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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | 软组织肉瘤术后局部复发因素分析显示文摘目的探讨软组织肉瘤(soft tissue sarcoma,STS)患者术后局部复发的因素。方法回顾分析1995年至2010年,英国爱丁堡皇家医院手术治疗的79例STS患者的随访结果。男44例,女35例;年龄18-97岁,平均62.9岁。79例随访6-139个月,平均41个月。组织学诊断由2名隶属于英国国家组织病理学专家组的成员来确定。肿瘤分级按Trojani分级评定。Trojani 1级定义为低度恶性,Trojani 2级和3级定义为高度恶性。阳性外科边界的标准是,在组织学切片上,发现切除边缘任何部位存在肿瘤细胞。结果本组79例中,21例阳性边界者14例复发,7例未复发;58例阴性边界者9例复发,49例未复发(P〈0.0001,OR=10.9)。53例高度恶性者20例复发,33例未复发;26例低度恶性者,3例复发,23例未复发(P=0.016,OR=4.6)。43例进行辅助治疗者19例复发,24例未复发;36例非辅助治疗者4例复发,32例未复发(P=0.001,OR=6.3)。17例肿瘤转移者8例复发,9例未复发;62例未转移者15例复发,47例未复发(P=0.07,OR=2.8)。肿瘤组织学分级、阳性边界和是否进行辅助治疗是局部复发的相关因素;肿瘤是否转移与局部复发无相关性。高度恶性肿瘤是低度恶性肿瘤的5.2倍,阳性边界是阴性边界的3.3倍,是导致局部复发的独立危险因素。结论外科边界和肿瘤组织学级别是导致局部复发的最重要影响因素。高度恶性肿瘤患者的阳性边界通常会提高肿瘤的复发几率。 | 江军 Oliver Peck Nicholas D Clement Daniel Edward Porter | 2015 | 中国骨与关节杂志2015，4，7： | 3 |
| 3 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 4 | After Administration of Intravenous Epinephrine for bee Sting-induced Anaphylaxis: Kounis Syndrome or Epinephrine Effect?显示文摘To the Editor: In the very important report published in Chinese Medical Journal,[1] a 50-year-old male patient, stented with a bare metal stent followed by 3 overlapping drug-eluting stents, developed anaphylactic reaction following a bee sting that was treated with intravenous 0.1 mg epinephrine at a 1:100,000 together with intravenous methylprednisolone, chlorpheniramine maleate, and ranitidine.He developed, immediately after, an anterior wall myocardial infarction, and subsequent coronary arteriography revealed total occlusion in the proximal left anterior descending stent and 90% stenosis with tissue growth in the mid-stent.The authors concluded that the acute myocardial infarction occurred due to acute stent thrombosis caused by exogenous epinephrine administration.This report, however, raises important questions related to the cause and pathophysiology of these events. | Nicholas G Kounis George D Soufras Dimitrios Lianas Nicholas Patsouras | 2016 | Chinese Medical Journal2016，，4： | 2 |
| 5 | 胸腹主动脉瘤:杂交修复术结果显示文摘目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经验。方法:从2005年3月—2012年6月间58名患者在单中心接受解剖外内脏血管去分支化及随后的动脉瘤腔内隔绝术。内脏旁路的中位数为4支,最初的33例采用同期手术方式,而最近的25例采用分期手术。结果:患者中位年龄为69.0岁,50%为女性,所有患者存在严重合并症而不适合传统开放修复术。平均主动脉直径(6.7±1.2)cm,30 d/住院病死率、脑卒中率、永久性轻瘫/截瘫率分别为9%、0%以及4%。最近25例分期手术患者的这三种并发症率分别为4%、0%以及0%。平均随访时间(26±21)个月,内脏人工血管通畅率95.3%,所有闭塞的内脏人工血管均为肾动脉,无1例引起永久性截瘫,2例患者需再干预,1例出现Ib型内漏,1例出现III型内漏,5年免于再干预率为94%,Kaplan-Meier总体生存率为1年78%、5年62%,5年主动脉相关生存率为87%。结论:这些更新后的结果 ,继续支撑着这一观点:运用完全内脏动脉去分支联合动脉瘤腔内隔绝的杂交技术治疗高龄且不适合传统开放手术的高危TAAA患者是一种理想的选择,而采取分期手术的方式能取得更佳的结果。 | Gchad Hughes Nicholas D Andersen Jennifer M Hanna Richard L McCann 老启芳 | 2015 | 中国普通外科杂志2015，24，6： | 2 |
| 6 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 7 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 8 | Exploratory bioavailability and pharmacokinetic studies of sulphadime-thoxine and ormetoprim in the penaeid shrimp, Penaeus vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，： | 1 |
| 9 | Mycoplasma infections in growing cattle 显示文摘 | NICHOLAS R A J BAKER S AYLING R D | 2000 | Cattle Practice2000，，8： | 1 |
| 10 | Friction stir welding for the transportation industries 显示文摘 | Thomas W M Nicholas E D | 1997 | Materials and Design1997，18，6： | 1 |
| 11 | 显示文摘 | Alan D W Nicholas HH Yewlan W | 1999 | EMBO J1999，18，8： | 1 |
| 12 | Autoantigen based vac- cines for type 1 diabetes显示文摘 | Nicholas D Odumosu O Langridge W H | 2011 | Discov Med2011，11，59： | 1 |
| 13 | Using the Cancer Rehabilitation Questionnaire in patients with colo- rectal cancer显示文摘 | Nicholas P K Leuner J D Hatfield J M | 2006 | Rehabil Nurs2006，31，3： | 1 |
| 14 | Blind high resolution localization and tracking of multiple frequency hopped signals显示文摘 | Liu X Q Nicholas D S Swami A | 2002 | IEEE Transactions on Signal Processing2002，50，4： | 1 |
| 15 | Researchers' e-journal use and information seeking behavior显示文摘 | Nicholas D Williams P Rowlands I Jamali H R | 2010 | Journal of Information Science2010，，36： | 1 |
| 16 | A brief review of the past,present and future of wood preservation显示文摘 | SCHULTA T Nicholas D Preston A | 2007 | Pest Management Science2007，63，8： | 1 |
| 17 | Pterygia pathogenesis : corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells 显示文摘 | Nicholas D Molykutty K J Gregory SS | 2001 | Arch Ophthalmol2001，119，5： | 1 |
| 18 | Effectual Versus Predictive Logics in Entrepreneur-ial Decision-making:Differences between Expertsand Novices显示文摘 | NICHOLAS D STUART R SARAS D S | 2008 | Journal of Business Venturing2008，26，3： | 1 |
| 19 | Mycoplasma host specificity: fact or fiction? 显示文摘 | Pitcher D G Nicholas R A | 2005 | Vet J2005，170，： | 1 |
| 20 | Diameter-selective encapsulation of metallocenes in single walled carbon nanotubes 显示文摘 | Li L J Khlobystov A N Wiltshire J G Briggs G A D Nicholas R J | 2005 | Nature Materials2005，4，： | 1 |
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