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| 1 | 北美神经内分泌肿瘤学会和核医学与分子影像学会有关177Lu-DOTATATE肽受体放射性核素治疗患者选择和合理应用共识显示文摘随着177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)肽受体放射性核素治疗(PRRT)的日益普及,有关患者合理选择的问题日益增多。该文回顾了有关177Lu-DOTATATE在不同原发性神经内分泌肿瘤(NETs)中的应用文献,讨论了一些有争议的问题,并回顾了治疗的潜在禁忌证。此共识是由北美神经内分泌肿瘤学会(NANETS)和核医学与分子影像学会(SNMMI)共同制定的。NANETS是成立于2005年的北美多学科神经内分泌专家专业学会,目的在于通过增加研究和教育机会改善对NETs的管理。NANETS致力于多学科研究,由NETs涉及的不同专业的医师和科学家组成。SNMMI成立于1954年,旨在促进核医学科学、技术和实践应用的国际性科学专业组织,除了出版期刊、时事通讯和书籍外,还主办提高核医学从业人员能力和促进核医学科学新发展的国际会议及讲习班。 | 邓艳(译) 张伟(审校) Thomas A.Hope Lisa Bodei Jennifer A.Chan Ghassan El-Haddad Nicholas Fidelman Pamela L.Kunz Josh Mailman Yusuf Menda David C.Metz Erik S.Mittra Daniel A.Pryma Diane L.Reidy-Lagunes Simron Singh Jonathan R.Strosberg | 2020 | 中华核医学与分子影像杂志2020，40，11： | 11 |
| 2 | Multi-responsive hydrogels for drug delivery and tissue engineering applications显示文摘Multi-responsive hydrogels,or‘intelligent’hydrogels that respond to more than one environmental stimulus,have demonstrated great utility as a regenerative biomaterial in recent years.They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli.As evidenced by a burgeoning number of investigators,multi-responsive hydrogels are endowed with tunable,controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications.This article encompasses recent developments and challenges regarding supramolecular,layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering. | Jennifer M.Knipe Nicholas A.Peppas | 2014 | Regenerative Biomaterials2014，1，1： | 5 |
| 3 | Competitive metabolism of L-arginine:arginase as a therapeutic target in asthma显示文摘Exhaled breath nitric oxide (NO) is an accepted asthma biomarker.Lung concentrations of NO and its amino acid precursor,L-arginine,are regulated by the relative expressions of the NO synthase (NOS) and arginase isoforms.Increased expression of arginase I and NOS2 occurs in murine models of allergic asthma and in biopsies of asthmatic airways.Although clinical trials involving the inhibition of NO-producing enzymes have shown mixed results,small molecule arginase inhibitors have shown potential as a therapeutic intervention in animal and cell culture models.Their transition to clinical trials is hampered by concerns regarding their safety and potential toxicity.In this review,we discuss the paradigm of arginase and NOS competition for their substrate L-arginine in the asthmatic airway.We address the functional role of L-arginine in inflammation and the potential role of arginase inhibitors as therapeutics. | Jennifer M.Bratt Amir A.Zeki Jerold A.Last Nicholas J.Kenyon | 2011 | The Journal of Biomedical Research2011，25，5： | 5 |
| 4 | Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction显示文摘到神经原的精力供应的损失在击期间导致被称为缺氧的去极的膜潜力的快速的损失。因为离子的流动的 dysregulation 和 ATP 的损失,缺氧的去极在神经原上导致巨大的生理的应力驾驶维持电气化学的坡度的离子泵。在这评论,我们在场一些被认为贡献神经原并且随后的缺氧的去极的 ionotropic 受体和离子隧道的概述,到房间死亡。为作为门 ligand 的阳离子隧道工作的 glutamate 和 ATP 的 ionotropic 受体在神经原的死亡和机能障碍是批评的。有趣地,二这些受体(P2X7 和 NMDAR ) 被显示了联合离子隧道到 pannexin-1 (Panx1 ) 。我们也讨论短暂受体潜力(TRP ) 的重要角色响应局部缺血的隧道和酸察觉到的离子隧道(ASIC ) 。从我们缺氧的去极的当前的理解出现的中央挑战是需要阐明这些离子隧道到的机械学、时间的相互关系充分在击期间在神经原上欣赏他们的影响。 | Nicholas L WEILINGER Valentyna MASLIEIEVA Jennifer BIALECKI Sarup S SRIDHARAN Peter L TANG Roger J THOMPSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 5 |
| 5 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 6 | Predictors of double balloon endoscopy outcomes in the evaluation of gastrointestinal bleeding显示文摘AIM:To identify patients' characteristics associated with double balloon endoscopy(DBE)outcomes in investigation of obscure gastrointestinal bleeding(OGIB).METHODS:Retrospective study performed at an academic tertiary referral center.Evaluated endpoints were clinical factors associated with no diagnostic yield or non-therapeutic intervention of DBE performed for OGIB evaluation.RESULTS:We included fifty-five DBE between August 2010 and April 2012.The mean age of the sample was 67 with 32 males(58.2%).Twenty-four DBE had no diagnostic yield and 30 DBE did not require therapy.Non-diagnostic yield was associated with performing two or more DBE studies in one day [odds ratio(OR):13.72,P=0.008],absence of blood transfusions within a year of the DBE(OR:7.16,P=0.03)and absence of ulcers or arteriovenous malformations(AVMs)on prior esophagogastroduodenoscopy(EGD)or colonoscopy(OR:19.30,P=0.033).Non-therapeutic DBE was associated with performing two or more DBE per day(OR:18.579,P=0.007),gastrointestinal bleeding episode within a week of the DBE(OR:11.48,P=0.003),fewer blood transfusion requirements prior to DBE(OR:4.55,P=0.036)and absence of ulcers or AVMs on prior EGD or colonoscopy(OR:8.47,P=0.027).CONCLUSION:Predictors of DBE yield and therapeutic intervention on DBE include blood transfusion requirements,previous endoscopic findings and possibly endoscopist fatigue. | Hisham Hussan Nicholas R Crews Caroline M Geremakis Soubhi Bahna Jennifer L LaBundy Christine Hachem | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 3 |
| 7 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，7： | 2 |
| 8 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，： | 2 |
| 9 | 胸腹主动脉瘤:杂交修复术结果显示文摘目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经验。方法:从2005年3月—2012年6月间58名患者在单中心接受解剖外内脏血管去分支化及随后的动脉瘤腔内隔绝术。内脏旁路的中位数为4支,最初的33例采用同期手术方式,而最近的25例采用分期手术。结果:患者中位年龄为69.0岁,50%为女性,所有患者存在严重合并症而不适合传统开放修复术。平均主动脉直径(6.7±1.2)cm,30 d/住院病死率、脑卒中率、永久性轻瘫/截瘫率分别为9%、0%以及4%。最近25例分期手术患者的这三种并发症率分别为4%、0%以及0%。平均随访时间(26±21)个月,内脏人工血管通畅率95.3%,所有闭塞的内脏人工血管均为肾动脉,无1例引起永久性截瘫,2例患者需再干预,1例出现Ib型内漏,1例出现III型内漏,5年免于再干预率为94%,Kaplan-Meier总体生存率为1年78%、5年62%,5年主动脉相关生存率为87%。结论:这些更新后的结果 ,继续支撑着这一观点:运用完全内脏动脉去分支联合动脉瘤腔内隔绝的杂交技术治疗高龄且不适合传统开放手术的高危TAAA患者是一种理想的选择,而采取分期手术的方式能取得更佳的结果。 | Gchad Hughes Nicholas D Andersen Jennifer M Hanna Richard L McCann 老启芳 | 2015 | 中国普通外科杂志2015，24，6： | 2 |
| 10 | Nationwide Volume and Mortality after Elective Surgery in Cirrhotic Patients显示文摘 | Nicholas G. Csikesz Louis N. Nguyen Jennifer F. Tseng Shimul A. Shah | 2008 | Journal of the American College of Surgeons2008，，1： | 2 |
| 11 | Pancreatic Fistula Following Pancreaticoduodenectomy: Clinical Predictors and Patient Outcomes显示文摘 | C. Max Schmidt Jennifer Choi Emilie S. Powell Constantin T. Yiannoutsos Nicholas J. Zyromski Attila Nakeeb Henry A. Pitt Eric A. Wiebke James A. Madura Keith D. Lillemoe William Jarnagin | 2009 | HPB Surgery2009，，： | 2 |
| 12 | Evidence for a functional hepatocyte growth factor receptor in human mesangial cells显示文摘 | Nicholas CK Angie NP Jennifer JC | 1988 | Regulatory Peptides1988，74，： | 1 |
| 13 | Cole Novel Approach of Medialization Thyroplasty with Arytenoid Adduction Performed under General Anesthesia with a Laryngeal Mask显示文摘 | Nicholas W Stow Jennifer W.Lee Ian E | | 0，，02： | 1 |
| 14 | 女篮运动员下肢损伤情况同赤脚与穿鞋状态下最大翻转力矩差别高度相关(英文)显示文摘背景:现有文献报告的女子篮球运动员受伤大多是踝关节扭伤,其损伤机制存在争议。目前尚无关于赤脚或穿鞋状态下肌肉不平衡及其与损伤严重程度之间关系的调查。本研究的目的是调查穿运动鞋对肌肉力量的作用以及与下肢损伤的关系,尤其针对女篮运动员,因为这一群体踝关节损伤高发。方法:11名大学女子篮球运动员在赛季前接受肌肉内翻及外翻力量测试,即在赤脚和穿鞋状态下,使用等速测力计进行测量。在不同条件下测量倒置与翻转的峰值扭矩、达到峰值的时间以及两种条件下从翻转到峰值的强度百分比。在赛季中记录她们的下肢损伤并按严重程度排名。用斯皮尔曼Rho相关系数(ρ)(a水平0.05)测定赤脚与穿鞋状态的峰值扭矩、达到峰值的时间以及强度百分比等级差别与损伤等级之间的关联。结果:受试者在120°/s状态下赤脚与穿鞋时内翻及外翻扭矩峰值的等级差别与其受伤程度等级相关。赛季中持续的运动员受伤程度等级与其赤脚和穿鞋时外翻扭矩峰值成强烈正相关(ρ=0.78,p=0.02)。结论赤脚与穿鞋状态下肌肉平衡差异大很可能导致运动员受伤;缩小赤脚与穿鞋状态下翻转力矩的差异能减小受伤倾向。今后的研究应关注赤脚与穿鞋状态下恢复肌肉力量的效果。 | Jennifer M.Yentes Max J.Kurz Nicholas Stergiou | 2014 | Journal of Sport and Health Science2014，3，3： | 1 |
| 15 | Detection of Occult Metastasis in Lymph Nodes From Colorectal Cancer Patients: A Multiple-Marker Reverse Transcriptase-Polymerase Chain Reaction Study显示文摘 | Gong Chen M.D M.S. Cassandra M. McIver B.Sc. M. Texler M.D. Julia M. Lloyd Ph.D. Nicholas Rieger F.R.A.C.S. Peter J. Hewett F.R.A.C.S. De sen Wan M.D. Jennifer E. Hardingham Ph.D | 2004 | Diseases of the Colon & Rectum2004，，5： | 1 |
| 16 | Analysis of Glucose Responses to Automated Insulin Suspension With Sensor-Augmented Pump Therapy显示文摘 | Trang T. Ly Jennifer A. Nicholas Adam Retterath Elizabeth A. Davis Timothy W. Jones | 2012 | Diabetes Care2012，，7： | 1 |
| 17 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 18 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 19 | Detection of respiratory viruses and bacteria in children using a twenty-two target reverse-transcription real-time PCR(RT-qPCR)panel显示文摘Background:Rapid detection of the wide range of viruses and bacteria that cause respiratory infection in children is important for patient care and antibiotic stewardship.We therefore designed and evaluated a readyto-use 22 target respiratory infection reverse-transcription real-time polymerase chain reaction(RT-qPCR)panel to determine if this would improve detection of these agents at our pediatric hospital.Methods:RT-qPCR assays for twenty-two target organisms were dried-down in individual wells of 96 well plates and saved at room temperature.Targets included 18 respiratory viruses and 4 bacteria.After automated nucleic acid extraction of nasopharyngeal aspirate(NPA)samples,rapid qPCR was performed.RT-qPCR results were compared with those obtained by the testing methods used at our hospital laboratories.Results:One hundred fi fty-nine pediatric NPA samples were tested with the RT-qPCR panel.One or more respiratory pathogens were detected in 132/159(83%)samples.This was significantly higher than the detection rate of standard methods(94/159,59%)(P<0.001).This difference was mainly due to improved RT-qPCR detection of rhinoviruses,parainfl uenza viruses,bocavirus,and coronaviruses.The panel internal control assay performance remained stable at room temperature storage over a two-month testing period.Conclusions:The RT-qPCR panel was able to identify pathogens in a high proportion of respiratory samples.The panel detected more positive specimens than the methods in use at our hospital.The pre-made panel format was easy to use and rapid,with results available in approximately 90 minutes.We now plan to determine if use of this panel improves patient care and antibiotic stewardship. | Chelsey Ellis Amita Misir Charles Hui Mona Jabbour Nicholas Barrowman JonathanLangill Jennifer Bowes Robert Slinger | 2016 | World Journal of Pediatrics2016，12，2： | 1 |
| 20 | Childhood obesity and proximity to urban parks and recreational resources: A longitudinal cohort study显示文摘 | Jennifer Wolch Michael Jerrett Kim Reynolds Rob McConnell Roger Chang Nicholas Dahmann Kirby Brady Frank Gilliland Jason G. Su Kiros Berhane | 2010 | Health and Place2010，，1： | 1 |
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