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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | The calcium sensing receptor: from calcium sensing to signaling显示文摘The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic hypercalciuria.Compelling evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological processes.In this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated mutations.This systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling. | ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 3 | Smart Cities as Cyber-Physical Social Systems显示文摘新兴智慧城市是城市环境的新一代创新服务,包括交通、能源分布、医疗、环境监测、商务、商业、紧急响应和社会活动。要想实现这种为城市场景服务的各项技术,需要将智慧城市视为一个整体的信息物理融合系统(CPS),这其中包括新的移动软件平台和对治安、安全、隐私和大量信息处理的严格要求。本文旨在确定智慧城市的关键特征,进而讨论了一些由CPS观点出发而得出的经验教训,并概述了一些空白领域的基础研究内容。 | Christos G. Cassandras | 2016 | Engineering2016，2，2： | 13 |
| 4 | Impact of obesity treatment on gastroesophageal refluxdisease显示文摘Gastroesophageal reflux disease(GERD) is a frequently encountered disorder. Obesity is an important risk factor for GERD, and there are several pathophysiologic mechanisms linking the two conditions. For obese patients with GERD, much of the treatment effort is focused on weight loss and its consistent benefit to symptoms, while there is a relative lack of evidence regarding outcomes after novel or even standard medical therapy is offered to this population. Physicians are hesitant to recommend operative anti-reflux therapy to obese patients due to the potentially higher risks and decreased efficacy, and these patients instead are often considered for bariatric surgery. Bariatric surgical approaches are broadening, and each technique has emerging evidence regarding its effect on both the risk and outcome of GERD. Furthermore, combined antireflux and bariatric options are now being offered to obese patients with GERD. However, currently Rouxen-Y gastric bypass remains the most effective surgical treatment option in this population, due to its consistent benefits in both weight loss and GERD itself. This article aims to review the impact of both conservative and aggressive approaches of obesity treatment on GERD. | Abraham Khan Aram Kim Cassandra Sanossian Fritz Francois | 2016 | World Journal of Gastroenterology2016，22，4： | 9 |
| 5 | Strigolactones and the Regulation of Pea Symbioses in Response to Nitrate and Phosphate Deficiency显示文摘为植物荷尔蒙的最近识别的组的新角色, strigolactones,当前在活跃调查下面。他们的关键角色之一是调整植物 symbioses。这些混合物在荚在 arbuscular mycorrhizal symbioses 并且作为生节的一个积极管理者充当一个根围信号。磷并且土壤的氮地位作为 strigolactone 的一个强大的管理者出现了生产。直到现在,然而,在响应滋养的缺乏调整 mycorrhizal 开发和生节的 strigolactones 的潜在的角色没被证明。在这份报纸,在调整这些 symbioses 的 strigolactone 合成和反应的角色在豌豆(Pisum sativum L.) 被检验。豌豆很好被适合到这研究,自从有在荚之中是唯一的描绘得好的 strigolactone 生合成和反应异种的一个范围。证据在 mycorrhizal 开发期间在根以内为 strigolactone 反应被为一个新奇内长的角色提供,除了真菌的搭挡上的 strigolactones 的行动。调整 mycorrhizal 开发的 strigolactone 反应小径也看起来与调整生节的反应小径有点不同。最后,有 strigolactone 缺乏的豌豆异种的研究显示尽管有由氮和磷酸盐的 strigolactone 生产的强壮的规定, strigolactones 没被要求响应滋养的缺乏调整这些 symbioses。 | Eloise Foot Kaori Yoneyama Cassandra J. Hugill Laura J. Quittenden James B. Reidt | 2013 | Molecular Plant2013，6，1： | 8 |
| 6 | A comparison of three methods of decellularization of pig corneas to reduce immunogenicity显示文摘·AIM: To investigate whether decellularization using different techniques can reduce immunogenicity of the cornea, and to explore the decellularized cornea as a scaffold for cultured corneal endothelial cells(CECs).Transplantation of decellularized porcine corneas increases graft transparency and survival for longer periods compared with fresh grafts.·METHODS: Six-month-old wild-type pig corneas were cut into 100-200 μm thickness, and then decellularized by three different methods: 1) 0.1% sodium dodecyl sulfate(SDS); 2) hypoxic nitrogen(N2); and 3) hypertonic NaCl. Thickness and transparency were assessed visually. Fresh and decellularized corneas were stained with hematoxylin/eosin(H&E), and for the presence of galactose-α1,3-galactose(Gal) and N-glycolylneuraminic acid(NeuGc, a nonGal antigen). Also, a human IgM/IgG binding assay was performed. Cultured porcine CECs were seeded on the surface of the decellularized cornea and examined after H&E staining.· RESULTS: All three methods of decellularization reduced the number of keratocytes in the stromal tissue by >80% while the collagen structure remained preserved. No remaining nuclei stained positive for Gal or NeuGc, and expression of these oligosaccharides on collagen was also greatly decreased compared to expression on fresh corneas. Human IgM/IgG binding to decellularized corneal tissue was considerably reduced compared to fresh corneal tissue. The cultured CECs formed a confluent monolayer on the surface of decellularized tissue.· CONCLUSION: Though incomplete, the significant reduction in the cellular component of the decellularized cornea should be associated with a significantly reduced in vivo immune response compared to fresh corneas. | Whayoung Lee Yuko Miyagawa Cassandra Long David K.C.Cooper Hidetaka Hara | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 7 |
| 7 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 8 | Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy显示文摘Dysregulated Wnt signaling is associated with the pathogenesis of cancers, fibrosis, and vascular diseases. Inhibition of Wnt signaling has shown efficacy in various pre-clinical models of these disorders. One of the key challenges in developing targeted anti-cancer drugs is to balance efficacy with on-target toxicity. Given the crucial role Wnts play in the differentiation of osteoblasts and osteoclasts, acute inhibition of Wnt signaling is likely to affect bone homeostasis. In this study, we evaluated the skeletal effect of small molecule inhibitor of an o-acyl transferase porcupine(PORCN) that prevents Wnt signaling by blocking the secretion of all Wnts. Micro-computed tomography and histomorphometric evaluation revealed that the bones of mice treated with two structurally distinct PORCN inhibitors LGK974 and ETC-1922159(ETC-159) had loss-of-bone volume and density within 4 weeks of exposure. This decreased bone mass was associated with a significant increase in adipocytes within the bone marrow. Notably,simultaneous administration of a clinically approved anti-resorptive, alendronate, a member of the bisphosphonate family,mitigated loss-of-bone mass seen upon ETC-159 treatment by regulating activity of osteoclasts and blocking accumulation of bone marrow adipocytes. Our results support the addition of bone protective agents when treating patients with PORCN inhibitors.Mitigation of bone toxicity can extend the therapeutic utility of Wnt pathway inhibitors. | Babita Madan Mitchell J.McDonald Gabrielle E.Foxa Cassandra R.Diegel Bart O.Williams David M.Virshup | 2018 | Bone Research2018，6，2： | 2 |
| 9 | Preliminary results of antiscarring therapy in the prevention of postendoscopic esophageal mucosectomy strictures显示文摘 | Yuhsin Wu Steve J. Schomisch Cassandra Cipriano Amitabh Chak Richard H. Lash Jeffrey L. Ponsky Jeffrey M. Marks | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 10 | 骨髓增生异常综合征表皮生长因子受体的表达及其与细胞凋亡的关系显示文摘目的 探索骨髓增生异常综合征 (MDS)造血细胞中表皮生长因子受体 (EGFR)表达及其与细胞凋亡的关系。方法 取 18例MDS患者骨髓有核细胞经离心涂片机制片 ,用免疫酶标记方法(碱性磷酸酶 抗碱性磷酸酶系统 ,APAAP)及TdT介导的dUTP缺口末端 (荧光素 )标记 (TUNEL)法先后在同一标本上检测EGFR表达和凋亡信号。 9名正常人骨髓作对照。另外 ,18例MDS中有 15例、9名正常人中有 6名经流式细胞仪分选CD3 4+细胞并制备涂片后按上述方法进行EGFR和凋亡检测 ,并分析两者间的关系。结果 ①MDS骨髓细胞EGFR表达 [(38.6± 2 4.6 ) %]高于正常对照 [(18.1±14 0 ) %](P <0 .0 5 ) ;②MDS细胞凋亡主要发生在EGFR阴性细胞 (16 .1%) ,EGFR阳性细胞中凋亡细胞仅占 1.4%(P <0 .0 1) ,EGFR表达与细胞凋亡呈负相关 (r =- 0 .70 1;tr=3.6 0 ;P <0 .0 1) ;③CD3 4+细胞EGFR表达阳性率RAEB RAEB t CMML组高于RA RAS组 ,分别为 (2 0 .6± 2 7.9) %和 (8.9±11 8) %,但差异无显著性 ,细胞凋亡率RAEB RAEB t CMML组低于RA RAS组 ,分别为 (18.2± 12 5 ) %和 (4 5 .2± 2 0 .5 ) %(P <0 .0 5 )。结论 MDS造血细胞过度表达EGFR。EGFR表达增高可能预示MDS的恶性增殖倾向并通过某种途径抑制细胞凋亡。 | 李晓 浦权 Cassandra Beckham Joachim H.Deeg | 2003 | 中华血液学杂志2003，24，1： | 2 |
| 11 | Team-based stepped care in integrated delivery settings显示文摘Fragmented health care delivery is recognized as increasingly problematic.Integrated care has been advanced as a reform that will improve quality of care and lower costs.Despite the application of integrated care systems in the United States,there has been a limited amount of empirical work explicating the most effective health care pathways.Stepped care has been proposed as a framework by which to implement coordinated team-based care and has gained preliminary empirical support.In this manuscript a rationale for team-based stepped care is presented,tools for implementation are provided,and future research directions are suggested. | Cassandra Snipes Alexandros Maragakis William O’Donohue | 2015 | Family Medicine and Community Health2015，3，1： | 2 |
| 12 | Nitrogen-linked diphosphine ligands with ethers attached to nitrogen for chromium-catalyzed ethylene ti- and tetramerizations显示文摘 | Paul R E Cassandra M Pringle P G | 2006 | Organometallics2006，25，22： | 1 |
| 13 | 对谈:乡建与建筑学显示文摘'中国的建筑设计行业受专业分工体制影响,各专业、各阶段相对独立,各自为政,缺乏综合性。在乡村里,由于资源限制,行业分工不明显,适用于城市的规范也不能覆盖乡村,因此,乡村建设具有很强的综合性,乡村实践对我们的建筑学是一个很好的补充,在教育中也能让学生掌握更加全面的知识。' | 宋玮 王维仁 周凌 何崴 王磊 孟凡浩 王求安 佟阳 Cassandra Osterman | 2019 | 建筑实践2019，2，8： | 1 |
| 14 | Peak discharge of a Pleistocene lava-dam outburst floods in Grand Canyon,Arizona,USA显示文摘 | CASSANDRA R F ROBERT H W THURE E C | 2006 | Quaternary Research2006，，7： | 1 |
| 15 | Production of secretory and extracellular N-linked glycoproteins in Escherichia coli显示文摘 | Adam CF Charles HH Cassandra G | | 0，，03： | 1 |
| 16 | Interrelationship of soil moisture and temperature to sylvatic plague cycle among prairie dogs in the Western United States显示文摘Plague,caused by Yersinia pestis,is a flea-borne disease that is endemic in areas throughout the world due to its successful maintenance in a sylvatic cycle,mainly in areas with temperate climates.Burrowing rodents are thought to play a key role in the enzootic maintenance as well as epizootic outbreaks of plague.In the United States,prairie dogs(Cynomys),rodents(Muridae),and ground squirrels(Spermophilus)are susceptible to infection and are parasitized by fleas that transmit plague.In particular,prairie dogs can experience outbreaks that rapidly spread,which can lead to extirpation of colonies.A number of ecological parameters,including climate,are associated with these epizootics.In this study,we asked whether soil parameters,primarily moisture and temperature,are associated with outbreaks of plague in black-tailed prairie dogs and Gunnison’s prairie dogs in the Western United States,and at what depth these associations were apparent.We collected publicly available county-level information on the occurrence of population declines or colony extirpation,while historical soil data was collected from SCAN and USCRN stations in counties and states where prairie dogs have been located.The analysis suggests that soil moisture at lower depths correlates with colony die-offs,in addition to temperature near the surface,with key differences within the landscape ecology that impact the occurrence of plague.Overall,the model suggests that the burrow environment may play a significant role in the epizootic spread of disease amongst black-tailed and Gunnison’s prairie dogs. | Cassandra D.PAULING Deborah L.FINKE Deborah M.ANDERSON | 2021 | Integrative Zoology2021，16，6： | 1 |
| 17 | Marine ecosystem approaches to management: challenges and lessons in the United States显示文摘 | Cassandra Barnes | 2008 | Marine Policy2008，，32： | 1 |
| 18 | A sample path approach for solving the ground-holding policy problem in air traffic control显示文摘 | PANAYIOTOU C G CASSANDRAS C G | 2001 | IEEE Transactions on Control SystemsTechnology2001，9，3： | 1 |
| 19 | A instability of adenoviral vectors during transport 显示文摘 | CASSANDRA N H ESTUARDO A C | 1999 | Nat Med1999，8，5： | 1 |
| 20 | Value-Creating Ecologies:Understanding Next Generation Business Systems显示文摘 | Hearn Grey Cassandra Pace | | 0，，： | 1 |
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