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| 1 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 4 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 5 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 6 | Sources of Conflict between Work and Family Roles显示文摘 | GREENHAUS J H NICHOLAS J B | 1985 | Academy of Management Review1985，10，1： | 1 |
| 7 | Autoantigen based vac- cines for type 1 diabetes显示文摘 | Nicholas D Odumosu O Langridge W H | 2011 | Discov Med2011，11，59： | 1 |
| 8 | Abundance and natural control of the woolly aphid Eriosoma lanigerum in an Australian apple orchard IPM program显示文摘 | Nicholas A H Spooner-- Hart R N Vickers R A | 2005 | BioControl2005，50，2： | 1 |
| 9 | Researchers' e-journal use and information seeking behavior显示文摘 | Nicholas D Williams P Rowlands I Jamali H R | 2010 | Journal of Information Science2010，，36： | 1 |
| 10 | Distillation with secondary reflux and vaporization: a comparative evaluation 显示文摘 | Mah R S H Nicholas J J Wodnik R B | 1977 | AIChE J1977，23，5： | 1 |
| 11 | Characterization of inclusion complexes of betamethasone - related steroids with cy- clodextrins using high- performance liquid chromatography显示文摘 | Keith G F Eugene R R Nicholas H S | 2000 | Chromatography A2000，903，12： | 1 |
| 12 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 13 | Student digital information-seeking behavior in context显示文摘 | Nicholas D Huntington P Jamali H R Rowlands I Fieldhouse M | 2009 | Journal of Documentation2009，65，1： | 1 |
| 14 | Prevalence and Predictors of Acute Stress Disorder and PTSD Following Road Traffic Accidents:Thought Control Strategies and Social Support:Special Series:On Understanding the Persistence of Depressive and Anxious Thinking显示文摘 | Vassiliki H Nicholas T Adrian W | 2001 | Behav Ther(S0005-7894)2001，32，1： | 1 |
| 15 | Temperature and the expression of myogenic regulatory factors(MRFs) and myosin heavy chain isoforms during embryogenesis in the com- mon carp Cyprinus carpin L显示文摘 | Nicholas J Thomas E H Christopher L | 2004 | J Expel Biol2004，207，24： | 1 |
| 16 | Remote instrument diagnosis on the internet显示文摘 | Nicholas H M C Bernard B C David M H | 1998 | IEEE Intelligent System & Their Application1998，13，3： | 1 |
| 17 | Reconstruction of the coracoclavicular ligaments with tendon grafts: a comparative biomechanical study显示文摘 | Lee S J Nicholas S J Akizuki K H | 2003 | Am J Sports Med2003，31，5： | 1 |
| 18 | Web-based knowledge management for distributed design显示文摘 | NICHOLAS H CALD W | 2000 | IEEE Intelligent System2000，3，7： | 1 |
| 19 | Head-space analysis in moderngas chromatography显示文摘 | Nicholas H Snow Gregory C Slack | 2002 | Trends Analyt Chem2002，21，910： | 1 |
| 20 | Postoperative Pain Control for Total Knee Arthroplasty: Continuous Femoral Nerve Block Versus Intravenous Patient Controlled Analgesia 显示文摘 | Rui ML John BL Nicholas H | 2012 | Anesth Pain IVied2012，1，4： | 1 |
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