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| 1 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 3 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 4 | Student digital information-seeking behavior in context显示文摘 | Nicholas D Huntington P Jamali H R Rowlands I Fieldhouse M | 2009 | Journal of Documentation2009，65，1： | 1 |
| 5 | Remote instrument diagnosis on the internet显示文摘 | Nicholas H M C Bernard B C David M H | 1998 | IEEE Intelligent System & Their Application1998，13，3： | 1 |
| 6 | Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones显示文摘 | Piyasena H Nicholas A M | 1993 | Bioorg & Med Chem Lett1993，3，12： | 1 |
| 7 | Volatile organic compounds (VOCs) emitted from 40 Mediterranean plant species: VOCs speciation and extrapolation to habitat scale 显示文摘 | Susan M O Christophe B Nicholas H C | 2001 | Atmospheric Environment2001，35，32： | 1 |
| 8 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 9 | Synorogenic hydrothermal origin forgiant Hamersley iron oxide ore bodies显示文摘 | Christopher M P Nicholas H S | 1999 | Geology1999，27，2： | 1 |
| 10 | Shape intrinsic properties for free-form object matching显示文摘 | KO K H TAKASHI M NICHOLAS M P | 2003 | Journal of Computing and Information Science in Engineering2003，3，4： | 1 |
| 11 | Role of Respiratory Viruses in Acute Upper and Lower Respiratory Tract Illness in the First Year of Life显示文摘 | Merci M H Mbbs K Nicholas H | 2006 | Pediatr Infect Dis J2006，25，： | 1 |
| 12 | Interstitial chemo therapy with drug polymer implants for the treatment of recurrent gliomas显示文摘 | BREM H MAHALTY M S NICHOLAS A V | 1991 | J Neurosurg1991，74，6： | 1 |
| 13 | Cortamidine Oxide,a Novel Disulfide Metabolite from the New Zealand Basidiomycete (Mushroom) Cortinarius Species显示文摘 | Nicholas G M Blunt J W Munro M H G | | 0，，03： | 1 |
| 14 | Diagenesis of a tight gas sand reservoir: Upper Cretaceous Mesaverde Group, Piceance Basin, Colorado 显示文摘 | Trevor M S Nicholas B H Crawford W E | 2013 | Marine and Petroleum Geology2013，40，6： | 1 |
| 15 | Role of Respiratory Viruses in Acute Upper and Lower Respiratory Tract Illnessin the First Year of Life显示文摘 | Merci M H Mbbs K Nicholas H | 2006 | Pediatric Infectious Disease2006，，： | 1 |
| 16 | Methylbenzene chemislry on zeolite HBeta: Multiple insights into methanol-to-olefin catalysis显示文摘 | SASSI A WlLDMAN M A AHN H J PRASAD P NICHOLAS J B HAW J F | 2002 | J Phys Chem B2002，106，9： | 1 |
| 17 | Is timely information always better the effect of feedback frequency on decision making显示文摘 | NICHOLAS H L SWAMINATHAN M J | 2009 | Organizational Behavior and Human Decision Processes2009，108，2： | 1 |
| 18 | The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis显示文摘 | Anand H Patel Denise M Harnois George G Klee Nicholas F LaRusso Gregory J Gores | 2000 | The American Journal of Gastroenterology2000，，1： | 1 |
| 19 | Synorogenic hydrothermal origin forgiant Hamersley iron oxide ore bodies显示文摘 | Christopher M P Nicholas H S | 1999 | Geology1999，27，2： | 1 |
| 20 | Edge-to-edge (Alfieri) mitral repair: results in diverse clinical settings显示文摘 | Sunil K Bhudia Patrick M McCarthy Nicholas G Smedira Buu-Khanh Lam Jeevanantham Rajeswaran Eugene H Blackstone | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
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