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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 12 |
| 3 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 2 |
| 4 | Activation of peroxisome proliferator-activated receptor:α decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes 显示文摘 | YOKO I T TAKASHI M YOSHITOSHI K | 2004 | J Cardiovasc Pharmacol2004，44，1： | 1 |
| 5 | Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10 显示文摘 | Takashi M | 2009 | International Journal of Pharmaceutics2009，378，12： | 1 |
| 6 | Multivariate evaluation of factors affecting recurrence,progression,and survival in patients with superficial bladder cancer(Tokyo 172 strain)therapy:significance of concomitant carcinoma in situ显示文摘 | Takashi M Wakai K Hattori T | 2002 | Int Urol Nephrol2002，33，： | 1 |
| 7 | Cutting process of glass with inclined ball end mill 显示文摘 | Takashi M Takenori O | 2008 | Journal of Materials Processing Technology2008，200，123： | 1 |
| 8 | Spinal cord compression due to ossification of ligament:MR imaging显示文摘 | Yamashita Y Takashi M Matsuno Y | 1990 | Radiology1990，175，： | 1 |
| 9 | Novel interaction of the voltage-dependent sodium channel (VDSC) with calmodulin: does VDSC acquire calmodulin-mediated Ca2+-sensitivity?显示文摘 | Masayuki M Takashi K Takeaki O | 2000 | Biochemistry2000，39，6： | 1 |
| 10 | PPAR-γ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein显示文摘 | Maeda N Takashi M Funahashi T | 2001 | Diabetes2001，50，9： | 1 |
| 11 | Subacuteosteomyelitis of long bones diagnostic usefulness of the 'penumbra sign' on MRI 显示文摘 | TAKASHI M TETSUJI Y | 2002 | J Clin Imag2002，26，： | 1 |
| 12 | Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma : An ultrarapid de- tection system for intraperitoneal free cancer ceils and a prophylactic strat- egy for peritoneal metastasis 显示文摘 | Takashi M Shinya S Keaji S | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 13 | Japanese Corporate Govern- ance: Structural Change and Financial Performance 显示文摘 | sli M C Torn Y Takashi H | 2007 | Asian Business & Management2007，，6： | 1 |
| 14 | Lithiation characteristics of FeVO4 显示文摘 | Masatoshi H Mika E Takashi M | 1997 | Solid State Ionics1997，98，： | 1 |
| 15 | Anti-endothelial cell antibodies in patients with interstitial lung diseases显示文摘 | Takashi M Naoki I Takafumi S | 2008 | Respiratory Medicine2008，102，： | 1 |
| 16 | New Index for the stability of a type I collagen affected by hydrophobic environment显示文摘 | TAKASHI N TOMOHIRO M KAORI S | 2007 | Detal Materials2007，26，3： | 1 |
| 17 | PPAR-gamma lig- ands increase expression and plasma concentrations of adi- ponectin, an adipose-derived protein显示文摘 | Maeda N Takashi M Funahashi T | 2001 | Diabetes2001，50，9： | 1 |
| 18 | Application of a newly designed right -sided, double -lumen endobronchial tube in patients with a very short right mainstem bronchus 显示文摘 | Satoshi H Masaki T Takashi M | 2008 | Anesthesiology2008，109，3： | 1 |
| 19 | Characteristics of overland flow generation on steep forested hillslopes of central Japan显示文摘 | Takashi G Roy C S Ueno M | 2008 | Journal of Hydrology2008，361，34： | 1 |
| 20 | Effects of dual endothelin receptor antagonist on antiapoptotic marker bcl-2 expression in streptozotocin-induced diabetic rats 显示文摘 | Takashi M Subrina J Sohel Z | 2006 | Exp Biol Med2006，231，6： | 1 |
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