki H Iwabuchi K | 1998 | Neurology Neurosurgery & Psychiatry1998，65，4： | 1 |
| 7 | Biotransformation cf pravastatin sodium(Ⅰ):mechanisms of enzymic transformation and epimerizationof an allylic hydroxy group of pravastatin sodium显示文摘 | KITAZAWA E TAMURA N IWABUCHI H | 1993 | Biochem Biophys Res Commun1993，192，： | 1 |
| 8 | Diffusion-weighted imaging of malignant breast tumors : the usefuless of apparent diffusion coefficient (ADC) value and ADC map for detection of malignant breast tumors and evaluation of cancer extension 显示文摘 | Woodhams R Mastsunaga K Iwabuchi K | 2005 | J Comput Assit Tomogr2005，29，5： | 1 |
| 9 | Central effects of fexofenadine and cetirizine:measurement of psychomotor performance, subjective sleepiness, and brain histamine HI-receptor occupancy using 11C-doxepin positron emission tomography 显示文摘 | Tashiro M Sskurada Y Iwabuchi K | 2004 | J Clinic Pharmacology2004，44，8： | 1 |
| 10 | Epithelial cell- derived human beta- defensin- 2 acts as a chemotaxin for mast ceils through a pertussis toxin-sensitive and phospho- lipase C-dependent pathway 显示文摘 | Niyonsaba F Iwabuchi K Matsuda H | 2002 | Int Immunol2002，14，4： | 1 |
| 11 | Diffusion- weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension显示文摘 | Woodhams R Matsunaga K Iwabuchi K | 2005 | J Comput Assist Tomogr2005，29，5： | 1 |
| 12 | Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis显示文摘 | Hatano Y Kasama T Iwabuchi H | 1999 | Ann Rheum Dis1999，58，5： | 1 |
| 13 | Bilateral facial nerve palsy and appendicitis occurring during acute retroviral syndrome显示文摘 | Morioka H Sakamoto N Iwabuchi S | 2014 | Intern Med2014，53，2： | 1 |
| 14 | Serum level of macrophage migration inhibitory factor as auseful parameter of clinical course in patients with Wegener′s granulomatosis and relapsing polychondritis显示文摘 | Ohwatari R Fukuda S Iwabuchi K | 2001 | Ann Otol Rhinol Laryngol2001，110，： | 1 |
| 15 | Nationwide survey ofSalmonella prevalence in environmental dust from layer farms in Japan 显示文摘 | IWABUCHI E MARUYAMA N HARA A | 2010 | Journal of Food Protection2010，73，11： | 1 |
| 16 | Application of potential pulse method to the corrosion behavior of the fresh surface formed by scratching and sliding in corrosive wear显示文摘 | Iwabuchi A Sonoda T Yashiro H | 1999 | Wear1999，226，： | 1 |
| 17 | Binding of laminin-1 to monosialoganglioside GMI in lipid rafts is crucial for neurite outgro- wth显示文摘 | Ichikawa N Iwabuchi K Kurihara H | 2009 | J Cell Sci2009，122，2： | 1 |
| 18 | Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA显示文摘 | Daiju Iwata Mizuki Kitamura Nobuyoshi Kitaichi Yoshinari Saito Shigeyuki Kon Kenichi Namba Junko Morimoto Akiko Ebihara Hirokuni Kitamei Kazuhiko Yoshida Susumu Ishida Shigeaki Ohno Toshimitsu Uede Kazunori Onoé Kazuya Iwabuchi | 2009 | Experimental Eye Research2009，，1： | 1 |
| 19 | Third-line chemotherapy with paclitaxel,irinotecan hydrochloride and cisplatin for recurrent gastric cancer:a case report 显示文摘 | Takahashi N Suzuki H Iwabuchi S | 2005 | Hepatogastroenterology2005，52，61： | 1 |
| 20 | Determination of glycinin and β- conglycinin in soybean proteins by immunological methods显示文摘 | IWABUCHI S YAMUCHI F | 1987 | J Agric Food Chem1987，35，： | 1 |
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