|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 2 | Bone marrow stromal cells as targets for gene therapy of hemophilia A显示文摘 | Chuah MK Brems H Vanslembrouck V | 1998 | Hum Gene Ther1998，9，3： | 1 |
| 3 | Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas显示文摘 | BREM H MAHALEY MS VICK NA | 1991 | J Neurosurg1991，74，2： | 1 |
| 4 | The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers显示文摘 | Brem H Lawson HC | 1999 | Cancer1999，86，2： | 1 |
| 5 | Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470 显示文摘 | O' Reilly M Brem H Folkman J | 1995 | J Pediatr Surg1995，30，2： | 1 |
| 6 | Cellular and molecular basis of wound healing in diabetes显示文摘 | Brem H Tomic-Canic M | 2007 | J Clin Invest2007，117，5： | 1 |
| 7 | Molecular pathogenesis of chronic wounds: the role of beta- catenin and c mycin the inhibition of epithelialization and wound healing 显示文摘 | STOJADINOVIC O BREM H VOUTHOUNIS C | 2005 | Am J Pathol2005，167，1： | 1 |
| 8 | Evidence- based protocol for diabetic foot ulcers 显示文摘 | Brem H Sheehan P Rosenberg H J | 2006 | Plast Reconstr Surg2006，117，7： | 1 |
| 9 | Glenoid size inclination and version :an anatomic study显示文摘 | Churchill RS Brems JJ Kotschi H | 2001 | J Shoulder Elbow Surg2001，10，4： | 1 |
| 10 | The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers 显示文摘 | Brem H Lawson H C | 1999 | Cancer1999，86，2： | 1 |
| 11 | Evidence - based protocol for diabetic foot ulcers 显示文摘 | Brem H Sheehan P Rosenberg H J | 2006 | Plast Reconstr Surg2006，，： | 1 |
| 12 | Facial nerve injury in acoustic neuromas (vestibular schwannoma) surgery: etiology and prevention 显示文摘 | Sampath P Holliday MJ Brem H | 1997 | J Neurosurg1997，87，1： | 1 |
| 13 | Protocol for the treatment of diabetic foot ulcers 显示文摘 | Brem H Sheehan P Bouhon AJ | 2004 | Am J Surg2004，187，5： | 1 |
| 14 | Advancing the field of drug delivery: taking aim at cancer 显示文摘 | Moses M A Brem H Langer R | 2003 | Cancer Cell2003，4，5： | 1 |
| 15 | Prolonged tumor dormancy by prevention of neovascularization in the vitreous显示文摘 | Brem S Brem H Folkman J | 1976 | Cancer Res1976，36，8： | 1 |
| 16 | The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable potymers显示文摘 | Lawson HC | 1999 | Cancer1999，86，2： | 1 |
| 17 | In Vivo Versus in vitro Degradation of Controlled Release Polymers for Intracranial Surgical Therapy显示文摘 | Wu M P Tamada J A Brem H | 1994 | J Biomed Mater Res1994，28，： | 1 |
| 18 | Plane stress yield function for aluminum alloy sheets (Part I):Theory显示文摘 | BARLAT F BREM J C YOON J W CHUNG K DICK R E LEGE D J POURBOGHRAT F CHOI S H CHU E | 2003 | Int J Plasticity2003，19，： | 1 |
| 19 | Implantable slow-release chemotherapeutic polymer for the treatment of malignant brain tumors 显示文摘 | Sampath P Brem H | 1998 | Cancer Control1998，5，2： | 1 |
| 20 | Bone marrow stromal cells as targets for gene therapy of hemophilia A显示文摘 | Chuah MK Brems H Vanslembrouck V | 1998 | Hum Gene Ther1998，9，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员